Zobrazeno 1 - 10
of 1 391
pro vyhledávání: '"Chi V"'
Autor:
Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang, Hongguang Shao, Harsh Dweep, Yao-Yu Gong, Rebekah Brooks, Patricia Brafford, Adam J. Wolpaw, Yool Lee, Ashani Weeraratna, Amita Sehgal, Meenhard Herlyn, Andrew Kossenkov, David Speicher, Peter K. Sorger, Sandro Santagata, Chi V. Dang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells
Externí odkaz:
https://doaj.org/article/c859ff64da1345c9ad8da5b07e20c424
Autor:
Juliana Cazarin, Rachel E DeRollo, Siti Noor Ain Binti Ahmad Shahidan, Jamison B Burchett, Daniel Mwangi, Saikumari Krishnaiah, Annie L Hsieh, Zandra E Walton, Rebekah Brooks, Stephano S Mello, Aalim M Weljie, Chi V Dang, Brian J Altman
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010904 (2023)
The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expressio
Externí odkaz:
https://doaj.org/article/b1efa2e3f65441fdb44332215802b1db
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/074d71d5036b4a18bd4da6fc68944acc
Autor:
Annie L. Hsieh, Xiangzhong Zheng, Zhifeng Yue, Zachary E. Stine, Anthony Mancuso, Seth D. Rhoades, Rebekah Brooks, Aalim M. Weljie, Robert N. Eisenman, Amita Sehgal, Chi V. Dang
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1778-1788.e4 (2019)
Summary: Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the molecular clock in cancer cells. Here, we demonstrate that misregulation of dMyc
Externí odkaz:
https://doaj.org/article/3ea8bfb9495d43c99059d82693f0ca54
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133633 (2015)
The altered metabolism of cancer cells has long been viewed as a potential target for therapeutic intervention. In particular, brain tumors often display heightened glycolysis, even in the presence of oxygen. A subset of medulloblastoma, the most pre
Externí odkaz:
https://doaj.org/article/7a9cef5f4e4b4c939e03564119f37adf
Autor:
Utila, Masauko Henry, Lin, Hao-Wei, Chan, Hao-En, Ng, Jacob Wilder, Lin, Chun-Chieh, Badgujar, Pooja Manik, Cheng, Chia-Liang, Yeh, Wang-Chi V., Lin, Chu-Hsuan
Publikováno v:
In Materials Science in Semiconductor Processing January 2025 185
Autor:
Hongkai Ji, George Wu, Xiangcan Zhan, Alexandra Nolan, Cheryl Koh, Angelo De Marzo, Hoang Mai Doan, Jinshui Fan, Christopher Cheadle, Mohammad Fallahi, John L Cleveland, Chi V Dang, Karen I Zeller
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26057 (2011)
The functions of key oncogenic transcription factors independent of context have not been fully delineated despite our richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcription factor, is
Externí odkaz:
https://doaj.org/article/382795415c7445428a36108b48826f40
Autor:
Jinshui Fan, Karen Zeller, Yu-Chi Chen, Tonya Watkins, Kathleen C Barnes, Kevin G Becker, Chi V Dang, Chris Cheadle
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9691 (2010)
The definition of transcriptional networks through measurements of changes in gene expression profiles and mapping of transcription factor binding sites is limited by the moderate overlap between binding and gene expression changes and the inability
Externí odkaz:
https://doaj.org/article/e20606e098d646448cca5ff5e20ba829
Autor:
Tsuyoshi Iwata, Denise Schultz, Jessica Hicks, Gretchen K Hubbard, Laura N Mutton, Tamara L Lotan, Carlise Bethel, Matthew T Lotz, Srinivasan Yegnasubramanian, William G Nelson, Chi V Dang, MengMeng Xu, Uzoma Anele, Cheryl M Koh, Charles J Bieberich, Angelo M De Marzo
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9427 (2010)
Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate. However, prior studies have not determined precisely when, and in which cell types, MYC is
Externí odkaz:
https://doaj.org/article/59ed23f304684ff8b997f9f9164b889e