Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Chi Hin Cho"'
Autor:
Min Yang, Qianxiu Li, Huan Yang, Yifan Li, Lan Lu, Xu Wu, Yubin Liu, Wanping Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Yu Chen, Shuai Deng, Chi Hin Cho, Xiaobing Li, Mingxing Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116336- (2024)
Objective: Protein disulfide isomerase A3 (PDIA3) promotes the correct folding of newly synthesized glycoproteins in the endoplasmic reticulum. PDIA3 is overexpressed in most tumors, and it may become a biomarker of cancer prognosis and immunotherapy
Externí odkaz:
https://doaj.org/article/f473c836effb4376a195eca9f80c9f86
Autor:
Wenxiu Zhang, Zaofeng Yang, Jiale Zheng, Kaili Fu, Jack Ho Wong, Yunbi Ni, Tzi Bun Ng, Chi Hin Cho, Michael K. Chan, Marianne M. Lee
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Helicobacter pylori (H. pylori) causes infection in the stomach and is a major factor for gastric carcinogenesis. The application of antimicrobial peptides (AMPs) as an alternative treatment to traditional antibiotics is limited by their fac
Externí odkaz:
https://doaj.org/article/20d543b4651740d89077bc1f831a2647
Autor:
Yu Chen, Qingfan Yang, Jinrun Xu, Liyao Tang, Yan Zhang, Fukuan Du, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Ruilin Ding, Hongying Cao, Wanping Li, Xiaobing Li, Meijuan Chen, Zhigui Wu, Chi Hin Cho, Yu Du, Qinglian Wen, Zhangang Xiao
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 204-223 (2022)
Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase ligand covalently linked to a protein of interest (POI) via a linker. PROTAC c
Externí odkaz:
https://doaj.org/article/bf708ce6e296413ebb56d0b8ba2f42f4
Autor:
Yu Chen, Fukuan Du, Liyao Tang, Jinrun Xu, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Qinglian Wen, Chi Hin Cho, Zhangang Xiao
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 400-416 (2022)
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery. Based
Externí odkaz:
https://doaj.org/article/e5c28f0d79564bdabbee8f4941a4f657
Autor:
Xiaoxiao Wu, Shengpeng Wang, Mingxing Li, Jing Li, Jing Shen, Yueshui Zhao, Jun Pang, Qinglian Wen, Meijuan Chen, Bin Wei, Parham Jabbarzadeh Kaboli, Fukuan Du, Qijie Zhao, Chi Hin Cho, Yitao Wang, Zhangang Xiao, Xu Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1360-1381 (2020)
Long-term primary culture of mammalian cells has been always difficult due to unavoidable senescence. Conventional methods for generating immortalized cell lines usually require manipulation of genome which leads to change of important biological and
Externí odkaz:
https://doaj.org/article/551e8db3f9f24bf1a810326fee42b624
Autor:
Yueshui Zhao, Qijie Zhao, Parham Jabbarzadeh Kaboli, Jing Shen, Mingxing Li, Xu Wu, Jianhua Yin, Hanyu Zhang, Yuanlin Wu, Ling Lin, Lingling Zhang, Lin Wan, Qinglian Wen, Xiang Li, Chi Hin Cho, Tao Yi, Jing Li, Zhangang Xiao
Publikováno v:
Translational Oncology, Vol 12, Iss 10, Pp 1323-1333 (2019)
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification. However, little is known about both its influence and biogenesis in tumor development
Externí odkaz:
https://doaj.org/article/0c5c187891e34b1eb600e174cdcabe21
Autor:
Xu Wu, Wei Hu, Lan Lu, Yueshui Zhao, Yejiang Zhou, Zhangang Xiao, Lin Zhang, Hanyu Zhang, Xiaobing Li, Wanping Li, Shengpeng Wang, Chi Hin Cho, Jing Shen, Mingxing Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 203-219 (2019)
Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components. Recent epidemiological and clinical studies strong
Externí odkaz:
https://doaj.org/article/ea3b860f728f4941a2e1c73cd1e7d8db
Autor:
Zhu Wang, Jianhua Yin, Mingxing Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Chengliang Huang, Hanyu Zhang, Zhuo Zhang, Chi Hin Cho, Xu Wu
Publikováno v:
Chinese Medicine, Vol 14, Iss 1, Pp 1-11 (2019)
Abstract Background Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN ca
Externí odkaz:
https://doaj.org/article/bcab7f934055497095e92692fa349f09
Autor:
Shixin Xiang, Jing Li, Jing Shen, Yueshui Zhao, Xu Wu, Mingxing Li, Xiao Yang, Parham Jabbarzadeh Kaboli, Fukuan Du, Yuan Zheng, Qinglian Wen, Chi Hin Cho, Tao Yi, Zhangang Xiao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The efficacy of immunotherapy usually depends on the interaction of immunomodulation in the tumor microenvironment (TME). This study aimed to explore
Externí odkaz:
https://doaj.org/article/dd696fee1d2d4bc0922dba1fcc05097b
Autor:
Huimin Huang, Mingxing Li, Yi Wang, Xiaoxiao Wu, Jing Shen, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Yu Chen, Zhigui Wu, Huijiao Ji, Chunyuan Zhang, Jing Li, Qinglian Wen, Parham Jabbarzadeh Kaboli, Chi Hin Cho, Shengpeng Wang, Yitao Wang, Yisheng He, Xu Wu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Longan is the fruit of Dimocarpus longan Lour. and the longan arillus has long been used in traditional Chinese medicine possessing various health benefits. However, the excessive intake of longan is found in daily life to cause “shangh
Externí odkaz:
https://doaj.org/article/1a64b13287884603a75960d93adf9894