Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Chi V. Dang"'
Autor:
Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang, Hongguang Shao, Harsh Dweep, Yao-Yu Gong, Rebekah Brooks, Patricia Brafford, Adam J. Wolpaw, Yool Lee, Ashani Weeraratna, Amita Sehgal, Meenhard Herlyn, Andrew Kossenkov, David Speicher, Peter K. Sorger, Sandro Santagata, Chi V. Dang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells
Externí odkaz:
https://doaj.org/article/c859ff64da1345c9ad8da5b07e20c424
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Autor:
Annie L. Hsieh, Xiangzhong Zheng, Zhifeng Yue, Zachary E. Stine, Anthony Mancuso, Seth D. Rhoades, Rebekah Brooks, Aalim M. Weljie, Robert N. Eisenman, Amita Sehgal, Chi V. Dang
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1778-1788.e4 (2019)
Summary: Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the molecular clock in cancer cells. Here, we demonstrate that misregulation of dMyc
Externí odkaz:
https://doaj.org/article/3ea8bfb9495d43c99059d82693f0ca54
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/074d71d5036b4a18bd4da6fc68944acc
Autor:
Yao-Yu Gong, Hongguang Shao, Yu Li, Patricia Brafford, Zachary E. Stine, Jing Sun, Dean W. Felsher, Jordan S. Orange, Steven M. Albelda, Chi V. Dang
Publikováno v:
Cancer Research Communications. 2:842-856
Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity inhibits T an
Autor:
Chi V. Dang, Steven M. Albelda, Jordan S. Orange, Dean W. Felsher, Jing Sun, Zachary E. Stine, Patricia Brafford, Yu Li, Hongguang Shao, Yao-Yu Gong
Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity inhibits T an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e27d2c7f5cb21c8973d7669cdf6618
https://doi.org/10.1158/2767-9764.c.6550796.v1
https://doi.org/10.1158/2767-9764.c.6550796.v1
Autor:
Chi V. Dang, Steven M. Albelda, Jordan S. Orange, Dean W. Felsher, Jing Sun, Zachary E. Stine, Patricia Brafford, Yu Li, Hongguang Shao, Yao-Yu Gong
Supplementary Fig. S1. CA9 fails to enhance the cytolytic activity of NK-92 cells in vitro. Supplementary Fig. S2. NHE1 enhances in vitro cytotoxicity of NK-92 cells without affecting proliferation or survival. Supplementary Fig. S3. Representative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6886fb7909f59be4264cf41eea89ab6c
https://doi.org/10.1158/2767-9764.22544936.v1
https://doi.org/10.1158/2767-9764.22544936.v1
Autor:
Chi V. Dang, Lin Zhang, Anil K. Sood, Angelo M. DeMarzo, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Sunila Pradeep, Youyou Zhang, Yan Xiang, Dahai Jiang, Xiaowen Hu, Zachary E. Stine, Lingegowda S. Mangala, Zhongyi Hu, Yunqi Lu
The MYC oncogene broadly promotes transcription mediated by all nuclear RNA polymerases, thereby acting as a positive modifier of global gene expression. Here, we report that MYC stimulates the transcription of DANCR, a long noncoding RNA (lncRNA) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e951c43e359e3de48fc631b96ad44bd
https://doi.org/10.1158/0008-5472.c.6509967.v1
https://doi.org/10.1158/0008-5472.c.6509967.v1
Autor:
Ben Z. Stanger, Chi V. Dang, Ophir Shalem, Ian A. Blair, Alexander Muir, Grace Croley, Colin Sheehan, Clementina Mesaros, Elaine S. Ho, Jimmy P. Xu, Miriam Doepner, Maimon Hubbi, Salina Yuan, Robert Norgard, Shivahamy Maheswaran, Jinyang Li, Yogev Sela
Solid tumors possess heterogeneous metabolic microenvironments where oxygen and nutrient availability are plentiful (fertile regions) or scarce (arid regions). While cancer cells residing in fertile regions proliferate rapidly, most cancer cells in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471700ee4594eb744658039acc1dc210
https://doi.org/10.1158/0008-5472.c.6513802
https://doi.org/10.1158/0008-5472.c.6513802
Autor:
Ben Z. Stanger, Chi V. Dang, Ophir Shalem, Ian A. Blair, Alexander Muir, Grace Croley, Colin Sheehan, Clementina Mesaros, Elaine S. Ho, Jimmy P. Xu, Miriam Doepner, Maimon Hubbi, Salina Yuan, Robert Norgard, Shivahamy Maheswaran, Jinyang Li, Yogev Sela
Supplementary Table from Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b4aab5440339ce7e6cd75f05a0fb89
https://doi.org/10.1158/0008-5472.22431109.v1
https://doi.org/10.1158/0008-5472.22431109.v1