Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chi G Weindel"'
Autor:
Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick
Publikováno v:
eLife, Vol 11 (2022)
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcom
Externí odkaz:
https://doaj.org/article/6d3c3ed1193744ab8bd751412b25e522
Autor:
Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Publikováno v:
eLife, Vol 9 (2020)
The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggest
Externí odkaz:
https://doaj.org/article/4caa4bf04ba84861995ba7c4bd7c84fd
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Despite major strides in personalized genomics, it remains poorly understood why neurodegenerative diseases occur in only a fraction of individuals with a genetic predisposition and conversely, why individuals with no genetic risk of a disorder devel
Externí odkaz:
https://doaj.org/article/7ef31ad37ecb4f4985b0f73323654c76
Autor:
Sikandar Azam, Kaitlyn S. Armijo, Chi G. Weindel, Alice Devigne, Shinichi Nakagawa, Tetsuro Hirose, Susan Carpenter, Robert O. Watson, Kristin L. Patrick
There is a growing appreciation for membraneless organelles (MLOs) in regulating cellular stress responses. Here, we demonstrate a role for the nuclear paraspeckle, a highly ordered biomolecular condensate that nucleates on theNeat1lncRNA, in both ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17aa49a7dfb3a6b4928aa3636a906f0c
https://doi.org/10.1101/2023.05.11.540384
https://doi.org/10.1101/2023.05.11.540384
Publikováno v:
Trends in Cell Biology.
Autor:
Jason Karpac, Baoyu Zhao, Pingwei Li, Chi G Weindel, Cory Mabry, Kristin L. Patrick, Eduardo R. Martinez, Phillip West, Aja K. Coleman, Jordan J VanPortfliet, Krystal J Vail, Xiao Zhao, Robert O. Watson, Samantha L Bell
SUMMARYHuman mutations in mitochondrial-associated genes are associated with inflammatory diseases and susceptibility to infection. However, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e2f7252780f4ed937aacbe248e920a
https://doi.org/10.1101/2021.11.18.469014
https://doi.org/10.1101/2021.11.18.469014
Autor:
Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson
Publikováno v:
Cell. 185:3214-3231.e23
Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele
Publikováno v:
The Journal of Immunology. 198:1081-1092
Individuals suffering from autoimmune disorders possess a hyperactive cellular phenotype where tolerance to self-antigens is lost. Autophagy has been implicated in both the induction and prevention of autoimmunity, and modulators of this cellular rec