Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors

Autor: Sarah Grimwood, Brian D. Harvey, Dmitri Volfson, Chester J. Siok, Mihály Hajós, Christopher L. Shaffer, Tamás Kiss

Publikováno v: Neuropharmacology. 75:19-30

The Group I metabotropic glutamate receptor subtype 5 (mGluR5) is widely distributed in the brain with dense expression in the cerebral cortex, hippocampus, and basal ganglia. These receptors have been implicated in psychiatric and neurological disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace85962e6d6fb1c90d6539513174fc2
https://doi.org/10.1016/j.neuropharm.2013.06.020

Modulation of Hippocampal Theta Oscillation by Histamine H3 Receptors

Autor: Shaonim Li, Chester J. Siok, Mihály Hajós, William E. Hoffmann, Bernat Kocsis

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 324:391-398

Preclinical findings demonstrate procognitive actions of histamine 3 (H3) receptor antagonists/inverse agonists. Since a prominent role of neuronal network oscillations of the hippocampus, such as theta band oscillation, has been recognized in numero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34566a91c44f68f455d4d0179df09d37
https://doi.org/10.1124/jpet.107.130070

Defining the brain circuits involved in psychiatric disorders: IMI-NEWMEDS

Autor: Maurizio Riga, Thérèse M. Jay, Robert Becker, Anushree Tripathi, Hamdy Shaban, Michael Spedding, Noemí Santana, Michael Didriksen, Esther Schenker, Samir Takkilah, Claude Sebban, Pau Celada, Jean Mariani, Andreas Meyer-Lindenberg, Bill P. Godsil, Noemi Jurado, Natalia Gass, Adam J. Schwarz, Eva Troyano-Rodriguez, Anna Castañé, Mercedes Núñez, Francesc Artigas, Wolfgang Weber-Fahr, Mark D. Tricklebank, Mihaily Hajos, Chester J. Siok, Jesper F. Bastlund, Hanna E. van den Munkhof, Celine Risterucci, Laia Lladó-Pelfort, Zoë A. Hughes, Karsten Wicke, Philippe Faure, Alexander Sartorius

Publikováno v: Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, Nature Publishing Group, 2017, 16 (1), pp.1-2. ⟨10.1038/nrd.2016.205⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Nature Reviews Drug Discovery, 2017, 16 (1), pp.1-2. ⟨10.1038/nrd.2016.205⟩

Despite the vast amount of research on schizophrenia and depression in the past two decades, there have been few innovative drugs to treat these disorders. Precompetitive research collaborations between companies and academic groups can help tackle t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ae035a2593867e1bc2a09418386a5a
https://doi.org/10.1038/nrd.2016.205

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation

Autor: Kevin Atchison, Chester J. Siok, David Riddell, Mihály Hajós, Tamás Kiss, Eva Hajos-Korcsok, Elena Morozova, Charles E. Nolan

Publikováno v: Frontiers in Pharmacology, Vol 4 (2013)
Frontiers in Pharmacology

Neurological and psychiatric disorders are frequently associated with disruption of various cognitive functions, but development of effective drug treatments for these conditions has proven challenging. One of the main obstacles is the poor predictiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eb78f39400dd242206a7d4ce00c88a
https://doi.org/10.3389/fphar.2013.00072

P4‐197: A selective ORL1 antagonist enhances hippocampal function and reverses pharmacologically induced cognitive deficits in rodents

Autor: Michelle Vanase-Frawley, Michael Aaron Brodney, Robin Roof, Faith Prior, Laura McDowell, Allen J. Duplantier, Rouba Kozak, Julie Cianfrogna, Patricia A. Seymour, Dina McGinnis, Chester J. Siok, Cheng Chang, Louis Leung, Claire Leurent, Mihály Hajós, Rathna Iyer

Publikováno v: Alzheimer's & Dementia. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9004b8a9274e5bb126af30de53b93dd7
https://doi.org/10.1016/j.jalz.2011.05.2220