Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Chester A. Mathis"'
Autor:
Anton Lindberg, Emily Murrell, Junchao Tong, N. Scott Mason, Daniel Sohn, Johan Sandell, Peter Ström, Jeffrey S. Stehouwer, Brian J. Lopresti, Jenny Viklund, Samuel Svensson, Chester A. Mathis, Neil Vasdev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for
Externí odkaz:
https://doaj.org/article/565281a593e843aeae917584e9015b15
Autor:
Akiko Mizuno, Helmet Talib Karim, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Beth E. Snitz
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionSubjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying neurobiology of SCD is not completely understood. Since executive function may be a
Externí odkaz:
https://doaj.org/article/d09dae73482d4c33b4854f3ea1443d5f
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage, Vol 228, Iss , Pp 117728- (2021)
Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Du
Externí odkaz:
https://doaj.org/article/f793f64258bb45018fce502f5ace76f4
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102740- (2021)
Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer’s disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary t
Externí odkaz:
https://doaj.org/article/f466772638d948f6b49fdbd04232ca9b
Autor:
Matthew D. Zammit, Charles M. Laymon, Dana L. Tudorascu, Sigan L. Hartley, Brianna Piro‐Gambetti, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, Shahid H. Zaman, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated. Methods Adults with DS (N = 90; mean age [stand
Externí odkaz:
https://doaj.org/article/2a745a8c1cfc4547bf4fcd09aabb4a72
Autor:
Matthew D. Zammit, Charles M. Laymon, Tobey J. Betthauser, Karly A. Cody, Dana L. Tudorascu, Davneet S. Minhas, Marwan N. Sabbagh, Sterling C. Johnson, Shahid H. Zaman, Chester A. Mathis, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load (AβL) was recently developed as an alternative to standardized uptake
Externí odkaz:
https://doaj.org/article/41d1d0c1e3a0429eb5b0708fdaabd6bb
Autor:
Davneet S. Minhas, Julie C. Price, Charles M. Laymon, Carl R. Becker, William E. Klunk, Dana L. Tudorascu, Eric E. Abrahamson, Ronald L. Hamilton, Julia K. Kofler, Chester A. Mathis, Oscar L. Lopez, Milos D. Ikonomovic
Publikováno v:
NeuroImage: Clinical, Vol 19, Iss , Pp 182-189 (2018)
The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigati
Externí odkaz:
https://doaj.org/article/3c5e035567d442a8828b01b766b85844
Autor:
Chendi Cui, Aya Higashiyama, Brian J. Lopresti, Masafumi Ihara, Howard J. Aizenstein, Makoto Watanabe, Yuefang Chang, Chikage Kakuta, Zheming Yu, Chester A. Mathis, Yoshihiro Kokubo, Tetsuya Fukuda, Victor L. Villemagne, William E. Klunk, Oscar L. Lopez, Lewis H. Kuller, Yoshihiro Miyamoto, Akira Sekikawa
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1180 (2021)
The Alzheimer’s Disease Neuroimaging Initiative showed that Japanese had significantly lower brain Aβ burden than Americans among a cognitively normal population. This cross-sectional study aimed to compare vascular disease burden, Aβ burden, and
Externí odkaz:
https://doaj.org/article/d5dc05773a1443678ea811db98568c74
Autor:
David O. Okonkwo, Ross C. Puffer, Davneet S. Minhas, Sue R. Beers, Kathryn L. Edelman, Jane Sharpless, Charles M. Laymon, Brian J. Lopresti, Steven Benso, Ava M. Puccio, Sudhir Pathak, Milos D. Ikonomovic, Joseph M. Mettenburg, Walter Schneider, Chester A. Mathis, James M. Mountz
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Background: Trauma-related neurodegeneration can be difficult to differentiate from multifactorial neurodegenerative syndromes, both clinically and radiographically. We have initiated a protocol for in vivo imaging of patients with suspected TBI-rela
Externí odkaz:
https://doaj.org/article/3480f8d71f454129a8f9bd8538521328
Autor:
James M. Mountz, Charles M. Laymon, Ann D. Cohen, Zheng Zhang, Julie C. Price, Sanaa Boudhar, Eric McDade, Howard J. Aizenstein, William E. Klunk, Chester A. Mathis
Publikováno v:
NeuroImage: Clinical, Vol 9, Iss C, Pp 592-598 (2015)
Introduction: Neuritic amyloid plaques and neurofibrillary tangles, the hallmark pathologic lesions of Alzheimer's disease, are thought to develop before the symptoms of brain failure are clinically detectable. Imaging methods capable of detecting th
Externí odkaz:
https://doaj.org/article/01496eedde2c4ea8844942bc6341b004