Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Chetan Seshadri"'
Autor:
Eva Morgun, Jennifer Zhu, Sultan Almunif, Sharan Bobbala, Melissa S Aguilar, Junzhong Wang, Kathleen Conner, Yongyong Cui, Liang Cao, Chetan Seshadri, Evan A Scott, Chyung-Ru Wang
Publikováno v:
eLife, Vol 12 (2023)
Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been underexplored, and the characteristics
Externí odkaz:
https://doaj.org/article/6b58467588cc497ca1e3645a884385c2
Autor:
Leela R.L. Davies, Malisa T. Smith, Deniz Cizmeci, Stephanie Fischinger, Jessica Shih-Lu Lee, Lenette L. Lu, Erik D. Layton, Alison D. Grant, Katherine Fielding, Catherine M. Stein, W. Henry Boom, Thomas R. Hawn, Sarah M. Fortune, Robert S. Wallis, Gavin J. Churchyard, Galit Alter, Chetan Seshadri
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104678- (2023)
Summary: Background: The prevalence of tuberculosis among men who work in the gold mines of South Africa is among the highest in the world, but a fraction of miners demonstrate consistently negative results upon tuberculin skin test (TST) and IFN-γ
Externí odkaz:
https://doaj.org/article/0c58ca4c3fba49d19ebee7d80aaf7eba
Autor:
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid antigens
Externí odkaz:
https://doaj.org/article/5ffbba8ac40b4631bfdd4ca36548cb97
Autor:
Charlotte A. James, Krystle K. Q. Yu, Koshlan Mayer-Blackwell, Andrew Fiore-Gartland, Malisa T. Smith, Erik D. Layton, John L. Johnson, Willem A. Hanekom, Thomas J. Scriba, Chetan Seshadri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mycobacterium bovis bacille Calmette-Guérin (BCG) has been used for 100 years and prevents disseminated tuberculosis and death in young children. However, it shows only partial efficacy against pulmonary tuberculosis (TB) in adults, so new vaccines
Externí odkaz:
https://doaj.org/article/40487468caea45fc8383a847ed127c0d
Autor:
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W.Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H.M. Ottenhoff, Sara Suliman, D.Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103839- (2022)
Summary: Background: Non-protein antigen classes can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1. Such T cells, referred to as donor unrestricted T (DURT) cells, typically express st
Externí odkaz:
https://doaj.org/article/bd74aa9198634f0bb4c2132383ad064c
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/df52ceba03f540bf9fa7b85d18b26eee
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010018 (2021)
T cell receptors (TCRs) encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection. In addition to peptide antigens bound to highly polymorphic MHC molecules, T cells have also evo
Externí odkaz:
https://doaj.org/article/0e27a587a4b14fdc8017bcdd89b1fada
Autor:
Krystle K.Q. Yu, Stephanie Fischinger, Malisa T. Smith, Caroline Atyeo, Deniz Cizmeci, Caitlin R. Wolf, Erik D. Layton, Jennifer K. Logue, Melissa S. Aguilar, Kiel Shuey, Carolin Loos, Jingyou Yu, Nicholas Franko, Robert Y. Choi, Anna Wald, Dan H. Barouch, David M. Koelle, Douglas Lauffenburger, Helen Y. Chu, Galit Alter, Chetan Seshadri
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Comorbid medical illnesses, such as obesity and diabetes, are associated with more severe COVID-19, hospitalization, and death. However, the role of the immune system in mediating these clinical outcomes has not been determined. We used multiparamete
Externí odkaz:
https://doaj.org/article/b5959002267547a3b33b4f8d69ee17df
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Tuberculosis (TB) is one of the most potent infectious diseases in the world, causing more deaths than any other single infectious agent. TB infection is caused by inhalation of Mycobacterium tuberculosis (Mtb) and subsequent phagocytosis and migrati
Externí odkaz:
https://doaj.org/article/762309cca6a54676b2bbbe45d97da9c3
Autor:
Charlotte A. James, Chetan Seshadri
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specifi
Externí odkaz:
https://doaj.org/article/3867b1a88f5e47b8921162752f7d54c3