Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chester E. Markwalter"'
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019)
Abstract Background “Nanomedicine” is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While “translation”
Externí odkaz:
https://doaj.org/article/a14b0588afc243799b274d6dc23acabd
Autor:
Ke Chen, Kurt D. Ristroph, Jian Li, Ava N. Hejazi, Chester E. Markwalter, Robert K. Prud'homme, Robert F. Pagels, Jiping Wang
Publikováno v:
Journal of Controlled Release. 334:11-20
Peptide and protein therapeutics generally exhibit high potency and specificity and are increasingly important segments of the pharmaceutical market. However, their clinical applications are limited by rapid clearance and poor membrane permeability.
Autor:
Robert K. Prud'homme, István Pelczer, Michael H. Hecht, Pablo G. Debenedetti, Chester E. Markwalter, Shlomo Zarzhitsky, Betul Uralcan
Publikováno v:
ACS nano. 14(12)
The dosing of peptide and protein therapeutics is complicated by rapid clearance from the blood pool and poor cellular membrane permeability. Encapsulation into nanocarriers such as liposomes or polymersomes has long been explored to overcome these l
Autor:
Keming Zhu, Neil A. Strotman, Yi Hsiao, Martin D. Eastgate, Carolyn S. Wei, Maxime Soumeillant, Chester E. Markwalter
Publikováno v:
The Journal of Organic Chemistry. 84:4653-4660
Unusual Pd deactivation and inhibition pathways were observed in a C-N coupling system. Irreversible catalyst deactivation involved C-H insertion of Pd into BippyPhos leading to an off-cycle palladaphosphacyclobutene. Product inhibition led to deacti
Autor:
Akiva G. R. Gordon, Robert F. Pagels, Chester E. Markwalter, Alexandra L. Thompson, Ava N. Hejazi, Robert K. Prud'homme
Publikováno v:
The AAPS journal. 22(2)
The encapsulation of water-soluble therapeutics and biologics into nanocarriers to produce novel therapeutics has been envisioned for decades, but clinical translation has been hampered by complex synthesis strategies. The methods that have been deve
Autor:
Michael Lawler, Richard J. Fox, Keming Zhu, Chester E. Markwalter, Jacob Albrecht, Martin D. Eastgate, Payack Joseph Francis
Publikováno v:
Organic Process Research & Development. 21:754-762
The development and optimization of two scalable routes to N-methyl-3-bromo-5-methyl pyrazole is described. The initial Sandmeyer route entailed a three-step sequence from crotonitrile and methyl hydrazine, proceeding through the 3-amino pyrazole int
Publikováno v:
Protein engineering, designselection : PEDS. 32(10)
The tachykinin 2 receptor (NK2R) plays critical roles in gastrointestinal, respiratory and mental disorders and is a well-recognized target for therapeutic intervention. To date, therapeutics targeting NK2R have failed to meet regulatory agency appro
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019)
Journal of Translational Medicine
Journal of Translational Medicine
Background “Nanomedicine” is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While “translation” in drug d
Autor:
Chester E, Markwalter, Robert F, Pagels, Brian K, Wilson, Kurt D, Ristroph, Robert K, Prud'homme
Publikováno v:
Journal of visualized experiments : JoVE. (143)
The formulation of a therapeutic compound into nanoparticles (NPs) can impart unique properties. For poorly water-soluble drugs, NP formulations can improve bioavailability and modify drug distribution within the body. For hydrophilic drugs like pept
Autor:
Robert K. Prud'homme, Kurt D. Ristroph, Brian K. Wilson, Robert F. Pagels, Chester E. Markwalter
Publikováno v:
Journal of Visualized Experiments.