Výsledky vyhledávání - "Chetna Dhembla"

STAT3 inhibition mediated upregulation of multiple immune response pathways in dengue infection

Autor: Shikha Srivastava, Nidhi Chaudhary, Chetna Dhembla, Monica Sundd, Sunny Gupta, Ashok Kumar Patel

Publikováno v: Virology. 578

Dengue infection is a world-wide public health threat infecting millions of people annually. Till date no specific antiviral or vaccine is available against dengue virus. Recent evidence indicates that targeting host STAT3 could prove to be an effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9024526f9243081b2acf3cd708bd480b
https://pubmed.ncbi.nlm.nih.gov/36473280

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Lipoate protein ligase B primarily recognizes the C

Autor: Chetna, Dhembla, Usha, Yadav, Suman, Kundu, Monica, Sundd

Publikováno v: The Journal of biological chemistry. 298(8)

Lipoic acid is a sulfur-containing cofactor indispensable for the function of several metabolic enzymes. In microorganisms, lipoic acid can be salvaged from the surroundings by lipoate protein ligase A (LplA), an ATP-dependent enzyme. Alternatively,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c89e5ecaea3ca1353416e0adeccb64b3
https://pubmed.ncbi.nlm.nih.gov/35764173

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Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate, and weakly binds the acyl carrier protein

Autor: Chetna Dhembla, Usha Yadav, Suman Kundu, Monica Sundd

Lipoic acid is a sulfur containing cofactor, indispensable for the function of several metabolic enzymes. In microorganisms, lipoic acid can be salvaged from the surroundings by Lipoate protein ligase A (LplA), an ATP-dependent enzyme. Alternatively,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce98b35c15f5621ea837c04851df154d
https://doi.org/10.1101/2022.01.03.474776

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Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein

Autor: Chetna Dhembla, Usha Yadav, Suman Kundu, Monica Sundd

Publikováno v: Journal of Biological Chemistry. 298:102203

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b70f0fcbd2324b2f0356b56b541eb4a
https://doi.org/10.1016/j.jbc.2022.102203

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Suramin, penciclovir, and anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2

Autor: Suman Kundu, H. K. Das, Manisha Saini, Varnita Anand, Sanjay Kumar Dey, A. Sai Rajesh, Chetna Dhembla, Shruti Bhatt

COVID-19, for which no confirmed therapeutic agents are available, has claimed over 48,14,000 lives globally. A feasible and quicker method to resolve this problem may be ��drug repositioning��. We investigated selected FDA and WHO-EML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a699523ce88c77108513f74754133a1

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An overview of the fatty acid biosynthesis in the protozoan parasite Leishmania and its relevance as a drug target against leishmaniasis

Autor: Monica Sundd, Chetna Dhembla, Richa Arya, Ravindra D. Makde, Suman Kundu

Publikováno v: Molecular and Biochemical Parasitology. 246:111416

Leishmaniasis is one of the fast-growing parasitic diseases worldwide. The treatment of this fatal disease presents a daunting challenge because of its adverse effects, necessity for long-term treatment regime, unavailability of functional drugs, eme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e78a2378fecfada1177df1bf03800f
https://doi.org/10.1016/j.molbiopara.2021.111416

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Differential expression of structural and functional proteins during bean common mosaic virus-host plant interaction

Autor: Sunil Kumar, Ashok Kumar Patel, Monica Sundd, Puttaswamy Hariprasad, Chetna Dhembla

Publikováno v: Microbial Pathogenesis. 138:103812

Bean common mosaic virus (BCMV), the most common seed-borne pathogen in Phaseolus vulgaris L. is known to cause severe loss in productivity across the globe. In the present study, proteomic analyses were performed for leaf samples from control (healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930e8434cef34dba6f4bf6743c35faeb
https://doi.org/10.1016/j.micpath.2019.103812

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A conformational switch from a closed apo- to an open holo-form equips the acyl carrier protein for acyl chain accommodation

Autor: Richa Arya, Monica Sundd, Ashok Kumar Patel, Biplab Ghosh, Ravi Kant Pal, Chetna Dhembla, Bhaskar Sharma, Ravindra D. Makde, Suman Kundu

Publikováno v: Biochimica et biophysica acta. Proteins and proteomics. 1867(3)

Acyl carrier proteins (ACPs) play crucial roles in the biosynthesis of fatty acids, non-ribosomal polypeptides and polyketides. The three-dimensional NMR structure of Leishmania major holo-LmACP, belonging to the type II pathway, has been reported pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7459332e874eb160e35d32873653070e
https://pubmed.ncbi.nlm.nih.gov/30543875

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