Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chi S. Ho"'
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote developme
Externí odkaz:
https://doaj.org/article/c90815da60ca4e659303d9709faffaad
Autor:
Kramer James Bernard, M.C. Holt, Stephen Douglas Barrett, Chi S. Ho, James Paul O'malley, Thomas A. Owen, Adam Uzieblo, Fred L. Ciske, A.J. Stein, Joseph Michael Colombo, María Inés Morano, Bradlee David Germain, Andrei M. Kornilov
Publikováno v:
Journal of Medicinal Chemistry. 62:4731-4741
A series of small-molecule full agonists of the prostaglandin E2 type 4 (EP4) receptor have been generated and evaluated for binding affinity and cellular potency. KMN-80 and its gem-difluoro analog KMN-159 possess high selectivity relative to other
Autor:
Kirk L, Olson, Melissa C, Holt, Fred L, Ciske, James B, Kramer, Paige E, Heiple, Margaret L, Collins, Carrie M, Johnson, Chi S, Ho, M Ines, Morano, Stephen D, Barrett
Publikováno v:
Bioorganicmedicinal chemistry letters. 34
In seeking novel and potent small molecule hematopoietic prostaglandin D
Autor:
Thomas A, Owen, Chandni, Patel, Shanqiao, Wei, Chi S, Ho, Kaylah, Birmingham, Samuel, Sanchez, Natalie, Chung, Alexa, Cahill, James P, O'Malley, Stephen D, Barrett, María Inés, Morano
Publikováno v:
Gene
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP(4) receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP(4) activation. KMN-159 is a potent, selective small m
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-14 (2019)
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote development of the
Autor:
Stephen D, Barrett, Melissa C, Holt, James B, Kramer, Bradlee, Germain, Chi S, Ho, Fred L, Ciske, Andrei, Kornilov, Joseph M, Colombo, Adam, Uzieblo, James P, O'Malley, Thomas A, Owen, Adam J, Stein, Maria I, Morano
Publikováno v:
Journal of medicinal chemistry. 62(9)
A series of small-molecule full agonists of the prostaglandin E
Autor:
Carrie M. Johnson, Margaret L. Collins, Fred L. Ciske, Kramer James Bernard, Kirk Lang Olson, Chi S. Ho, Stephen Douglas Barrett, M.C. Holt, M. Ines Morano, Paige E. Heiple
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 34:127759
In seeking novel and potent small molecule hematopoietic prostaglandin D2 synthase (H-PGDS) inhibitors as potential therapies for PGD2-mediated diseases and conditions, we explored a series comprising multiple aryl/heteroaryl rings attached in a line
Autor:
Stephen Douglas Barrett, Kaylah Birmingham, Alexa Cahill, Chandni Patel, James Paul O'malley, Shanqiao Wei, Samuel Sanchez, Thomas A. Owen, María Inés Morano, Natalie Chung, Chi S. Ho
Publikováno v:
Gene. 748:144668
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP4 receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP4 activation. KMN-159 is a potent, selective small molec
Autor:
Quanwen Li, Stephen I. Lentz, Stephen A. Ernst, Edward L. Stuenkel, Chi S. Ho, Svetlana E. Gladycheva, Jiang Liu, Yue Ying F. Lee
Publikováno v:
Journal of Biological Chemistry. 279:55924-55936
Syntaxin1A, a neural-specific N-ethylmaleimide-sensitive factor attachment protein receptor protein essential to neurotransmitter release, in isolation forms a closed conformation with an N-terminal alpha-helix bundle folded upon the SNARE motif (H3
Publikováno v:
The Journal of Physiology. 558:857-871
The formation and dissolution of SNARE protein complexes is essential for Ca2+-triggered fusion of neurotransmitter-filled vesicles at the presynaptic membrane. Among the pre-synaptic SNARE proteins, the activation of the Q-SNARE syntaxin1A is a crit