Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.

Autor: Becky L Rivoire, Nathan A Groathouse, Stephen TerLouw, Kapil Dev Neupane, Chaman Ranjit, Bishwa Raj Sapkota, Saraswoti Khadge, Chhatra B Kunwar, Murdo Macdonald, Rachel Hawksworth, Min B Thapa, Deanna A Hagge, Melinda Tibbals, Carol Smith, Tina Dube, Dewei She, Mark Wolff, Eric Zhou, Mamodikoe Makhene, Robin Mason, Christine Sizemore, Patrick J Brennan

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2811 (2014)

New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trial

Externí odkaz: https://doaj.org/article/7e1eeddeb5ad4ae4898d8b0c85f7af5a

Exploratory urinary metabolomics of type 1 leprosy reactions

Autor: Oleg. A. Mayboroda, Anouk van Hooij, Rico Derks, Susan J.F. van den Eeden, Karin Dijkman, Saraswoti Khadge, Pratibha Thapa, Chhatra B. Kunwar, Deanna A. Hagge, Annemieke Geluk

Publikováno v: International Journal of Infectious Diseases, Vol 45, Iss C, Pp 46-52 (2016)

Background: Leprosy is an infectious disease caused by Mycobacterium leprae that affects the skin and nerves. Although curable with multidrug therapy, leprosy is complicated by acute inflammatory episodes called reactions, which are the major causes

Externí odkaz: https://doaj.org/article/aa8df4aad8a548ad96b84f7b10b6eb1d

Molecular basis of bile-salt- and iron-induced enterohaemorrhagic

Autor: Chhatra B, Kunwar, Sarah, Birstonas, Joseph B, McPhee, Debora, Barnett Foster

Publikováno v: Microbiology (Reading, England). 166(12)

Colonization of the gastrointestinal tract by enterohaemorrhagic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e62b89eace941f7ccab4ab1ce4d19397
https://pubmed.ncbi.nlm.nih.gov/33205745

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

Autor: Sayera Banu, Jolien J. van der Ploeg-van Schip, Yonas Bekele, Robert L. Modlin, Abraham Aseffa, Mariëlle C. Haks, Saraswoti Khadge, Annemieke Geluk, Pratibha Thapa, Chhatra B. Kunwar, Maria Tió-Coma, Milton Ozório Moraes, Jelle J. Goeman, Erik W. van Zwet, Isabela Maria Bernardes Goulart, Rosane M. B. Teles, Kidist Bobosha, Roberta Olmo Pinheiro, Deanna A. Hagge, Anouk van Hooij, Tom H. M. Ottenhoff

Publikováno v: Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics cannot identify which patients are at risk of developing reactions. This study assessed blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af90d4a2dd5456de4cddaee9298791d
https://doi.org/10.1038/s41598-019-54213-y

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M: leprae in Brazil, Ethiopia and Nepal

Autor: Kees L. M. C. Franken, Annemieke Geluk, Abraham Aseffa, Deanna A. Hagge, Kidist Bobosha, Marcia V. S. B. Martins, Geraldo M. B. Pereira, Jolien J. van der Ploeg-van Schip, Pratibha Thapa, Jemal Hussien, Saraswoti Khadge, Maria Cristina Vidal Pessolani, Sheila Tuyet Tang, Heitor de Sá Gonçalves, Maria Araci de Andrade Pontes, Ole Lund, Chhatra B. Kunwar, Yonas Bekele, Tom H. M. Ottenhoff

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 107, Iss suppl 1, Pp 112-123 (2012)
Mem�rias do Instituto Oswaldo Cruz.
Technical University of Denmark Orbit
Memórias do Instituto Oswaldo Cruz, Volume: 107 Supplement 1, Pages: 112-123, Published: DEC 2012

Silent transmission of Mycobacterium leprae, as evidenced by stable leprosy incidence rates in various countries, remains a health challenge despite the implementation of multidrug therapy worldwide. Therefore, the development of tools for the early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b9fbb78b36eceee70dd3670dac0f27
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900018&lng=en&tlng=en