Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cheryl Spence"'
Autor:
Robert von Bernuth, Michael A. Cotta, Susan M. Hengemuehle, Terence R. Whitehead, Cheryl Spence, M. T. Yokoyama
Publikováno v:
Journal of Environmental Quality. 45:1838-1846
Emission of odorous and toxic gases from stored livestock manure is well documented and poses a serious health risk to farmers and livestock. Hydrogen sulfide emissions have been sharply rising with increasingly intensive livestock production and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a097064bd8861ce6cdb4fb727e43b9df
https://doi.org/10.2134/jeq2016.06.0219
https://doi.org/10.2134/jeq2016.06.0219
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a633bbb07d24cb3c7b6963f9c8c2b89d
https://doi.org/10.1016/j.bmcl.2014.04.049
https://doi.org/10.1016/j.bmcl.2014.04.049
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaa5f9f792871c6acf6b9f50fdaa356
https://doi.org/10.1021/jm3008689
https://doi.org/10.1021/jm3008689
Autor:
Brian J. Kerr, Terence R. Whitehead, T. E. Weber, Michael A. Cotta, Cherie J. Ziemer, Cheryl Spence
Publikováno v:
Journal of Animal Science. 89:426-437
Two experiments investigated the impact of dietary inorganic S on growth performance, intestinal inflammation, fecal composition, and the presence of sulfate-reducing bacteria (SRB). In Exp. 1, individually housed pigs (n = 42; 13.8 kg) were fed diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e19109be376f63e869018f9addf8981
https://doi.org/10.2527/jas.2010-3228
https://doi.org/10.2527/jas.2010-3228
Autor:
Ramakanth Sarabu, Jianping Lou, Achyutharao Sidduri, David J Moore, Jagdish Kumar Racha, Joseph Grimsby, Wendy Lea Corbett, Cheryl Spence, Robert Francis Kester, Linda Marcus, Mark T. Dvorozniak, Joseph F. Grippo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5673-5676
The phenylacetamide 1 represents the archtypical glucokinase activator (GKA) in which only the R -isomer is active. In order to probe whether the chiral center could be replaced, we prepared a series of olefins 2 and show in the present work that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72e2baff0f8f67baf0032bba968bb91
https://doi.org/10.1016/j.bmcl.2010.08.029
https://doi.org/10.1016/j.bmcl.2010.08.029
Autor:
Joseph Grimsby, Robert Francis Kester, Aruna Railkar, Cheryl Spence, Nancy-Ellen Haynes, Kevin Richard Guertin, Paige Erin Mahaney, Lida Qi, John Tengi, Wendy Lea Corbett, Fred Thomas Bizzarro, Mark T. Dvorozniak, George W. Holland, Joseph F. Grippo, Franz M. Matschinsky, Darryl W. Hilliard, Ramakanth Sarabu
Publikováno v:
Journal of Medicinal Chemistry. 53:3618-3625
Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is illustrated in patients with GK mutations. In this publication, identification of the hit molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b04c9f71b7dc5668c9b393926609d9
https://doi.org/10.1021/jm100039a
https://doi.org/10.1021/jm100039a
Publikováno v:
Journal of Applied Microbiology. 105:2143-2152
Aims: To develop and evaluate primer sets targeted to the dissimilatory sulfite reductase gene (dsrA) for use in quantitative real-time PCR detection of sulfate-reducing bacteria (SRB) in stored swine manure. Methods and Results: Degenerate primer se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a94b4cc445e85794a740a901da02bb
https://doi.org/10.1111/j.1365-2672.2008.03900.x
https://doi.org/10.1111/j.1365-2672.2008.03900.x
Publikováno v:
Anaerobe. 14:172-180
Hydrogen sulfide, produced by sulfate-reducing bacteria (SRB), is one of the most potent malodors emitted from anaerobic swine waste storage systems. However, little is known about the prevalence and diversity of SRB in those systems. The goals of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a178d53e8858cb9c18fc3c88afc202
https://doi.org/10.1016/j.anaerobe.2008.03.003
https://doi.org/10.1016/j.anaerobe.2008.03.003
Autor:
Keith Mansfield, James Trevaskis, Cheryl Spence, Jean-Rene Galarneau, Xiaosong Wang, Chandrassegar Saravanan, William A. Chutkow
Publikováno v:
The FASEB Journal. 29
Studies in the past have shown that bile ductular hyperplasia correlates with the degree of hepatic fibrosis and that myofibroblasts are a major component of cholangiocellular carcinoma (CCA). Howe...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f14adfed57c0d49bccd27e94afaeab8
https://doi.org/10.1096/fasebj.29.1_supplement.45.6
https://doi.org/10.1096/fasebj.29.1_supplement.45.6
Publikováno v:
Journal of Bacteriology. 188:4663-4672
The opportunistic pathogen Bacteroides fragilis is a commensal organism in the large intestine, where it utilizes both dietary and host-derived polysaccharides as a source of carbon and energy. In this study, a four-gene operon required for starch ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc025e31f68d378c0c357d4609144fbe
https://doi.org/10.1128/jb.00125-06
https://doi.org/10.1128/jb.00125-06