Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chi Leng Leong"'
Autor:
Adrian M. Nightingale, Chi Leng Leong, Rachel A. Burnish, Sammer-ul Hassan, Yu Zhang, Geraldine F. Clough, Martyn G. Boutelle, David Voegeli, Xize Niu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Continuous real-time measurement of biomarker levels in body fluids offers many exciting possibilities. Here, the authors develop an integrated wearable droplet microfluidic sensor that combines continuous sampling of tissue fluid with in situ analys
Externí odkaz:
https://doaj.org/article/90ea7d75a2df4f5290b5f864504a861c
Autor:
Paula Cunnea, Tommy Gorgy, Konstantinos Petkos, Sally A.N. Gowers, Haonan Lu, Cristina Morera, Wen Wu, Phillip Lawton, Katherine Nixon, Chi Leng Leong, Flavia Sorbi, Lavinia Domenici, Andrew Paterson, Ed Curry, Hani Gabra, Martyn G. Boutelle, Emmanuel M. Drakakis, Christina Fotopoulou
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC). In this study, we suggest that profiling
Externí odkaz:
https://doaj.org/article/cc3db571882b4b56b949edfb1aa0edd7
Autor:
Nicolas Moser, Yuanqi Hu, Chi Leng Leong, Martyn G. Boutelle, Pantelis Georgiou, Chiara Cicatiello, Sally A. N. Gowers
Publikováno v:
Analytical Chemistry
This work describes an array of 1024 ion-sensitive field-effect transistors (ISFETs) using sensor-learning techniques to perform multi-ion imaging for concurrent detection of potassium, sodium, calcium, and hydrogen. Analyte-specific ionophore membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca24fb863772dc734beeecedaa026dc0
https://pubmed.ncbi.nlm.nih.gov/32142259
https://pubmed.ncbi.nlm.nih.gov/32142259
Autor:
Adrian M. Nightingale, Martyn G. Boutelle, Xize Niu, Chi Leng Leong, Sharon Coleman, Sammer-ul Hassan, David Voegeli
We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from long-established homogeneous enzymatic assays require careful re-optimisation before their migration into miniaturised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43f70b85fb044e9343ddddaaa9d97e0
https://eprints.soton.ac.uk/435938/
https://eprints.soton.ac.uk/435938/
Autor:
Rachel A. Burnish, Martyn G. Boutelle, Yu Zhang, Geraldine F. Clough, David Voegeli, Adrian M. Nightingale, Sammer-ul Hassan, Xize Niu, Chi Leng Leong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a23a4e0314589b0a794c13886b2cc9
https://doi.org/10.1038/s41467-019-10401-y
https://doi.org/10.1038/s41467-019-10401-y
Autor:
Marsilea A. Booth, Isabelle C. Samper, Michelle L. Rogers, Chi Leng Leong, Aidan Wickham, Sally A. N. Gowers, Martyn G. Boutelle
Publikováno v:
Analytical chemistry. 90(1)
This review covers references found in the recent literature (from 2015) describing clinically relevant chemical monitoring that either gives continuous chemical information in real time or has the near prospect of doing so.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a299a5d9ab062f5d826be534de2b6f
https://pubmed.ncbi.nlm.nih.gov/29083872
https://pubmed.ncbi.nlm.nih.gov/29083872
Autor:
Erika L. Varner, Martyn G. Boutelle, Adrian C. Michael, Andrea Jaquins-Gerstl, Kathryn M. Nesbitt, Chi Leng Leong
Microdialysis is well established in chemical neuroscience as a mainstay technology for real time intracranial chemical monitoring in both animal models and human patients. The capabilities of microdialysis sampling have the potential to be further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c99103d2c82fc74f8206c3ca3107b12
http://hdl.handle.net/10044/1/49128
http://hdl.handle.net/10044/1/49128
Publikováno v:
ISCAS
We demonstrate a CMOS-based lab-on-chip platform which is capable of ion imaging to detect a variation in hydrogen, potassium and sodium ions. An ISFET array is used to detect a change in ion concentration with a calibration scheme to cancel the offs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30125e6c2f70f71bdf13c6bd4e55614
https://doi.org/10.1109/iscas.2017.8050722
https://doi.org/10.1109/iscas.2017.8050722
Autor:
T. K. Mellor, Martyn G. Boutelle, Peter A. Brennan, Chi Leng Leong, T. Aldridge, Sally A. N. Gowers, Michelle L. Rogers
Publikováno v:
Analytical and Bioanalytical Chemistry
We describe an enzyme-based electroanalysis system for real-time analysis of a clinical microdialysis sampling stream during surgery. Free flap tissue transfer is used widely in reconstructive surgery after resection of tumours or in other situations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4d5a3fee826dd7644081c73da0d2b3
https://doi.org/10.1007/s00216-013-6770-z
https://doi.org/10.1007/s00216-013-6770-z
Publikováno v:
ISCAS
In this paper, we present a novel approach to ISFET arrays which allows the conception of ion imaging Lab-on-CMOS platforms. K+ and Na+ selective polymer membranes are deposited on the surface of the array so that each pixel is selective to a particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813514db292656c23be0594ac5b0c5e9
https://doi.org/10.1109/iscas.2016.7539186
https://doi.org/10.1109/iscas.2016.7539186