The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndromeResearch in context

Autor: Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-McHale, Deborah Pang, Lisa Melilli, Sid O'Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Howard J. Aizenstein, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus Birn, Adam M. Brickman, Peter Bulova, Amrita Cheema, Kewei Chen, Bradley T. Christian, Isabel Clare, Lorraine Clark, Ann D. Cohen, John N. Constantino, Eric W. Doran, Anne Fagan, Eleanor Feingold, Tatiana M. Foroud, Benjamin L. Handen, Jordan Harp, Sigan L. Hartley, Rachel Henson, Lawrence Honig, Milos D. Ikonomovic, Sterling C. Johnson, Courtney Jordan, M.Ilyas Kamboh, David Keator, William E. Klunk, Julia K. Kofler, William Charles Kreisl, Sharon J. Krinsky-McHale, Patrick Lao, Ira T. Lott, Victoria Lupson, Chester A. Mathis, Davneet Singh Minhas, Neelesh Nadkarni, Sid O’Bryant, Melisa Parisi, Melissa Pettersen, Julie C. Price, Margaret Pulsifer, Michael S. Rafii, Eric Reiman, Batool Rizvi, Laurie Ryan, Frederick Schmitt, Wayne P. Silverman, Dana L. Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A. White, Michael A. Yassa, Fan Zhang

Publikováno v: EBioMedicine, Vol 110, Iss , Pp 105433- (2024)

Summary: Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this

Externí odkaz: https://doaj.org/article/7bcbc45f9a5e40b7ab0502504ef1c084

PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome

Autor: Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian

Publikováno v: NeuroImage, Vol 228, Iss , Pp 117728- (2021)

Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Du

Externí odkaz: https://doaj.org/article/f793f64258bb45018fce502f5ace76f4

Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen

Autor: Matthew D. Zammit, Charles M. Laymon, Dana L. Tudorascu, Sigan L. Hartley, Brianna Piro‐Gambetti, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, Shahid H. Zaman, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Abstract Introduction Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated. Methods Adults with DS (N = 90; mean age [stand

Externí odkaz: https://doaj.org/article/2a745a8c1cfc4547bf4fcd09aabb4a72

Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load

Autor: Davneet S. Minhas, Julie C. Price, Charles M. Laymon, Carl R. Becker, William E. Klunk, Dana L. Tudorascu, Eric E. Abrahamson, Ronald L. Hamilton, Julia K. Kofler, Chester A. Mathis, Oscar L. Lopez, Milos D. Ikonomovic

Publikováno v: NeuroImage: Clinical, Vol 19, Iss , Pp 182-189 (2018)

The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigati

Externí odkaz: https://doaj.org/article/3c5e035567d442a8828b01b766b85844

Comparing Pathological Risk Factors for Dementia between Cognitively Normal Japanese and Americans

Autor: Chendi Cui, Aya Higashiyama, Brian J. Lopresti, Masafumi Ihara, Howard J. Aizenstein, Makoto Watanabe, Yuefang Chang, Chikage Kakuta, Zheming Yu, Chester A. Mathis, Yoshihiro Kokubo, Tetsuya Fukuda, Victor L. Villemagne, William E. Klunk, Oscar L. Lopez, Lewis H. Kuller, Yoshihiro Miyamoto, Akira Sekikawa

Publikováno v: Brain Sciences, Vol 11, Iss 9, p 1180 (2021)

The Alzheimer’s Disease Neuroimaging Initiative showed that Japanese had significantly lower brain Aβ burden than Americans among a cognitively normal population. This cross-sectional study aimed to compare vascular disease burden, Aβ burden, and

Externí odkaz: https://doaj.org/article/d5dc05773a1443678ea811db98568c74