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Autor:
Cheyenna Krone, Alla S. Kostyukova, Dmitri Tolkatchev, Fadel A. Samatey, Inna Krieger, Thu Ly, ChulHee Kang, Timothy W. Moural
Publikováno v:
Protein Science. 27:498-508
The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts conformation of a coiled coil which is