Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chew L, Lau"'
Autor:
Victoria M. McLeod, Mathew D. F. Chiam, Nirma D. Perera, Chew L. Lau, Wah Chin Boon, Bradley J. Turner
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling via the androgen receptor (AR), predominate in males, and have widespread actions in the perip
Externí odkaz:
https://doaj.org/article/92fd79cd0a5a4fa5aab2084315b116af
Autor:
Victoria M, McLeod, Mathew D F, Chiam, Nirma D, Perera, Chew L, Lau, Wah Chin, Boon, Bradley J, Turner
Publikováno v:
Frontiers in endocrinology. 13
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a11915f2cbb22d865f702cc03052736
https://pubmed.ncbi.nlm.nih.gov/35273564
https://pubmed.ncbi.nlm.nih.gov/35273564
Autor:
Ross D O'Shea, Chew L Lau, Natasha B Zulaziz, Francesca L Maclean, David R Nisbet, Malcolm K Horne, Philip M Beart
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK) cause stellation of
Externí odkaz:
https://doaj.org/article/445f12325afc48fc9c7ed1903f88c828
Publikováno v:
genesis. 58
The Cre-loxP strategy for tissue selective gene deletion has become a widely employed tool in neuroscience research. The validity of these models is largely underpinned by the temporal and spatial selectivity of recombinase expression under the promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f7f13adeb660d432ed138be43fc024
https://doi.org/10.1002/dvg.23390
https://doi.org/10.1002/dvg.23390
Autor:
Thusitha Rupasinghe, Wah Chin Boon, Victoria M. McLeod, Bradley J. Turner, Mathew D. F. Chiam, Chew L. Lau
Publikováno v:
Endocrinology. 161(9)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons which shows sexual dimorphism in its incidence, age of onset, and progression rate. All steroid hormones, including androgens, estrogens, and progestogens, hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86a955183131f77e91148d720bd0375
https://pubmed.ncbi.nlm.nih.gov/32621747
https://pubmed.ncbi.nlm.nih.gov/32621747
Autor:
Sam Ozergun, Philip M Beart, Cecilia Cederfur, Ross D O'Shea, Jason J. Wang, Kevin E. Healy, Chew L. Lau, Doris Tomas, David R. Nisbet, Francesca L Maclean, Frederick R. Walker, Malcolm K. Horne
Publikováno v:
Journal of materials chemistry. B. 5(22)
Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibits functional repair and recovery if persistent. Many biomaterial systems have been investigated for neural tissue engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0eb9bf486a3700cc92db7df4ce0733
https://pubmed.ncbi.nlm.nih.gov/32264140
https://pubmed.ncbi.nlm.nih.gov/32264140
Autor:
Philip M Beart, Chew L. Lau, Mathew D. F. Chiam, Samantha K. Barton, Bradley J. Turner, Hakan Muyderman, Doris Tomas
Publikováno v:
Neurochemical research. 45(6)
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34516e853405492b24f0876a58b234dc
https://pubmed.ncbi.nlm.nih.gov/32410044
https://pubmed.ncbi.nlm.nih.gov/32410044
Autor:
Malcolm K. Horne, Philip M Beart, Nirma D Perera, Yea Seul Shin, Chew L. Lau, Rebecca K. Sheean, Bradley J. Turner
Publikováno v:
Autophagy
Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e52e9f8b341d59cd1a07f8ecfa1debe
http://europepmc.org/articles/PMC5915012
http://europepmc.org/articles/PMC5915012
Autor:
Victoria M. McLeod, Thusitha Rupasinghe, Bradley J. Turner, Ute Roessner, Chew L. Lau, Elvan Djouma, Mathew D. F. Chiam, Wah C. Boon
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are mediated by androgen recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76de5dbd66fa98a4405383e24f7c489
https://doi.org/10.1111/bph.14657
https://doi.org/10.1111/bph.14657
Autor:
James G. Ryall, Yea Seul Shin, Phillip Nagley, Chew L. Lau, Joanne M. Britto, Philip M Beart, Rodney J. Devenish
Publikováno v:
Journal of neurochemistry. 149(2)
Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuronal mitophagy by disruption of mitochondrial energy metabolism in primary neurons. Mitophagy was examined in cultured mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33062bcd1d3fee2a32ba274b67442ba0
https://pubmed.ncbi.nlm.nih.gov/30664245
https://pubmed.ncbi.nlm.nih.gov/30664245