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pro vyhledávání: '"Chi H. Mak"'
Autor:
Chi H. Mak
Publikováno v:
ACS Physical Chemistry Au, Vol 4, Iss 2, Pp 180-190 (2024)
Externí odkaz:
https://doaj.org/article/b24a60ddcb134237a93f3608410f21c0
Autor:
Malgorzata M Jaszczur, Dan D Vo, Ramunas Stanciauskas, Jeffrey G Bertram, Adhirath Sikand, Michael M Cox, Roger Woodgate, Chi H Mak, Fabien Pinaud, Myron F Goodman
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007956 (2019)
Mutagenic translesion DNA polymerase V (UmuD'2C) is induced as part of the DNA damage-induced SOS response in Escherichia coli, and is subjected to multiple levels of regulation. The UmuC subunit is sequestered on the cell membrane (spatial regulatio
Externí odkaz:
https://doaj.org/article/ef8f932d641746228ebffdddf2647dab
Autor:
Debika Ojha, Malgorzata M Jaszczur, Adhirath Sikand, John P McDonald, Andrew Robinson, Antoine M van Oijen, Chi H Mak, Fabien Pinaud, Michael M Cox, Roger Woodgate, Myron F Goodman
Publikováno v:
Nucleic Acids Research. 50:6854-6869
Homologs of the mutagenic Escherichia coli DNA polymerase V (pol V) are encoded by numerous pathogens and mobile elements. We have used Rum pol (RumA′2B), from the integrative conjugative element (ICE), R391, as a model mobile element-encoded polym
Autor:
Ethan N.H. Phan, Chi H. Mak
Publikováno v:
Biophysical Journal. 120:2343-2354
Trinucleotide repeat expansion disorders are associated with the overexpansion of (CNG) repeats on the genome. Messenger RNA transcripts of sequences with greater than 60-100 (CNG) tandem units have been implicated in trinucleotide repeat expansion d
Autor:
Chi H. Mak
Publikováno v:
The Journal of chemical physics. 156(17)
Performing full-resolution atomistic simulations of nucleic acid folding has remained a challenge for biomolecular modeling. Understanding how nucleic acids fold and how they transition between different folded structures as they unfold and refold ha
Autor:
Chi H. Mak, Lilly Mai, Juan Pablo De Los Rios, Seungwon Lee, Mythreyi Rayaluru, Anna Schusser, Jessica L. Andrews
Publikováno v:
Journal of Chemical Education
During the COVID-19 pandemic, an at-home laboratory program was created and implemented for a section of the general chemistry course at the University of Southern California. The experiments were designed to only utilize safe household items and no
Publikováno v:
The Journal of Physical Chemistry A. 123:3030-3037
Activation-induced deoxycytidine deaminase (AID) is a key enzyme in the human immune system. AID binds to and catalyzes random point mutations on the immunoglobulin (Ig) gene, leading to diversification of the Ig gene sequence by random walk motions,
Autor:
Chi H. Mak
Publikováno v:
The Journal of Physical Chemistry B. 123:1939-1949
Ultrahigh-throughput conformational sampling of biopolymers like nucleic acids are most effectively carried out without explicit solvents, but the physical origins of almost all inter- and intramolecular interactions controlling nucleic acid structur
Autor:
Rongpeng Li, Chi H. Mak
Base pairing plays a pivotal role in DNA functions and replication fidelity. But while the complementarity between Watson-Crick matched bases is generally believed to arise from the different number of hydrogen bonds in G|C pairs versus A|T, the ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf36744213d951bfb459604ac2294ae4
https://doi.org/10.1101/2020.06.04.134981
https://doi.org/10.1101/2020.06.04.134981
Autor:
Chi H. Mak, Phan Enh
Trinucleotide repeat expansion disorders (TRED) are associated with the overexpansion of (CNG) repeats on the genome. mRNA transcripts of sequences with greater than 60 to 100 (CNG) tandem units have been implicated in TRED pathogenesis. In this pape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4a4321b0a343195be261a0593debfb
https://doi.org/10.1101/2020.05.30.125641
https://doi.org/10.1101/2020.05.30.125641