Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV 1.5 Channel in Cardiac MyocytesNovelty and Significance

Autor: Eichel, Catherine A., Beuriot, Adeline, Chevalier, Morgan Y.E., Rougier, Jean-Sébastien, Louault, Florent, Dilanian, Gilles, Amour, Julien, Coulombe, Alain, Abriel, Hugues, Hatem, Stéphane N., Balse, Elise

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2016, 119 (4), pp.544-556. ⟨10.1161/CIRCRESAHA.116.309254⟩
Circulation Research, 2016, 119 (4), pp.544-556. ⟨10.1161/CIRCRESAHA.116.309254⟩

International audience; Rationale: Mechanisms underlying membrane protein localization are crucial in the proper function of cardiac myocytes. The main cardiac sodium channel, NaV1.5, carries the sodium current (INa) that provides a rapid depolarizin

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https://hal.sorbonne-universite.fr/hal-01528973/file/Eichel_2016_Lateral.pdf