Výsledky vyhledávání - "Cheryl T. Hewkin"

New Synthesis of Substituted 2-Carboxyindole Derivatives: Versatile Introduction of a Carbamoylethynyl Moiety at the C-3 Position

Autor: Cheryl T. Hewkin, Alfredo Cugola, Paola Gastaldi, Romano Di Fabio, Nadia Conti, Fabrizio Micheli, Anna M. Quaglia

Publikováno v: Archiv der Pharmazie. 332:55-58

A novel series of 3-carbamoylethynyl-2-carboxyindoles, antagonists acting at the strychnine-insensitive glycine binding site associated with the NMDA receptor, has been synthesised. This new versatile approach involves the introduction of a 2-chloroe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38135c7ac174c992de0797c33fd59f70
https://doi.org/10.1002/(sici)1521-4184(19993)332:2<55::aid-ardp55>3.0.co

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Substituted Indole-2-carboxylates as in Vivo Potent Antagonists Acting as the Strychnine-Insensitive Glycine Binding Site

Autor: Luciana Rossi, A. Feriani, Fabrizio Micheli, Anna M. Quaglia, Anna-Maria Capelli, David G. Trist, Paola Gastaldi, Angelo Reggiani, Alfredo Cugola, E. Ratti, Daniele Donati, Angelo Pecunioso, Manolo Mugnaini, Cheryl T. Hewkin, R. Di Fabio, Nadia Conti, Giovanna Tedesco, Andrea Missio, Giovanni Gaviraghi

Publikováno v: Journal of Medicinal Chemistry. 40:841-850

A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions induced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27560a1551c483698a602ee0a0e903ed
https://doi.org/10.1021/jm960644a

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ChemInform Abstract: Diastereoselective Synthesis of Cyclopropanes with Multiple Sulfur Substitution. X-Ray Molecular Structures of Phenylsulfonyl-Substituted Cyclopropanes

Autor: Cheryl T. Hewkin, Peter L. Bailey, Richard F. W. Jackson, William Clegg

Publikováno v: ChemInform. 24

Reaction of 1-phenylsulfonyl-1-phenylthioalkenes 3 with lithiated phenyl phenylthiomethyl sulfone 4 gave 1-phenylsulfonyl-1, 2-bis(phenylthio)cyclopropanes 5 as single diastereoisomers in good yield. The relative stereochemistry of the cyclopropane 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::212b4f668b11206b4a5c0ac35edcad47
https://doi.org/10.1002/chin.199326099

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ChemInform Abstract: Computer-Assisted Design of Chiral Boron Enolates: The Role of Ate Complexes in Determining Aldol Stereoselectivity

Autor: Anna Bernardi, Achim Schlapbach, Angiolina Comotti, Ian Paterson, Cheryl T. Hewkin, Jonathan M. Goodman, Cesare Gennari

Publikováno v: ChemInform. 25

Transition-state modelling for the aldol reaction of chiral Z and E enol borinates ( 1 and 2 , Scheme 1 ) bearing mixed ligands (L 1 = Ipc, L 2 = 9 ) predicted higher enantioselectivities than those calculated and experimentally tested with C 2 symme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68e377b020eb52a0d3aae3e51ea6ab5b
https://doi.org/10.1002/chin.199421054

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ChemInform Abstract: New Synthesis of Substituted 2-Carboxyindole Derivatives: Versatile Introduction of a Carbamoylethynyl Moiety at the C-3-Position

Autor: Paola Gastaldi, Anna M. Quaglia, Nadia Conti, Alfredo Cugola, Romano Di Fabio, Fabrizio Micheli, Cheryl T. Hewkin

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::918945d576cd5165255b46449160a9c5
https://doi.org/10.1002/chin.199926117

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A new method for the synthesis of α-bromoacyl silanes via ring-opening of 2-phenylsulphonyl-2-trimethylsilyloxiranes

Autor: Cheryl T. Hewkin, Richard F. W. Jackson

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :3103-3111

2-Phenylsulphonyl-2-trimethylsilyloxiranes 2 are efficiently prepared by treatment of 2-phenylsulphonyloxiranes 3 with butyllithium in the presence of chlorotrimethylsilane at low temperatures. Reaction of 3-alkyl-2-phenylsulphonyl-2-trimethylsilylox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34361284452dd04a19b4f24f6dffaf1b
https://doi.org/10.1039/p19910003103

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Preparation and ring-opening reactions of 2-phenylsulphonyl-2-trimethylsilyl-oxiranes

Autor: Richard F. W. Jackson, Cheryl T. Hewkin

Publikováno v: Tetrahedron Letters. 31:1877-1880

Reaction of 2-phenylsulphonyl oxiranes (1) with butyllithium in the presence of chlorotrimethylsilane gave 2-phenylsulphonyl-2-trimethylsilyl oxiranes (2) , which on treatment with MgBr 2 Et 2 O gave 2-bromoacylsilanes (3) and either bromovinyl sulph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9545ecf6d453c36126f11da92c10e131
https://doi.org/10.1016/s0040-4039(00)98809-9

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2,6-Diphenyl-3-vinylpyridine

Autor: Richard F. W. Jackson, William Clegg, Cheryl T. Hewkin

Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 51:525-527

In the structure of C 19 H 15 N, steric interactions force all three substituents (one vinyl and two phenyl groups) out of coplanarity with the central pyridine ring. Individual torsion angles around the relevant bonds are in the ranges 33.2 (3)36.1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e5e22c98fe4b7def154d44312f3c6e9
https://doi.org/10.1107/s0108270194010814

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Computer-assisted design of chiral boron enolates: The role of ate complexes in determining aldol stereoselectivity

Autor: Jonathan M. Goodman, Anna Bernardi, Angiolina Comotti, Ian Paterson, Cesare Gennari, Achim Schlapbach, Cheryl T. Hewkin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47611a903e92a40198e7468a1f5c84c
http://hdl.handle.net/10281/36650

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