Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4′-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells

Autor: Yen-Po Cheng, Shiming Li, Wan-Ling Chuang, Chia-Hsuan Li, Guan-Jun Chen, Ching-Chin Chang, Chi-Hung R. Or, Ping-Yi Lin, Chia-Che Chang

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 13, p 3366 (2019)

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis, largely due to resistance to current radiotherapy and Temozolomide chemotherapy. The constitutive activation of Signal Transducer and Activator of Transcrip

Externí odkaz: https://doaj.org/article/b14a28e04aef49e9bbd3aee8a6beea5a

Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

Autor: Yi-Ju Chen, Ching-Chin Chang, Chi-Hung R Or, You-Chen Lai, Chia-Che Chang, Chiao-Wen Huang

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1773 (2020)

Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of antiapoptotic BCL-2 family proteins is closely linked to neoplastic progression and chemoresistance. Obatoclax is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de460bfb375eaed4d57499d92bfcb05
http://europepmc.org/articles/PMC7084590

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Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo

Autor: Chi-Hung R. Or, Cheesang Ho, Hong-Lin Su, Wee-Chyan Lee, Shu-Yi Yang, Chia-Che Chang

Publikováno v: Oncology Reports. 36:3465-3471

Melanoma is the most aggressive skin malignancy with a high rate of mortality and is frequently refractory to many therapeutics, thus demanding the discovery of novel effective anti-melanoma agents. Diphenhydramine (DPH) is an H1 histamine receptor a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95533a2f5ef4d9d44509207fda1dc88a
https://doi.org/10.3892/or.2016.5201

Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells

Autor: Cheesang Ho, Yachu Chang, Wei-Cheng Lin, Chang-Po Huang, Muk-Wing Cheung, Wee-Chyan Lee, Chi-Hung R. Or, Chia-Che Chang, Hong-Lin Su

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 1, p 44 (2016)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 44

Colorectal cancer is the third most common cancer worldwide. Aberrant overexpression of antiapoptotic BCL-2 (B-cell lymphoma 2) family proteins is closely linked to tumorigenesis and poor prognosis in colorectal cancer. Obatoclax is an inhibitor targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865a098cd21ca96187d97b09dabbd9b2
http://www.mdpi.com/1422-0067/18/1/44