ENHANCING ADULT NEUROGENESIS RESCUES HIPPOCAMPAL COGNITIVE FUNCTIONS IN AN ALZHEIMER’S MOUSE MODEL

Autor: Chi-Chieh Lee, Brett Emery, Shahrukh Khanzada, Xin Hu, Hayder Amin, Federico Calegari

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S438- (2023)

Externí odkaz: https://doaj.org/article/9f4963360c594be3a1901864db25ca95

The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair

Autor: Tzu-Wei Chuang, Chia-Chen Lu, Chun-Hao Su, Pei-Yu Wu, Sarasvathi Easwvaran, Chi-Chieh Lee, Hung-Che Kuo, Kuan-Yang Hung, Kuo-Ming Lee, Ching-Yen Tsai, Woan-Yuh Tarn

Publikováno v: iScience, Vol 13, Iss , Pp 402-415 (2019)

Summary: DNA repair deficiency leads to genome instability and hence human disease. Depletion of the RNA processing factor Y14/RBM8A in cultured cells or Rbm8a haplodeficiency in the developing mouse cortex results in the accumulation of DNA damage.

Externí odkaz: https://doaj.org/article/941a99c5daad474c96dcd5cc3f13d6ef

Role of Cisd2 in Nutrient Stress and starvation Response of Mice

Autor: Chi-Chieh Lee, 李紀潔

103
CDGSH iron-sulfur domain-containing protein 2 (Cisd2, synonyms: nutrition-deprivation autophagy factor-1) is a highly conserved gene from fly to human and locates on mitochondria outermembrane. Deficiency of Cisd2 causes premature aging and

Externí odkaz: http://ndltd.ncl.edu.tw/handle/fncwu4

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

Autor: Gonzalo Arias-Gil, Gerd Kempermann, Benedetta Artegiani, Joanna M. Wasielewska, Gabriel Berdugo-Vega, Chi-Chieh Lee, Federico Calegari, Kentaroh Takagaki, Michael T. Lippert, Adrian López-Fernández

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 11(1):135
Nature Communications 11(1), 135 (2020). doi:10.1038/s41467-019-14026-z

Functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f8c45704bcf362ba69e3a7a7ea41de
https://doaj.org/article/053faa42850e4fdca82723e9f3346693

Adult-born neurons promote cognitive flexibility by improving memory precision and indexing

Autor: Federico Calegari, Gerd Kempermann, Alexander Garthe, Gabriel Berdugo-Vega, Chi-Chieh Lee

Publikováno v: Hippocampus 31(10), 1068-1079 (2021). doi:10.1002/hipo.23373

Adult neurogenesis in the hippocampal dentate gyrus (DG) is an extraordinary form of plasticity fundamental for cognitive flexibility. Recent evidence showed that newborn neurons differentially modulate input to the infra- and supra-pyramidal blades

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c327f34fb141ff4112c7f0d77d2b58
https://pubmed.ncbi.nlm.nih.gov/34174010