Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Chi Chung Chan"'
Autor:
Hou Hon Cheong, Fong I Sio, Chi Chung Chan, Seong In Neng, Ip Pio Sam, Teng Cheang, Weng Ieong Tou, Hong San Lei, Tan Fong Cheong, Edmundo Patricio Lopes Lao, Tak Hong Cheong, Cheong U Kuok, Iek Long Lo
Publikováno v:
Health Science Reports, Vol 6, Iss 7, Pp n/a-n/a (2023)
Abstract Background and Aims The evolving mutants of SARS‐CoV‐2 have made the COVID‐19 pandemic sustained for over 3 years. In 2022, BA.4 and BA.5 were the Omicron variants dominating the spread globally. Although COVID‐19 was no longer a Pub
Externí odkaz:
https://doaj.org/article/937bbedd4a7f49aeb8d9396ac8f0bf2d
Autor:
Meirong Du, Qing Qiu, Andree Gruslin, John Gordon, Miao He, Chi Chung Chan, Dajin Li, Benjamin K Tsang
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54572 (2013)
Recent evidence indicates that CXCR2 signaling is crucial for cancer progression, and its antagonist SB225002 induces apoptosis in Wilms' tumor cells. Here, we investigated the effect of SB225002 on cell cycle progression and apoptosis induction in v
Externí odkaz:
https://doaj.org/article/2f2cc0ff5fe348f7bcc62ad7e95ea53a
Autor:
Jianyu Lu, Chi-chung Chan, Deheng Sun, Guoping Hu, Huijun He, Jian Li, Jiaqiang Dong, Kai Liu, Liang Shen, Lihong Hu, Qingyang Gu, Shuhui Chen, Tielin Wang, Ting Gong, Wei Tang, Xiaoting Li, Xiaotong Zhu, Xu Zeng, Yingjie Zhu, Yuanfeng Xia, Yuanyuan Huang, Yusong Zhu, Zhenteng Liu, Charles Z. Ding
Publikováno v:
Bioorganicmedicinal chemistry letters. 66
We previously described the discovery of a novel indole series compounds as oral SERD for ER positive breast cancer treatment. Further SAR exploration focusing on substitutions on indole moiety of compound 12 led to the discovery of a clinical candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779cdbe0aa50e8bfeeb02f9f638c3291
https://pubmed.ncbi.nlm.nih.gov/35436589
https://pubmed.ncbi.nlm.nih.gov/35436589
Autor:
Gianni Panagiotou, Thomas S. Y. Chan, Paul P. Lee, Bonnie Kho, Sze-Fai Yip, Chi-Kuen Lau, Wa Li, Herbert Pang, Vivien Mak, Joycelyn Sim, Edmond S. K. Ma, Yok-Lam Kwong, Harold K. K. Lee, Rita Yim, Ho-Wan Ip, Raymond S.M. Wong, Albert K. W. Lie, Shek‐Yin Lin, Harinder Gill, June S. M. Lau, Jun Li, Chi-Chung Chan, Yu-Yan Hwang, Rock Y. Y. Leung, Garret M. K. Leung
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 10, Pp 3371-3382 (2020)
Cancer Medicine, Vol 9, Iss 10, Pp 3371-3382 (2020)
Clofarabine is active in refractory/relapsed acute myeloid leukemia (AML). In this phase 2 study, we treated 18‐ to 65‐year‐old AML patients refractory to first‐line 3 + 7 daunorubicin/cytarabine induction or relapsing after 3 + 7 induction a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e1b9bb7e961ef53889aeaa1c979d54
http://europepmc.org/articles/PMC7221314
http://europepmc.org/articles/PMC7221314
Autor:
France Landry, Chi-Chung Chan, Zheng Huang, Gregoire Leclair, Chun Sing Li, Renata Oballa, Lei Zhang, Kevin Bateman
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1494-1499 (2011)
A positive correlation between stearoyl-CoA desaturase (SCD)1 expression and metabolic diseases has been reported in rodents and humans. These findings indicate that SCD1 is a promising therapeutic target for the chronic treatment of diabetes and dys
Externí odkaz:
https://doaj.org/article/178cedb1da654512987a2eb22e2b1874
Autor:
Chen Shuhui, Hu Lihong, Yuanfeng Xia, Tian Xin, Charles Z. Ding, Li Gang, Chi-Chung Chan, Ling Yang, Zhong xiong, Xiquan Zhang
Publikováno v:
Cancer Research. 81:1970-1970
Objective: Cell division cycle 7 (CDC7), a receptor serine/threonine kinase which features high-affinity with protein DBF4, plays an important role in DNA replication and DNA damage response via MCM2 phosphorylation. CDC7 has been reported to be up-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9199753aa7d574e3bb02777d2ca96904
https://doi.org/10.1158/1538-7445.am2021-1970
https://doi.org/10.1158/1538-7445.am2021-1970
Autor:
Hu Lihong, Chen Shuhui, Tingting Song, Chi-Chung Chan, Yuanfeng Xia, Haijun Tong, Fu Xiangyu, Shuhua Han, Ying Chen, Charles Z. Ding, Shaohua Qin, Hongyu Chen, Jian Zuo, Min Sun
Publikováno v:
Cancer Research. 81:2291-2291
Background: Transforming growth factor-β (TGF-β) plays a significant role in multiple physiological signaling pathways, thus occupies a pivotal position in balancing immunity and antigen tolerance. Activation of TGFβ type I receptor (TGF-βRI) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3acd82b231087a2c601c248f346961fa
https://doi.org/10.1158/1538-7445.am2021-2291
https://doi.org/10.1158/1538-7445.am2021-2291
Autor:
Clarence C.K. Lam, Chi-Chung Chan, Harinder Gill, Cyrus R. Kumana, June S. M. Lau, Ho-Wan Ip, Vivien Mak, Harold K. K. Lee, Yu-Yan Hwang, Rita Yim, Chi-Kuen Lau, Raymond S.M. Wong, Wa Li, Rock Y. Y. Leung, Bonnie Kho, Sze-Fai Yip, Thomas S. Y. Chan, Shek‐Yin Lin, Yok-Lam Kwong
Publikováno v:
Cancer. 125(17)
BACKGROUND Strategies using oral arsenic trioxide (As2 O3 ) are efficacious in relapsed acute promyelocytic leukemia (APL), but they have not been examined in newly diagnosed cases. METHODS Sixty-two consecutive patients (24 men and 38 women) with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3d5f7ae64361ef87a2d1f66e8f4662
https://pubmed.ncbi.nlm.nih.gov/31090936
https://pubmed.ncbi.nlm.nih.gov/31090936
Autor:
Hongyang Wang, Ziliang Qian, Mao Mao, Chi-Chung Chan, Douglas D. Fang, Hongye Sun, Chen Shuhui, Xiaowei Xu, Qiang Xu, Yuxin Qin, Yuhong Shen, Shuqun Yang, Yexiong Tan, Chonglin Luo, Guan Wang, Qingyang Gu
Publikováno v:
Oncotarget
Hepatocellular carcinoma (HCC) is the fifth most common type of cancers worldwide. However, current therapeutic approaches for this epidemic disease are limited, and its 5-year survival rate hasn't been improved in the past decades. Patient-derived x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b7b908d42b29be14fcd2410f5ae132
https://doi.org/10.18632/oncotarget.6684
https://doi.org/10.18632/oncotarget.6684
Autor:
Wang Tie-Lin, Charles Z. Ding, Deheng Sun, Yingjie Zhu, Yuanfeng Xia, Chen Shuhui, Liang Shen, Qingyang Gu, Xiaoting Li, He Huijun, Lu Jianyu, Dong Jiaqiang, Hu Guoping, Chi-Chung Chan, Jian Li, Hu Lihong, Xu Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127601
Most estrogen receptor positive (ER +) breast cancers depend on ER signaling pathway to develop. Clinical application of SERD fulvestrant effectively degraded ER, blocked its function and prolonged progression free survival of ER + breast cancer pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dce2ec97ba72df586b2c4e54023a895
https://doi.org/10.1016/j.bmcl.2020.127601
https://doi.org/10.1016/j.bmcl.2020.127601