Novel therapies for cancer-induced bone pain.

Autor: Haroun R; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Gossage SJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Iseppon F; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Fudge A; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Caxaria S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Arcangeletti M; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Leese C; Department of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom., Davletov B; Department of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom., Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Sikandar S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Welsh F; AstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom., Chessell IP; AstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom., Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.

Publikováno v: Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2024 Sep 26; Vol. 16, pp. 100167. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.

Autor: Jarvis R; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Josephine Ng SF; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Nathanson AJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Cardarelli RA; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Abiraman K; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wade F; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Evans-Strong A; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Fernandez-Campa MP; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Deeb TZ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Smalley JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Jamier T; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Gurrell IK; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., McWilliams L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Kawatkar A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Conway LC; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wang Q; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Burli RW; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Brandon NJ; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Chessell IP; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Goldman AJ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Maguire JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Moss SJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA; Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1 6BT, UK. Electronic address: stephen.moss@tufts.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Mar 21; Vol. 4 (3), pp. 100957. Date of Electronic Publication: 2023 Mar 07.

Increased cyclooxygenase-2 (Cox-2) expression by macrophages in chronic but not acute nerve injury in humans and rodents

Autor: Durrenberger, PF, Facer, P, Gray, RA, Chessell, IP, Naylor, A, Bountra, C, Banati, RB, Elliot, D, Anand, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::abe97ef6d26f7bc1bebf30ff91855982
https://ora.ox.ac.uk/objects/uuid:f3a54584-3dc0-4653-a5bb-114947f042fb

A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain.

Autor: Kopruszinski CM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA., Navratilova E; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA., Swiokla J; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA., Dodick DW; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA., Chessell IP; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Porreca F; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.

Publikováno v: Cephalalgia : an international journal of headache [Cephalalgia] 2021 Mar; Vol. 41 (3), pp. 305-317. Date of Electronic Publication: 2020 Sep 26.

The Dementias Platform UK (DPUK) Data Portal.

Autor: Bauermeister S; Department of Psychiatry, University of Oxford, Oxford, UK., Orton C; Swansea University Medical School, Swansea University, Swansea, UK., Thompson S; Swansea University Medical School, Swansea University, Swansea, UK., Barker RA; Cambridge University Department of Clinical Neurosciences and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bauermeister JR; Department of Psychiatry, University of Oxford, Oxford, UK., Ben-Shlomo Y; Population Health Sciences, University of Bristol, Bristol, UK., Brayne C; Department of Public Health, University of Cambridge, Cambridge, UK., Burn D; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Campbell A; Department of Medical Genetics, University of Edinburgh, Edinburgh, UK., Calvin C; Department of Psychiatry, University of Oxford, Oxford, UK., Chandran S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Chaturvedi N; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Chêne G; Bordeaux Population Health, Université Bordeaux, Bordeaux, France., Chessell IP; Neuroscience BioPharma R&D, AstraZeneca, Cambridge, UK., Corbett A; College of Medicine and Health, University of Exeter, Exeter, UK., Davis DHJ; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Denis M; Oxford Academic Health Science Network, University of Oxford, Oxford, UK., Dufouil C; Bordeaux Population Health, Université Bordeaux, Bordeaux, France., Elliott P; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial College NIHR Biomedical Research Centre, Imperial College London, London, UK.; Health Data Research UK London at Imperial College London, London, UK., Fox N; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Hill D; King's College London, London, UK., Hofer SM; Department of Psychology, University of Victoria, Victoria, Canada., Hu MT; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Jindra C; Department of Psychiatry, University of Oxford, Oxford, UK., Kee F; Centre for Public Health, Queen's University Belfast, Belfast, UK., Kim CH; Department of Psychiatry, University of Oxford, Oxford, UK., Kim C; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea., Kivimaki M; Institute of Epidemiology and Health, University College London, London, UK., Koychev I; Department of Psychiatry, University of Oxford, Oxford, UK., Lawson RA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Linden GJ; Centre for Public Health, Queen's University Belfast, Belfast, UK., Lyons RA; Swansea University Medical School, Swansea University, Swansea, UK., Mackay C; Department of Psychiatry, University of Oxford, Oxford, UK., Matthews PM; Division of Brain Sciences and UK Dementia Research Institute, Imperial College London, London, UK., McGuiness B; Centre for Public Health, Queen's University Belfast, Belfast, UK., Middleton L; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Moody C; Medical Research Council, Swindon, UK., Moore K; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Na DL; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, UK., Ourselin S; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Paranjothy S; School of Medicine, Cardiff University, Cardiff, UK., Park KS; Institute of Health Science, Gyeongsang National University, Jinju-si, South Korea., Porteous DJ; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Richards M; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Ritchie CW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Rohrer JD; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Rossor MN; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Rowe JB; Cambridge University Department of Clinical Neurosciences and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Scahill R; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Schnier C; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Schott JM; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Seo SW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., South M; Department of Psychiatry, University of Oxford, Oxford, UK., Steptoe M; Department of Behavioural Science and Health, UCL, London, UK., Tabrizi SJ; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Tales A; Centre for Innovative Ageing, Swansea University, Swansea, UK., Tillin T; UCL Institute for Cardiovascular Science, London, UK., Timpson NJ; Population Health Sciences, University of Bristol, Bristol, UK., Toga AW; Laboratory of Neuro Imaging, USC, Los Angeles, USA., Visser PJ; VU University Medical Centre, Maastricht University, Maastricht, The Netherlands., Wade-Martins R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Wilkinson T; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Williams J; Institute of Psychological Medicine and Clinical Neurosciences, and UK Dementia Research Institute, Cardiff University, Cardiff, UK., Wong A; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Gallacher JEJ; Department of Psychiatry, University of Oxford, Oxford, UK. john.gallacher@psych.ox.ac.uk.

Publikováno v: European journal of epidemiology [Eur J Epidemiol] 2020 Jun; Vol. 35 (6), pp. 601-611. Date of Electronic Publication: 2020 Apr 23.