Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Chi C. Wong"'
1
Akademický článek
eIF6 rebinding dynamically couples ribosome maturation and translation
Autor: Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C. Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J. Adams, Alan J. Warren
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.
Externí odkaz: https://doaj.org/article/453b7a70084349bea9b8597caaa6ef1f
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2
Akademický článek
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
Autor: Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis lead
Externí odkaz: https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
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4
Data from Aerosol Administration of Phospho-Sulindac Inhibits Lung Tumorigenesis
Autor: Basil Rigas, Timothy Wiedmann, Gang Xie, Nengtai Ouyang, Liqun Huang, Gerardo G. Mackenzie, Ninche Alston, Chi C. Wong, Ka Wing Cheng
Phospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindac might overcome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4c32100c236fed9746ecb80127bdb0
https://doi.org/10.1158/1535-7163.c.6536460.v1
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7
eIF6 rebinding dynamically couples ribosome maturation and translation
Autor: Pablo Castro-Hartmann, Shengjiang Tan, Penny Wright, David J. Adams, Alexandre Faille, Christine Hilcenko, Norberto Escudero-Urquijo, Pekka Jaako, Alan J. Warren, Chi C. Wong
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1 (both mutated in the leukaemia predisposition disorder Shwachman-Diamond syndrome) license
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e45e8774752f2a669f538203b3da057
https://doi.org/10.1101/2021.09.06.459071
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8
Akademický článek
Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect.
Autor: Liqun Huang, Chi C Wong, Ka W Cheng, Basil Rigas
Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111720 (2014)
Phospho-aspirin (PA-2) is a novel aspirin derivative that exhibits promising anticancer properties and is considerably safer than conventional aspirin. In this study, we investigated the chemotherapeutic efficacy of PA-2 in preclinical models of estr
Externí odkaz: https://doaj.org/article/d62bd4df17934e9686c614a106da7e0c
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9
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
Autor: Patrick Thomas, David J. Adams, Chi C. Wong, Emmanuelle Supper, Saskia S. Rudat, Vivek Iyer, Alastair Droop, Jean-François Spinella, Guy Sauvageau, Kim Wong
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive responses. Whether tumor suppressor gene haploinsufficiency leads to such phenomena and their
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5880e4e9d61ba558263d4dacc9fd4d7b
https://doi.org/10.1038/s41467-021-22750-8
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