Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chi D. Hornik"'
Autor:
Benjamin T. Cocanougher, Samuel W. Liu, Ludmila Francescatto, Alexander Behura, Mariele Anneling, David G. Jackson, Kristen L. Deak, Chi D. Hornik, Mai K. ElMallah, Carolyn E. Pizoli, Edward C. Smith, Khoon Ghee Queenie Tan, Marie T. McDonald
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100288- (2024)
Summary: Biallelic loss-of-function variants in the MUSK gene result in two allelic disorders: (1) congenital myasthenic syndrome (CMS; OMIM: 616325), a neuromuscular disorder that has a range of severity from severe neonatal-onset weakness to mild a
Externí odkaz:
https://doaj.org/article/62fbd441e8164dd983e840f993fde9d1
Autor:
Jason E. Lang, Chi D. Hornik, Karen Martz, Juliana Jacangelo, Ravinder Anand, Rachel Greenberg, Christoph Hornik, Kanecia Zimmerman, P. Brian Smith, Daniel K. Benjamin, Matthew Laughon
Publikováno v:
Contemporary Clinical Trials Communications, Vol 30, Iss , Pp 101025- (2022)
Bronchopulmonary dysplasia (BPD) is a disease of chronic respiratory insufficiency stemming from premature birth and iatrogenic lung injury leading to alveolar simplification, impaired alveolar-capillary development, interstitial fibrosis, and often
Externí odkaz:
https://doaj.org/article/7620abb4d1534fd4ad1981a3fec1c5b2
Autor:
Eleni Karatza, Samit Ganguly, Chi D. Hornik, William J. Muller, Amira Al-Uzri, Laura James, Stephen J. Balevic, Daniel Gonzalez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Risperidone is approved to treat schizophrenia in adolescents and autistic disorder and bipolar mania in children and adolescents. It is also used off-label in younger children for various psychiatric disorders. Several population pharmacokinetic mod
Externí odkaz:
https://doaj.org/article/1e401b42d0c7455caf1a8461cdd9224a
Autor:
Mara L. Becker, Gwenyth Fischer, Chi D. Hornik, Omar Alibrahim, Kelechi Iheagwara, Kamal Abulebda, Andora L. Bass, Katherine Irby, Anjali Subbaswamy, Elizabeth E. Zivick, Jill Sweney, Anne G. Stormorken, Erin E. Barker, Shruthi Mahadaveiah, Riad Lutfi, Michael C. McCrory, John M. Costello, Kate G. Ackerman, Jennifer C. Munoz-Pareja, Bryan J. Feger, J. Michael Dean, Daniel F. Hanley, Rachel G. Greenberg, Radhika Avadhani, Richard E. Thompson, Daniel K. Benjamin, Christoph P. Hornik, Kanecia O. Zimmerman
Publikováno v:
Journal of Pediatric Intensive Care.
Objectives This article observes the mean daily dose of fentanyl required for adequate sedation in critically ill, mechanically ventilated children randomized to receive dexmedetomidine or placebo. Methods We conducted Dexmedetomidine Opioid Sparing
Autor:
Dan L. Stewart, Daniel Gonzalez, Namasivayam Ambalavanan, Andrew M. Atz, Wesley M. Jackson, Gregory M Sokol, Michael Cohen-Wolkowiez, Brenda B. Poindexter, Mary Mills, Chi D. Hornik, Karen Martz, Shawn K. Ahlfeld, Matthew M. Laughon, Christoph P. Hornik, Gratias Mundakel, P. Brian Smith
Publikováno v:
Journal of Perinatology
Objective To characterize the safety of sildenafil in premature infants. Study design A phase I, open-label trial of sildenafil in premature infants receiving sildenafil per usual clinical care (cohort 1) or receiving a single IV dose of sildenafil (
Autor:
Rima Snariene, Hans Georg Münch, Anne Smits, Christopher M. Rubino, Arunas Liubsys, Karine Litherland, Tomasz Tomasik, Kamal Hamed, Dace Gardovska, Chi D. Hornik, Mark J Polak, Przemko Kwinta, Veerle Cossey, Sebastian Schröpf, Christine Ruehle, Miroslava Bosheva
Publikováno v:
The Pediatric Infectious Disease Journal
Pediatric infectious disease journal, Philadelphia : Lippincott Williams and Wilkins, 2021, vol. 40, no. 11, p. 997-1003
Pediatric infectious disease journal, Philadelphia : Lippincott Williams and Wilkins, 2021, vol. 40, no. 11, p. 997-1003
Supplemental Digital Content is available in the text.
Background: Ceftobiprole, the active moiety of the prodrug ceftobiprole medocaril, is an advanced-generation, broad-spectrum, intravenous cephalosporin, which is currently approved for the t
Background: Ceftobiprole, the active moiety of the prodrug ceftobiprole medocaril, is an advanced-generation, broad-spectrum, intravenous cephalosporin, which is currently approved for the t
Autor:
Angelique E. Boutzoukas, Rachel Olson, Mary Ann Sellers, Gwenyth Fischer, Chi D. Hornik, Omar Alibrahim, Kelechi Iheagwara, Kamal Abulebda, Andora L. Bass, Katherine Irby, Anjali Subbaswamy, Elizabeth E. Zivick, Jill Sweney, Anne G. Stormorken, Erin E. Barker, Riad Lutfi, Michael C. McCrory, John M. Costello, Kate G. Ackerman, Jennifer C. Munoz Pareja, J. Michael Dean, Nael Abdelsamad, Daniel F. Hanley, W. Andrew Mould, Karen Lane, Mary Stroud, Bryan J. Feger, Rachel G. Greenberg, P. Brian Smith, Daniel K. Benjamin, Christoph P. Hornik, Kanecia O. Zimmerman, Mara L. Becker
Publikováno v:
Contemporary Clinical Trials. 125:107067
Timely trial start-up is a key determinant of trial success; however, delays during start-up are common and costly. Moreover, data on start-up metrics in pediatric clinical trials are sparse. To expedite trial start-up, the Trial Innovation Network p
Autor:
Rachel G. Greenberg, P. Brian Smith, Daniel K. Benjamin, Reese H. Clark, Carl L. Bose, Chi D. Hornik, Chris DeRienzo, Laura E Miller, C. Michael Cotten
Publikováno v:
Journal of Perinatology. 41:1739-1744
Objective Determine the associations between neonatal intensive care unit (NICU) medication safety practices, laboratory-based adverse events (lab-AEs), and death. Study design We combined data from a 2016 survey of Pediatrix NICUs on use of medicati
Autor:
Chiara Melloni, Amira Al-Uzri, Felix Boakye-Agyeman, Susan R. Mendley, Sarah Jane Commander, Barrie Harper, Chi D. Hornik, Kanecia O. Zimmerman, Michael Cohen-Wolkowiez, Christoph P. Hornik, Huali Wu
Publikováno v:
J Clin Pharmacol
Hydrochlorothiazide (HCTZ) is a thiazide diuretic used in adults and children for the treatment of hypertension and edema. The pharmacokinetic (PK) properties of HCTZ in children are not well characterized, particularly among children with obesity wh
Autor:
Jacqueline G Gerhart, Dan L. Stewart, Namasivayam Ambalavanan, Gregory M Sokol, Daniel Gonzalez, Matthew M. Laughon, Chi D. Hornik, Andrea N. Edginton, Sara Salerno, Mary Mills, Karen Martz
Publikováno v:
Clinical pharmacology and therapeutics
Physiologically-based pharmacokinetic (PBPK) modeling can potentially predict pediatric drug-drug interactions (DDIs) when clinical DDI data are limited. In infants for whom treatment of pulmonary hypertension and prevention or treatment of invasive