Singapore Undiagnosed Disease Program: Genomic Analysis aids Diagnosis and Clinical Management

Autor: Breana Cham, Jiin Ying Lim, Wendy K.M. Liew, Yuen-Ming Tan, Jyn-Ling Kuan, Bruno Reversades, Raman Sethi, Alvin Yu Jin Ng, Nathalie Escande-Beillard, Alexander Lezhava, Sumanty Tohari, Heming Wei, Arun George Devasia, Deepa Subramanian, Sylvia Kam, Woei Kang Liew, Min Xie, Kanika Jain, Saumya Shekhar Jamuar, Hai-Yang Law, Ee Shien Tan, Nilesh R. Tawari, Swati Tomar, Ene-Choo Tan, Ivy Ng, Carine Bonnard, Grace Lin, Angeline Lai, Chew Yin Jasmine Goh, Perumal Dharuman, Poh San Lai, Arthi Shanmugasundaram, Huilin Chin, Neha Singh Bhatia, Denise L.M. Goh, Maggie Brett, Célia Bosso-Lefèvre, Grace K. Tan, Teck Wah Ting, Roger Foo, Sarah B Ng, Cheuk Ka Tong, Byrappa Venkatesh, Zenia Tiang

Publikováno v: Archives of Disease in Childhood. 106:31-37

ObjectiveUse next-generation sequencing (NGS) technology to improve our diagnostic yield in patients with suspected genetic disorders in the Asian setting.DesignA diagnostic study conducted between 2014 and 2019 (and ongoing) under the Singapore Undi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bba7015302a03439efc4b46889a6c9
https://doi.org/10.1136/archdischild-2020-319180

Primary cilia are required in a unique subpopulation of neural progenitors

Autor: Jugal K. Shah, Kirsten Obernier, Arturo Alvarez-Buylla, Cristina D. Guinto, Cheuk Ka Tong, Young-Goo Han

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 34

The apical domain of embryonic (radial glia) and adult (B1 cells) neural stem cells (NSCs) contains a primary cilium. This organelle has been suggested to function as an antenna for the detection of morphogens or growth factors. In particular, primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f207e85033e3101d881e64b4174fb53
https://escholarship.org/uc/item/4998x5g3

Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair

Autor: Kirsten Obernier, Cheuk Ka Tong, Arturo Alvarez-Buylla

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 8 (2014)

Neural stem cells (NSCs) in the walls of the lateral ventricles continue to produce new neurons and oligodendrocytes throughout life. The identification of NSCs, long-range neuronal migration, and the integration of new neurons into fully formed matu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7602536e514100d30caffd5465238d
https://pubmed.ncbi.nlm.nih.gov/24987325

Axons take a dive

Autor: Cheuk Ka Tong, Arantxa Cebrián-Silla, Eric J. Huang, José Manuel García-Verdugo, Mercedes F. Paredes, Arturo Alvarez-Buylla

Publikováno v: Neurogenesis (Austin, Tex.), vol 1, iss 1
Tong, CK; Cebrián-Silla, A; Paredes, MF; Huang, EJ; García-Verdugo, JM; & Alvarez-Buylla, A. (2014). Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.. Neurogenesis (Austin, Tex.), 1(1). doi: 10.4161/neur.29341. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1hs0h6wx

In the walls of the lateral ventricles of the adult mammalian brain, neural stem cells (NSCs) and ependymal (E1) cells share the apical surface of the ventricular-subventricular zone (V-SVZ). In a recent article, we show that supraependymal serotoner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ddbd14207a8707b1a778676e151ae8
https://doi.org/10.4161/neur.29341

Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair.

Autor: Obernier, Kirsten, Cheuk Ka Tong, Alvarez-Buylla, Arturo

Publikováno v: Frontiers in Neuroscience; Jun2014, Vol. 8, p1-6, 6p