Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Chi-Ching Hwang"'
Autor:
Chien-Hui Huang, Sin-Yu Hou, Scott Severance, Chi-Ching Hwang, Bo-Kai Fang, Ming-Mao Gong, Siao-Lei Yu, Yung-Chieh Weng, Li-Fang Wang, Chia-Yen Dai, Su-Hung Wang, Hsing-Tao Kuo, Jeh-Jeng Wang, Tzu-Pin Wang
Publikováno v:
ACS Omega, Vol 8, Iss 48, Pp 46073-46090 (2023)
Externí odkaz:
https://doaj.org/article/6ccadc8be69642fb9275f14f9633fd59
Autor:
Chien-Hui Huang, Yi-Ting Chang, Scott Severance, Jui-Ying Feng, Sin-Yu Hou, Ming-Mao Gong, Chi-Ching Hwang, Chia‐Yen Dai, Jeh-Jeng Wang, Tzu-Pin Wang
Publikováno v:
Practical Laboratory Medicine, Vol 31, Iss , Pp e00298- (2022)
Objectives: Butyrylcholinesterase (BChE) is an important biomarker in serum, and aberrant BChE activity indicates onset and progression of human diseases. The duration of serum storage at −80 °C may introduce variability into and compromise the re
Externí odkaz:
https://doaj.org/article/a8e1d0362ac0444f975bea7b0040977b
Publikováno v:
Catalysts, Vol 12, Iss 10, p 1094 (2022)
Enzymes are powerful biological catalysts for natural substrates but they have low catalytic efficiency for non-natural substrates. Protein engineering can be used to optimize enzymes for catalysis and stability. 3α-Hydroxysteroid dehydrogenase/carb
Externí odkaz:
https://doaj.org/article/6f1be6357a8248abad432cb20d13c961
Autor:
Bo-Kai Fang, Chia-Yen Dai, Scott Severance, Chi-Ching Hwang, Chien-Hui Huang, Sin-Yu Hou, Bao-Lin Yeh, Ming-Mao Gong, Yun-Hao Chou, Jeh-Jeng Wang, Tzu-Pin Wang
Publikováno v:
Molecules, Vol 27, Iss 8, p 2435 (2022)
The lactonase activity of paraoxonase 1 (PON1) has a crucial antiatherogenic function, and also serves as an important biochemical marker in human blood because the aberrant lactonase activity of PON1 is a key indicator for a number of diverse human
Externí odkaz:
https://doaj.org/article/1ae83f6a865046f2a340ca6329619609
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6330 (2021)
Beta2-microglobulin (B2M) a key component of major histocompatibility complex class I molecules, which aid cytotoxic T-lymphocyte (CTL) immune response. However, the majority of studies of B2M have focused only on amyloid fibrils in pathogenesis to t
Externí odkaz:
https://doaj.org/article/11545c20a98549dca313ff7f24143f52
Autor:
Ming-Mao Gong, Chia-Yen Dai, Scott Severance, Chi-Ching Hwang, Bo-Kai Fang, Heng-Bo Lin, Chien-Hui Huang, Chi-Wi Ong, Jeh-Jeng Wang, Pei-Lun Lee, Tzu-Pin Wang
Publikováno v:
Catalysts, Vol 10, Iss 10, p 1169 (2020)
Butyrylcholinesterase (BChE) is a biomarker in human blood. Aberrant BChE activity has been associated with human diseases. Here we developed a fluorescence resonance energy transfer (FRET) chemical probe to specifically quantify BChE activity in ser
Externí odkaz:
https://doaj.org/article/1695540961034863b5785cef0f4ce64c
Autor:
Chi-Ching Hwang, Yi-Hsun Chang, Hwei-Jen Lee, Tzu-Pin Wang, Yu-Mei Su, Hsin-Wei Chen, Po-Huang Liang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63594 (2013)
3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni reversibly catalyzes the oxidation of androsterone with NAD(+) to form androstanedione and NADH. Structurally the substrate-binding loop of the residues, T188-K208, is un
Externí odkaz:
https://doaj.org/article/5d21877c0bad475fb497996253eccd6d
Autor:
Hwei-Jen Lee, Yung-Lung Chang, Jen-Tzu Liu, Sheng-Peng Wu, Wei-Min Huang, Chi-Ching Hwang, Chih-Wei Huang, Kai-Ling Huang
Publikováno v:
Biochemical Journal. 478:2201-2215
4-Hydroxylphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxylphenylpyruvate (HPP) to homogentisate, the important step for tyrosine catabolism. Comparison of the structure of human HPPD with the substrate-bound structure of A. th
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6330, p 6330 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Beta2-microglobulin (B2M) a key component of major histocompatibility complex class I molecules, which aid cytotoxic T-lymphocyte (CTL) immune response. However, the majority of studies of B2M have focused only on amyloid fibrils in pathogenesis to t
Publikováno v:
Chemico-Biological Interactions. 302:183-189
The binding energy of enzyme and substrate is used to lower the activation energy for the catalytic reaction. 3α-HSD/CR uses remote binding interactions to accelerate the reaction of androsterone with NAD+. Here, we examine the enthalpic and entropi