Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chetna Sharon"'
Autor:
Pavani Pingali, Y. Jeffrey Wu, Rio Boothello, Chetna Sharon, Howard Li, Srinivas Sistla, Nehru Viji Sankaranarayanan, Umesh R. Desai, Anh T. Le, Robert C. Doebele, Leslie L. Muldoon, Bhaumik B. Patel, Alexander Neuwelt
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 348-359 (2021)
High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's a
Externí odkaz:
https://doaj.org/article/a566ac75bb6b41de905d39f86be028a1
Autor:
Alan H. M. Wong, Aidan C. A. Tomlinson, Dongxia Zhou, Malathy Satkunarajah, Kevin Chen, Chetna Sharon, Marc Desforges, Pierre J. Talbot, James M. Rini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analy
Externí odkaz:
https://doaj.org/article/f6588e45349a4419aa4c7ce1d24b3317
Autor:
Shravan Morla, Ongolu Ravikumar, Connor O’Hara, Rio Boothello, Alberto Vera, Elsamani I. Abdelfadiel, Rawan Fayyad, Daniel K. Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B. Patel, Umesh R. Desai
Publikováno v:
Journal of Medicinal Chemistry. 66:1321-1338
Autor:
Bhaumik B. Patel, Umesh R. Desai, H. Robert Lippman, Donald F. Brophy, Shravan Morla, Elsamani I. Abdelfadiel, Chetna Sharon, Nirmita J. Patel, Rio S. Boothello
The 16 page composite document outlines supplemental methods as well as Figures. Fig S1: a- In vivo tumor formation assay with subcutaneous injections of (2,000) Dual hi HT-29 cells show high tumor forming efficiency of Dual hi cells compared to unso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb7fdafd2a3267268ec88591383c8dd
https://doi.org/10.1158/1535-7163.22509093.v1
https://doi.org/10.1158/1535-7163.22509093.v1
Autor:
Rio S. Boothello, Nehru Viji Sankaranarayanan, Jyothi C. Sistla, Balaji Nagarajan, Chetna Sharon, John E. Chittum, Rabiya Y. Niyaz, Swarnali Roy, Aditi Nandi, Connor P. O'Hara, Rahaman Navaz Gangji, Daniel K. Afosah, Ravikumar Ongolu, Bhaumik B. Patel, Umesh R. Desai
Publikováno v:
Angewandte Chemie (International ed. in English). 61(49)
The insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational, thermodynamic, and cellular imaging studies reveal that activation of IGF-1R by its cognate ligand
Autor:
Umesh R. Desai, Anh T. Le, Howard Li, Leslie L. Muldoon, Chetna Sharon, Bhaumik B. Patel, Srinivas Sistla, Nehru Viji Sankaranarayanan, Y. Jeffrey Wu, Pavani Pingali, Alexander J. Neuwelt, Rio S. Boothello, Robert C. Doebele
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 348-359 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's a
Autor:
Shoja Hajira, Chetna Sharon, Daniel RodriguezAgudo, Rio Boothelllo, Glenn Kellogg, Gregorio Gil, William Pandak, Bhaumik B. Patel
Publikováno v:
Cancer Research. 83:6259-6259
Background: Treatment of colorectal cancer (CRC) presents a major challenge due to chemotherapeutic resistance and recurrence, which are attributed to the presence of cancer stem cells (CSCs). Cholesterol metabolism is a critical regulator of CSCs. L
Autor:
Chetna Sharon
Publikováno v:
Nanotechnology in the Defense Industry
Autor:
Ravi C. Kalathur, Shravan Morla, Umesh R. Desai, Bhaumik B. Patel, Alhumaidi B Alabbas, Chetna Sharon, Jyothi C. Sistla
Publikováno v:
Carbohydrate Polymers. 205:385-391
Heparanase, an endo-β-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains and plays important roles in cellular growth and metastasis. Heparanase assays reported to-date are labor intensive, complex and/or expe
Autor:
Donald F. Brophy, Elsamani I. Abdelfadiel, H. Robert Lippman, Bhaumik B. Patel, Shravan Morla, Chetna Sharon, Nirmita J. Patel, Umesh R. Desai, Rio S. Boothello
Publikováno v:
Molecular Cancer Therapeutics. 18:51-61
Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated glycosaminoglycan (GAG) chains are known to play a critical role in the regulation of stem c