Výsledky vyhledávání - "Cheryl Stahle"

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

Autor: Gilbert H. Smith, Robert Callahan, Daniel Gallahan, Glenn Merlino, E Chu, Chamelli Jhappan, Cheryl Stahle

Publikováno v: Genes & Development. 6:345-355

Expression of the int-3 locus is activated in mouse mammary tumors as a consequence of insertional mutagenesis by the mouse mammary tumor virus (MMTV). Integration of the MMTV provirus into the int-3 locus promotes the transcription and translation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ccdd5050a95557134e6fa6b06190e1
https://doi.org/10.1101/gad.6.3.345

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Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

Autor: Hanan Galski, Lori J. Goldstein, Ivan Aksentijevich, Patricia V. Schoenlein, Michael M. Gottesman, Cheryl Stahle, David H. Sachs, Ira Pastan, Gerald H. Mickisch

Publikováno v: Blood. 79:1087-1093

Many human cancers that are initially responsive to chemotherapy eventually fail to respond to treatment. For some drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow (BM) limit cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cc39a7828ca20908fd28f1c4a0e339a
https://doi.org/10.1182/blood.v79.4.1087.bloodjournal7941087

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Inactivation of a sperm motility gene by insertion of an epidermal growth factor receptor transgene whose product is overexpressed and compartmentalized during spermatogenesis

Autor: Cheryl Stahle, Glenn Merlino, Mark C. Willingham, Kathleen A. Mahon, Chamelli Jhappan, Robert Linton

Publikováno v: Genes & Development. 5:1395-1406

Transgenic mice were generated with a human epidermal growth factor (EGF) receptor cDNA driven by the chicken beta-actin gene promoter. One line (AE24) that exhibited a unique expression pattern in which dramatically elevated levels of EGF receptor R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec03eed8cbd07621767660418e82a59
https://doi.org/10.1101/gad.5.8.1395

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An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice

Autor: Ira Pastan, Cheryl Stahle, Glenn Merlino, Chamelli Jhappan, Michael Wolff

Publikováno v: Cellular immunology. 149(1)

To determine the range of tissues in which the human epidermal growth factor (EGF) receptor promoter is active, we created 12 independently derived lines of mice expressing a transgene consisting of human EGF receptor promoter and enhancer sequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c311a1dacda5cd9566cd2d0836d2a
https://pubmed.ncbi.nlm.nih.gov/8513514

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TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Autor: Cheryl Stahle, Chamelli Jhappan, Glenn Merlino, Richard N. Harkins, Gilbert H. Smith, Nelson Fausto

Publikováno v: Cell. 61(6)

To define the role of TGF alpha in normal tissue function and in pathogenesis, transgenic mice have been generated bearing a fusion gene consisting of the mouse metallothionein 1 promoter and a human TGF alpha cDNA. In these mice, human TGF alpha RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85537ac6cbd5b7eb8e5a7f4baed3755
https://pubmed.ncbi.nlm.nih.gov/2350785

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