Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chi Hsin R. King"'
Autor:
Ismail Mitha, Andrè J. Bester, Ming-Chu Hsu, Ren-Guang Wu, Dirkie Johanna Van Rensburg, Reury-Perng Perng, Ming-Lin Ho, Joseph Kasumba, Yu-Ting Chang, Chi-Hsin R. King, David T. Chung, Li-Wen Chang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:4098-4106
Nemonoxacin, a novel nonfluorinated quinolone, exhibits potent in vitro and in vivo activities against community-acquired pneumonia (CAP) pathogens, including multidrug-resistant Streptococcus pneumoniae . Patients with mild to moderate CAP ( n = 265
Autor:
Karen L. Huss, Charles R. Heap, William T. McMillen, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer, Robert M. Campbell, Matthew D. Voss, Bryan D. Anderson, Chi Hsin R. King, Elizabeth A. Dierks, Hong Yu Li, Wang Yan, Lei Yan, Sreenivasa Reedy Mundla, Karen S. Britt, Denis J. McCann
Publikováno v:
Journal of Medicinal Chemistry. 51:2302-2306
In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in
Publikováno v:
Synthesis. 2006:2743-2747
An efficient synthesis of the side-chain precursor crucial to the preparation of 18-methoxycoronaridine (18-MC) has been developed. This procedure represents an improvement upon the original synthesis, in which regioisomers were separated by chromato
Autor:
Charles R. Heap, Jill R. Wagner, Lei Yan, Sreenivasa Reedy Mundla, Wang Yan, William T. McMillen, Ku X. Lu, David K. Clawson, Bryan D. Anderson, Chi Hsin R. King, Hong Yu Li, Karen S. Britt, Robert M. Campbell, Jonathan M. Yingling, Matthew Ernst Voss
Publikováno v:
Journal of Medicinal Chemistry. 49:2138-2142
Novel dihydropyrrolopyrazole-substituted benzimidazoles were synthesized and evaluated in vitro as inhibitors of transforming growth factor-beta type I receptor (TGF-beta RI), TGF-beta RII, and mixed lineage kinase-7 (MLK-7). These compounds were fou
Autor:
Brian T. Gregg, Zinovy Itov, Mark A Helle, Harold Meckler, Joyce C. Knutson, Mary E. Mateo, William B. Geiss, Lisa D. Coutts, Mark W. Zettler, Chi-Hsin R. King
Publikováno v:
Organic Process Research & Development. 6:246-255
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), wh...
Autor:
Isabelle M. Maisonneuve, R. Jason Herr, Harold Meckler, Chi-Hsin R. King, Stanley D. Glick, Michael P. Trova
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:473-476
Chemical resolution of racemic 18-methoxycoronaridine (18-MC) was achieved by the formation of its diastereomeric sulfonamides with either (R)-(-)- or (S)-(+)-camphorsulfonyl chloride. Preliminary assessment of (+)-, (-)-, and (+/-)-18-MC x HCl showe
Publikováno v:
Synthetic Communications. 26:2213-2221
A convenient route to previously unknown 8-acylated castanospermines is illustrated by synthesis of the butyryl derivative.
Autor:
Chi-Hsin R. King, Alexey L. Margolin
Publikováno v:
Tetrahedron: Asymmetry. 4:943-946
A new technique - immobilzation of substrates on solid supports - was applied to the synthesis of a new potent optically pure serotonin receptor antagonist.
Publikováno v:
ChemInform. 27
A convenient route to previously unknown 8-acylated castanospermines is illustrated by synthesis of the butyryl derivative.
Autor:
Chi-Hsin R. King, Philip M. Weintraub
Publikováno v:
ChemInform. 28