Výsledky vyhledávání - "Cheuk Wun, Li"

Akademický článek

Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Autor: Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C. Faustino, Kookjoo Kim, Oliver B. Clarke, Hanxi Hou, Yaron Tomer

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Autoimmune polyglandular syndrome type 3 variant (APS3v) refers to an autoimmune condition in which both type 1 diabetes (T1D) and autoimmune thyroiditis (AITD) develop in the same individual. HLA-DR3 confers the strongest susceptibility to APS3v. Pr

Externí odkaz: https://doaj.org/article/1450f3e9884b4371b2b2979151dcc19c

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GENETICS AND EPIGENETICS OF AUTOIMMUNE THYROID DISEASES: TRANSLATIONAL IMPLICATIONS

Autor: Hanna J. Lee, Mihaela Stefan–Lifshitz, Cheuk Wun Li, Yaron Tomer

Publikováno v: Best Pract Res Clin Endocrinol Metab

Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are prevalent autoimmune disorders, representing opposite ends of the clinical spectrum of autoimmune thyroid diseases (AITD). The pathogenesis involves a complex interplay between environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f38f3418c91f71620e280c0eefd4f54
https://europepmc.org/articles/PMC9550878/

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OR19-5 Dissecting Thyroidal Pathways Activated by PD-L1 Blockade Identifies New Mechanisms for Thyroiditis Triggered by Immune Checkpoint Inhibitors

Autor: Hanxi Hou, Cheuk Wun Li, Yaron Tomer, Zhengzi Yi, Weijia Zhang, Mihaela Stefan Lifshitz

Publikováno v: Journal of the Endocrine Society. 6:A802-A802

Programmed death-ligand 1 (PD-L1) is a strong immunosuppressor that inhibits T-cell activation by binding to its receptor (PD-1) on T-cells. Blocking the PD-L1/PD-1 interaction by monoclonal antibodies (mAbs) is an effective therapy for several cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e12a0eb30ee234a562641265e077d44
https://doi.org/10.1210/jendso/bvac150.1660

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Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci

Autor: Yaron Tomer, Cheuk Wun Li, Zhengzi Yi, Mihaela Stefan-Lifshitz, Weijia Zhang, Erlinda Concepcion, Anitha D. Jayaprakash, Ravi Sachidanandam

Publikováno v: J Clin Endocrinol Metab

Context Genetic risk factors play a major role in the pathoetiology of autoimmune thyroid diseases (AITD). So far, only common risk variants have been identified in AITD susceptibility genes. Recently, rare genetic variants have emerged as important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a3becedd2a31595272c79655279ab4
https://europepmc.org/articles/PMC8530708/

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A Novel Mouse Model of Autoimmune Thyroiditis Induced by Immunization with Adenovirus Containing Full-Length Thyroglobulin cDNA: Implications to Genetic Studies of Thyroid Autoimmunity

Autor: Kookjoo Kim, Larissa C. Faustino, Cheuk Wun Li, Mihaela Stefan-Lifshitz, Oliver B. Clarke, Yaron Tomer

Publikováno v: Thyroid

Background: Thyroglobulin (TG) is a key autoantigen in autoimmune thyroid diseases (AITD). Several single nucleotide polymorphisms (SNPs) in the TG locus were shown to be strongly associated with disease susceptibility in both humans and mice, and au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a45c1a508da4be1688f5a225666b8f
https://pubmed.ncbi.nlm.nih.gov/32228171

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CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation

Autor: Randall P. Owen, Cheuk Wun Li, Angela Lombardi, William B. Inabnet, Mihaela Stefan, Erlinda Concepcion, Hanna J. Lee, Yaron Tomer

Publikováno v: Endocrinology. 158:410-418

CD40, a tumor necrosis factor receptor, is a major immune-modulating susceptibility gene for Graves disease (GD) as well as for a variety of other autoimmune diseases. Its broad association with autoimmunity underscores its paramount role in the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01e4c7f87fcd4a79f7c0e0704b339ba
https://doi.org/10.1210/en.2016-1609

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Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves' disease

Autor: Cheuk Wun Li, Yaron Tomer, Erlinda Concepcion, Roman Osman, Francesca Menconi

Publikováno v: J Autoimmun

We have previously identified a signature HLA-DR3 pocket variant, designated HLA-DRβ1-Arg74 that confers a high risk for Graves’ Disease (GD). In view of the key role of HLA-DRβ1-Arg74 in triggering GD we hypothesized that thyroid-stimulating hor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3459d3e26b174ed17bed14dcf18b9c
https://pubmed.ncbi.nlm.nih.gov/31980336

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Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis

Autor: Mihaly Mezei, Francesca Menconi, Yaron Tomer, Roman Osman, Eric M. Jacobson, David B. Kastrinsky, Michael Ohlmeyer, Cheuk Wun Li, Erlinda Concepcion, Chella S. David

Publikováno v: Journal of Biological Chemistry. 291:4079-4090

We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a290fd283f9f9d18f03890e76ea5cc1e
https://doi.org/10.1074/jbc.m115.694687

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