Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chi C Wong"'
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111720 (2014)
Phospho-aspirin (PA-2) is a novel aspirin derivative that exhibits promising anticancer properties and is considerably safer than conventional aspirin. In this study, we investigated the chemotherapeutic efficacy of PA-2 in preclinical models of estr
Externí odkaz:
https://doaj.org/article/d62bd4df17934e9686c614a106da7e0c
Autor:
Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C. Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J. Adams, Alan J. Warren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.
Externí odkaz:
https://doaj.org/article/453b7a70084349bea9b8597caaa6ef1f
Autor:
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis lead
Externí odkaz:
https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
Autor:
Basil Rigas, Timothy Wiedmann, Gang Xie, Nengtai Ouyang, Liqun Huang, Gerardo G. Mackenzie, Ninche Alston, Chi C. Wong, Ka Wing Cheng
PDF file - 883K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157869e68c06019d5f87b3d24721f786
https://doi.org/10.1158/1535-7163.22500456
https://doi.org/10.1158/1535-7163.22500456
Autor:
Basil Rigas, Timothy Wiedmann, Gang Xie, Nengtai Ouyang, Liqun Huang, Gerardo G. Mackenzie, Ninche Alston, Chi C. Wong, Ka Wing Cheng
Phospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindac might overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4c32100c236fed9746ecb80127bdb0
https://doi.org/10.1158/1535-7163.c.6536460.v1
https://doi.org/10.1158/1535-7163.c.6536460.v1
Autor:
Irving, Simonin-Wilmer, Raul, Ossio, Emmett M, Leddin, Mark, Harland, Karen A, Pooley, Mauricio Gerardo, Martil de la Garza, Sofia, Obolenski, James, Hewinson, Chi C, Wong, Vivek, Iyer, John C, Taylor, Julia A, Newton-Bishop, D Timothy, Bishop, Gerardo Andrés, Cisneros, Mark M, Iles, David J, Adams, Carla Daniela, Robles-Espinoza
Publikováno v:
Journal of medical genetics.
Pathogenic germline variants in the protection of telomeres 1 gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64c3cf9fc9ad536181698f23c89b8e0c
https://pubmed.ncbi.nlm.nih.gov/36539277
https://pubmed.ncbi.nlm.nih.gov/36539277
Autor:
Irving Simonin-Wilmer, Raul Ossio, Emmett Leddin, Mark Harland, Karen A. Pooley, Mauricio Gerardo Martil de la Garza, Sofia Obolenski, James Hewinson, Chi C. Wong, Vivek Iyer, John C. Taylor, Julia A. Newton-Bishop, D. Timothy Bishop, G. Andrés Cisneros, Mark M. Iles, David J. Adams, Carla Daniela Robles-Espinoza
Pathogenic germline variants in the protection of telomeres 1 gene (POT1) have been associated with predisposition to a range of tumor types, including melanoma, glioma, leukemia and cardioangiosarcoma. We sequenced all coding exons of the POT1 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52c601b4a8c092ef8bb03f703473f143
https://doi.org/10.1101/2022.05.16.22274971
https://doi.org/10.1101/2022.05.16.22274971
Autor:
Pablo Castro-Hartmann, Shengjiang Tan, Penny Wright, David J. Adams, Alexandre Faille, Christine Hilcenko, Norberto Escudero-Urquijo, Pekka Jaako, Alan J. Warren, Chi C. Wong
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1 (both mutated in the leukaemia predisposition disorder Shwachman-Diamond syndrome) license
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e45e8774752f2a669f538203b3da057
https://doi.org/10.1101/2021.09.06.459071
https://doi.org/10.1101/2021.09.06.459071
Autor:
Patrick Thomas, David J. Adams, Chi C. Wong, Emmanuelle Supper, Saskia S. Rudat, Vivek Iyer, Alastair Droop, Jean-François Spinella, Guy Sauvageau, Kim Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive responses. Whether tumor suppressor gene haploinsufficiency leads to such phenomena and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5880e4e9d61ba558263d4dacc9fd4d7b
https://doi.org/10.1038/s41467-021-22750-8
https://doi.org/10.1038/s41467-021-22750-8
Autor:
Julia Newton-Bishop, David Rodríguez, Louise van der Weyden, Paul W. Harms, Hélène Zattara, Timothy M. Johnson, Chi C. Wong, Paula Aguilera, James Hewinson, Víctor Quesada, Carla Daniela Robles-Espinoza, Alison B. Durham, Carlos López-Otín, Saskia S. Rudat, Susana Puig, Miriam Potrony, David J. Adams, Brigitte Bressac-de Paillerets, Christopher D.M. Fletcher, Mark J. Arends, Joan Anton Puig-Butille, Thomas Brenn, David B. Lombard, D. Timothy Bishop, Kim Wong
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Importance: The protection of telomeres 1 protein (POT1) is a critical component of the shelterin complex, a multiple-protein machine that regulates telomere length and protects telomere ends. Germline variants in POT1 have been linked to familial me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1066d242a51dec057046b6a1ae7135d8
http://hdl.handle.net/2445/157718
http://hdl.handle.net/2445/157718