Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Cheryl de Valliere"'
Autor:
Carsten A. Wagner, Sebastian Mueller, Eleonora Patsenker, Katharina Baebler, Fabian Schefer, Cordelia Schuler, Gerard Dijkstra, Martin Hausmann, Senta Hutter, Céline Mamie, Isabelle Frey-Wagner, Wouter T. van Haaften, Felix Stickel, Gerhard Rogler, Pedro A. Ruiz, Bruce Weder, Klaus Seuwen, Pedro Henrique Imenez Silva, Yu Wang, Cheryl de Valliere
Publikováno v:
Inflammatory Bowel Diseases, 28(1), 109-125. LIPPINCOTT WILLIAMS & WILKINS
BackgroundPatients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of pH-sensing receptors compared with non-IBD controls. Acidification leads to angiogenesis and extracellular matrix remodeling. We aimed to determi
Autor:
Jesus Cosin-Roger, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Katharina Baebler, Chiaki Maeyashiki, Bruce Weder, Cheryl de Valliere, Michael Scharl, Larissa Hering, Fabian Schefer, Martin Hausmann
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), a
Autor:
Chiaki Maeyashiki, Marlene Schwarzfischer, Katharina Bäbler, Gerhard Rogler, Marianne R. Spalinger, Kirstin Atrott, Philipp Busenhart, Cordelia Schuler, Cheryl de Valliere, Martin Hausmann, Michael Scharl, Silvia Lang, Pedro Ruiz-Castro
Publikováno v:
Inflamm Intest Dis
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD). Several recent studies reported a link between IBD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca9bf684319eef4aba66a0e5e60343c
https://europepmc.org/articles/PMC8527911/
https://europepmc.org/articles/PMC8527911/
Autor:
Isabelle Frey-Wagner, Jelena Kühn-Georgijevic, Susan Bengs, Shola M Richards, Irina Tcymbarevich, Benjamin Misselwitz, Cheryl de Valliere, Silvia Lang, Jesus Cosin-Roger, Carsten A. Wagner, Sven Gruber, Kirstin Atrott, Gerhard Rogler, Pedro A. Ruiz, Katharina Baebler, Marianne R. Spalinger, Carla Bettoni, Klaus Seuwen, Giancarlo Russo, Michael Scharl
Publikováno v:
Journal of Crohn's and Colitis. 13:245-258
Background Tissue inflammation in inflammatory bowel diseases [IBD] is associated with local acidification. Genetic variants in the pH-sensing G protein-coupled receptor 65, also known as T cell death-associated gene 8 [TDAG8], have been implicated i
Autor:
Simona Simmen, Jesus Cosin-Roger, Cheryl de Valliere, Katharina Spanaus, Katharina Baebler, Chiaki Maeyashiki, Nikolaos Maliachovas, Jonas Zeitz, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Stephan R. Vavricka, Bruce Weder, Max Maane, Martin Hausmann, Michael Scharl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)
Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecti
Autor:
Max Maane, Isabelle Frey-Wagner, Stephan R. Vavricka, Bruce Weder, Martin Hausmann, Simona Simmen, Cheryl de Valliere, Silvia Lang, Katherina Baebler, Jonas Zeitz, Roland H. Wenger, Gerhard Rogler, Pedro A. Ruiz, Sarah Rogler, Partick Spielmann, Jesus Cosin-Roger, Kirstin Atrott
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Inflamm Intest Dis
Inflamm Intest Dis
Introduction: Intestinal fibrosis, characterized by excessive deposition of extracellular matrix proteins, is a common and severe clinical complication of inflammatory bowel disease (IBD). However, the mechanisms underlying fibrosis remain elusive, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd44de8628c56e83213f0597d47da192
https://www.karger.com/Article/FullText/513061
https://www.karger.com/Article/FullText/513061
Autor:
Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0283060 (2024)
Acidosis is one of the hallmarks of demyelinating central nervous system (CNS) lesions in multiple sclerosis (MS). The response to acidic pH is primarily mediated by a family of G protein-coupled proton-sensing receptors: OGR1, GPR4 and TDAG8. These
Externí odkaz:
https://doaj.org/article/ec819292dc9944ad9a7599de537dd7fa
Autor:
Isabelle Frey-Wagner, Gerhard Rogler, Roland H. Wenger, Pedro A. Ruiz, Kirstin Atrott, Simona Simmen, Jesus Cosin-Roger, Marianne R. Spalinger, Patrick Spielmann, Jonas Zeitz, Stephan R. Vavricka, Cheryl de Valliere, Hassan Melhem, Martin Hausmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation du
Autor:
Gerhard Rogler, Pedro A. Ruiz, Cheryl de Valliere, Jonas Zeitz, Jyrki J. Eloranta, Hassan Melhem, Irina Tcymbarevich, Kirstin Atrott, Benjamin Misselwitz, Gerd A. Kullak-Ublick, Michael Fried, Klaus Seuwen, Carsten A. Wagner, Mehdi Madanchi, Jesus Cosin-Roger, Simona Simmen, Stephan R. Vavricka
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 6, Pp 796-810 (2016)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a re
Autor:
Wouter T. van Haaften, Pedro Henrique Imenez Silva, Benjamin Misselwitz, Tina Raselli, Senta Hutter, Gerard Dijkstra, Achim Weber, Gerhard Rogler, Martin Hausmann, Isabelle Frey-Wagner, Pedro A. Ruiz, C. Meier, Céline Mamie, Cheryl de Valliere, Katharina Baebler, Anouk Hünerwadel, Bruce Weder, Carsten A. Wagner, Neel Herfarth
Publikováno v:
Journal of Crohn's and Colitis, 12(11), 1348-1358. Oxford University Press
Background and Aims: pH-sensing ovarian cancer G-protein coupled receptor-1 [OGR1/GPR68] is regulated by key inflammatory cytokines. Patients suffering from inflammatory bowel diseases [IBDs] express increased mucosal levels of OGR1 compared with non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b708e888804b5e5ca92c516373d8aeee
https://research.rug.nl/en/publications/56626491-a621-4adb-905d-1d153414b1c0
https://research.rug.nl/en/publications/56626491-a621-4adb-905d-1d153414b1c0