Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Chetan Poudel"'
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into
Externí odkaz:
https://doaj.org/article/9694c15ea6ff49a7afe36d07b4947267
Autor:
Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Shankland
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cel
Externí odkaz:
https://doaj.org/article/6f35f7a0c54e416aa558e94eded1b8d9
Publikováno v:
Biosensors, Vol 12, Iss 7, p 459 (2022)
Taking the life of nearly 10 million people annually, cancer has become one of the major causes of mortality worldwide and a hot topic for researchers to find innovative approaches to demystify the disease and drug development. Having its root lying
Externí odkaz:
https://doaj.org/article/6025d5af391f4d2f9afec8fcfb9ec157
Autor:
Chaolie Huang, Sara Wagner-Valladolid, Amberley D Stephens, Raimund Jung, Chetan Poudel, Tessa Sinnige, Marie C Lechler, Nicole Schlörit, Meng Lu, Romain F Laine, Claire H Michel, Michele Vendruscolo, Clemens F Kaminski, Gabriele S Kaminski Schierle, Della C David
Publikováno v:
eLife, Vol 8 (2019)
Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, spec
Externí odkaz:
https://doaj.org/article/d304ea99735c4d8ea67842213713ac7f
Publikováno v:
Annual Review of Analytical Chemistry. 16
In recent years, there has been a revived appreciation for the importance of spatial context and morphological phenotypes for both understanding disease progression and guiding treatment decisions. Compared with conventional 2D histopathology, which
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Autor:
Christopher M. Dobson, Samuel T. Dada, Maarten C. Hardenberg, Elizabeth A Robinson, Monika Fuxreiter, Sam Casford, Gabriele S. Kaminski Schierle, Clemens F Kaminksi, Tessa Sinnige, Michele Vendruscolo, Ellen A. A. Nollen, Chetan Poudel
Publikováno v:
Journal of Molecular Cell Biology, 13(4), 282. Oxford University Press
J Mol Cell Biol
Journal of Molecular Cell Biology, 13(4), 282-294. Oxford University Press
J Mol Cell Biol
Journal of Molecular Cell Biology, 13(4), 282-294. Oxford University Press
Misfolded α-synuclein is a major component of Lewy bodies, which are a hallmark of Parkinson’s disease. A large body of evidence shows that α-synuclein can self-assemble into amyloid fibrils, but the relationship between amyloid formation and Lew
Publikováno v:
Journal of microscopy. 287(3)
Fluorescence lifetime imaging (FLIM) allows the quantification of sub-cellular processes in situ, in living cells. A number of approaches have been developed to extract the lifetime from time-domain FLIM data, but they are often limited in terms of s
Autor:
Suil Collins, Liisa van Vliet, Fabrice Gielen, Matej Janeček, Sara Wagner Valladolid, Chetan Poudel, Giuliana Fusco, Alfonso De Simone, Claire Michel, Clemens Kaminski, David Spring, Florian Hollfelder, Gabriele S Kaminski Schierle
Inhibiting the aggregation of amyloid β (1-42) is a promising strategy for the development of disease-modifying Alzheimer’s disease therapeutics. To date, however, no sufficiently efficacious inhibitors have been identified, despite the best effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9d19a9a73b84853d984a10f3c81297
https://doi.org/10.21203/rs.3.rs-1478521/v1
https://doi.org/10.21203/rs.3.rs-1478521/v1
Autor:
Melissa T. Adams, Thuong Ho, Sophia M. Sdao, Hannah R. Foster, Ji-Hyeon Lee, Barak Blum, Matthew J. Merrins, Elizabeth R. De Leon, Chetan Poudel, Sushil G. Rane
Hallmarks of mature β cells are restricted proliferation and a highly energetic secretory state. Paradoxically, cyclin-dependent kinase 2 (CDK2) is synthesized throughout adulthood, its cytosolic localization raising the likelihood of cell cycle-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8108f150c2ef11682c0f41ad87e3f530
Autor:
Chetan Poudel
Publikováno v:
Chetan Poudel
This thesis presents the development of fluorescence lifetime imaging microscopy (FLIM) methodologies to advance biological understanding of neurodegeneration and stem cell differentiation. Two FLIM technologies enabling faster FLIM acquisition were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bca948d55e205dc4c88f11352ac968