Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chi-Hsin R. King"'
Autor:
Ismail Mitha, Andrè J. Bester, Ming-Chu Hsu, Ren-Guang Wu, Dirkie Johanna Van Rensburg, Reury-Perng Perng, Ming-Lin Ho, Joseph Kasumba, Yu-Ting Chang, Chi-Hsin R. King, David T. Chung, Li-Wen Chang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:4098-4106
Nemonoxacin, a novel nonfluorinated quinolone, exhibits potent in vitro and in vivo activities against community-acquired pneumonia (CAP) pathogens, including multidrug-resistant Streptococcus pneumoniae . Patients with mild to moderate CAP ( n = 265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046871d323e7fa47702e9a68982badcb
https://doi.org/10.1128/aac.00295-10
https://doi.org/10.1128/aac.00295-10
Autor:
Karen L. Huss, Charles R. Heap, William T. McMillen, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer, Robert M. Campbell, Matthew D. Voss, Bryan D. Anderson, Chi Hsin R. King, Elizabeth A. Dierks, Hong Yu Li, Wang Yan, Lei Yan, Sreenivasa Reedy Mundla, Karen S. Britt, Denis J. McCann
Publikováno v:
Journal of Medicinal Chemistry. 51:2302-2306
In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74284fcfb2d481b7bc2d3fa3c78f84f8
https://doi.org/10.1021/jm701199p
https://doi.org/10.1021/jm701199p
Publikováno v:
Synthesis. 2006:2743-2747
An efficient synthesis of the side-chain precursor crucial to the preparation of 18-methoxycoronaridine (18-MC) has been developed. This procedure represents an improvement upon the original synthesis, in which regioisomers were separated by chromato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4874672dad5d7c0eabb8ab9a94698a
https://doi.org/10.1055/s-2006-942489
https://doi.org/10.1055/s-2006-942489
Autor:
Charles R. Heap, Jill R. Wagner, Lei Yan, Sreenivasa Reedy Mundla, Wang Yan, William T. McMillen, Ku X. Lu, David K. Clawson, Bryan D. Anderson, Chi Hsin R. King, Hong Yu Li, Karen S. Britt, Robert M. Campbell, Jonathan M. Yingling, Matthew Ernst Voss
Publikováno v:
Journal of Medicinal Chemistry. 49:2138-2142
Novel dihydropyrrolopyrazole-substituted benzimidazoles were synthesized and evaluated in vitro as inhibitors of transforming growth factor-beta type I receptor (TGF-beta RI), TGF-beta RII, and mixed lineage kinase-7 (MLK-7). These compounds were fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5274b1d7d4f5ea6265cabe5cd42aed8
https://doi.org/10.1021/jm058209g
https://doi.org/10.1021/jm058209g
Autor:
Brian T. Gregg, Zinovy Itov, Mark A Helle, Harold Meckler, Joyce C. Knutson, Mary E. Mateo, William B. Geiss, Lisa D. Coutts, Mark W. Zettler, Chi-Hsin R. King
Publikováno v:
Organic Process Research & Development. 6:246-255
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), wh...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16f7c550721591c31a7e8dd9c2db36b
https://doi.org/10.1021/op010229e
https://doi.org/10.1021/op010229e
Autor:
Isabelle M. Maisonneuve, R. Jason Herr, Harold Meckler, Chi-Hsin R. King, Stanley D. Glick, Michael P. Trova
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:473-476
Chemical resolution of racemic 18-methoxycoronaridine (18-MC) was achieved by the formation of its diastereomeric sulfonamides with either (R)-(-)- or (S)-(+)-camphorsulfonyl chloride. Preliminary assessment of (+)-, (-)-, and (+/-)-18-MC x HCl showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9619e541074ccb96696bef8d61ff3a11
https://doi.org/10.1016/s0960-894x(00)00033-0
https://doi.org/10.1016/s0960-894x(00)00033-0
Publikováno v:
Synthetic Communications. 26:2213-2221
A convenient route to previously unknown 8-acylated castanospermines is illustrated by synthesis of the butyryl derivative.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bc97dba3e853d8de89a5e0d8cc98cd6
https://doi.org/10.1080/00397919608003581
https://doi.org/10.1080/00397919608003581
Autor:
Chi-Hsin R. King, Alexey L. Margolin
Publikováno v:
Tetrahedron: Asymmetry. 4:943-946
A new technique - immobilzation of substrates on solid supports - was applied to the synthesis of a new potent optically pure serotonin receptor antagonist.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6173d29b726b567d5dc9c4b54cb107d
https://doi.org/10.1016/s0957-4166(00)80136-6
https://doi.org/10.1016/s0957-4166(00)80136-6
Publikováno v:
ChemInform. 27
A convenient route to previously unknown 8-acylated castanospermines is illustrated by synthesis of the butyryl derivative.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68597f4059753b068ddab242c59cd34
https://doi.org/10.1002/chin.199636222
https://doi.org/10.1002/chin.199636222
Autor:
Chi-Hsin R. King, Philip M. Weintraub
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7299cf3eb03433005c60fa849a739394
https://doi.org/10.1002/chin.199727202
https://doi.org/10.1002/chin.199727202