Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Chi-Chung Hui"'
Autor:
Yena Oh, Rimshah Abid, Saif Dababneh, Marwan Bakr, Termeh Aslani, David P. Cook, Barbara C. Vanderhyden, Jin G. Park, Nikhil V. Munshi, Chi-Chung Hui, Kyoung-Han Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that coordinates electrical impulse generation and propagation for synchronized heart contractions. Although the components of the CCS, including the sinoatrial n
Externí odkaz:
https://doaj.org/article/5d388a81cb15435ab16ec526c8ef54d5
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114083- (2024)
Summary: A common cause of deafness in humans is dysregulation of the endocochlear potential generated by the stria vascularis (SV). Thus, proper formation of the SV is critical for hearing. Using single-cell transcriptomics and a series of Shh signa
Externí odkaz:
https://doaj.org/article/fca347d36255492486cb4ad2eee8a044
Autor:
Zhixin Li, Kathy Nga-Chu Lui, Sin-Ting Lau, Frank Pui-Ling Lai, Peng Li, Patrick Ho-Yu Chung, Kenneth Kak-Yuen Wong, Paul Kwong-Hing Tam, Maria-Mercedes Garica-Barcelo, Chi-Chung Hui, Pak Chung Sham, Elly Sau-Wai Ngan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells, leading to intestinal obstruction. Here, using induced pluripotent stem cell-based models of Hirschsprung and single
Externí odkaz:
https://doaj.org/article/900f75b8630e4433832db65c3d9cbb22
Autor:
Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular conv
Externí odkaz:
https://doaj.org/article/091429a4162845e7a18371f487596c6f
Autor:
Ji-Eun Kim, Lijiang Fei, Wen-Chi Yin, Sabrina Coquenlorge, Abilasha Rao-Bhatia, Xiaoyun Zhang, Sammy Shun Wai Shi, Ju Hee Lee, Noah A. Hahn, Wasi Rizvi, Kyoung-Han Kim, Hoon-Ki Sung, Chi-chung Hui, Guoji Guo, Tae-Hee Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates W
Externí odkaz:
https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b58
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The hypothalamus is a brain region that exhibits highly conserved anatomy across vertebrate species and functions as a central regulatory hub for many physiological processes such as energy homeostasis and circadian rhythm. Neurons in the arcuate nuc
Externí odkaz:
https://doaj.org/article/18997d16be36485e8ca6d92e85cf436a
Autor:
Theodora Yung, Frankie Poon, Minggao Liang, Sabrina Coquenlorge, Emily C. McGaugh, Chi-chung Hui, Michael D. Wilson, M. Cristina Nostro, Tae-Hee Kim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Dynamic mesenchyme derived signals are known to direct proper organ formation and cell specification in vivo. Here the authors show in mice that mesenchyme derived Hedgehog and Wnt instruct the formation of the pancreas and beta cells, and that Wnt i
Externí odkaz:
https://doaj.org/article/ea06aadd0d02439fa9d516f607e823db
Autor:
Min Jeong Kim, Daniella Febbraro, Sofia Farkona, Taylor Gillmore, Joe Eun Son, Romario Regeenes, Huntley H. Chang, Evan Pollock-Tahiri, Jiaqi Yang, Yoo Jin Park, Tharini Sivasubramaniyam, Soo Jung Oh, Punit Saraon, Igor Stagljar, Jonathan V. Rocheleau, Chi-Chung Hui, Isabella Caniggia, Zhenyu Hao, Tak W. Mak, Ana Konvalinka, Minna Woo
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101185- (2021)
Objective: Autophagy is a physiological self-eating process that can promote cell survival or activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining muscle mass and function that is critical to sustain mobility a
Externí odkaz:
https://doaj.org/article/3ad65f38e4f146d3afd318e6c0762d84
Autor:
Ke Zhang, Fang Yu, Jian Zhu, Sue Han, Jiehui Chen, Xuanyuan Wu, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He, Naihe Jing, Ke Tang
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, the genetic basis and underlying mechanisms remain u
Externí odkaz:
https://doaj.org/article/a4429567bc564f6c9b55521ae9a3cf26
Autor:
Sabrina Coquenlorge, Wen-Chi Yin, Theodora Yung, Jingyi Pan, Xiaoyun Zhang, Rong Mo, Jaques Belik, Chi-chung Hui, Tae-Hee Kim
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 3006-3018.e4 (2019)
Summary: Gut mesenchyme provides key stem cell niche signals such as Wnt ligands, but how these signals are regulated is unclear. Because Hedgehog (Hh) signaling is critical for gut mesenchymal development and tumorigenesis, we investigated Hh-mediat
Externí odkaz:
https://doaj.org/article/73f4707fa8914c5c9526064c485f5755