Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cheryl Schmidt"'
Autor:
Jonathan T. Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W. Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Ramalho, Raquel Mary Rodrigues Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, Vaishnavi Devarakonda, Kimberly R. Holloway, W. Victoria Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan A. Parikh, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Vera J. Suman, Kelly K. Hunt, Mark A. Watson, Katherine A. Hoadley, E. Aubrey Thompson, Xi Chen, Shyam M. Kavuri, Chad J. Creighton, Christopher A. Maher, Charles M. Perou, Svasti Haricharan, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1434-1444.e7 (2018)
Summary: RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found th
Externí odkaz:
https://doaj.org/article/b6b75cb5a81b49bf90d37ac3366f6ea7
Autor:
Matthew J. Ellis, Cynthia X. Ma, Matthew N. Bainbridge, Shyam M. Kavuri, Dean P. Edwards, Shixia Huang, Shunqiang Li, Jeremy Hoog, John A. Olson, Kelly Hunt, Vera Suman, Jonathan T. Lei, Cheryl Schmidt, Jacob Schmelz, Meenakshi Anurag, Kimberly R. Holloway, Purba Singh, Nindo Punturi, Svasti Haricharan
Supplementary Figure 1 Mismatch repair dysregulation associates with high mutation load and poor clinical outcome in patients with ER breast cancer. Supplementary Figure 2 MutL complex disruption in ER breast cancer cells induces endocrine therapy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05970a01cada46f0846e2266df7f4d18
https://doi.org/10.1158/2159-8290.22531617.v1
https://doi.org/10.1158/2159-8290.22531617.v1
Autor:
Shyam M. Kavuri, Jacob Schmelz, Vera J. Suman, Kimberly R. Holloway, Matthew N. Bainbridge, Jeremy Hoog, John A. Olson, Svasti Haricharan, Dean P. Edwards, Matthew J. Ellis, Meenakshi Anurag, Purba Singh, Nindo Punturi, Cheryl Schmidt, Shunqiang Li, Shixia Huang, Cynthia X. Ma, Jonathan T. Lei, Kelly K. Hunt
Publikováno v:
Cancer Discovery. 7:1168-1183
Significant endocrine therapy–resistant tumor proliferation is present in ≥20% of estrogen receptor–positive (ER+) primary breast cancers and is associated with disease recurrence and death. Here, we uncover a link between intrinsic endocrine t
Autor:
Matthew N. Bainbridge, John A. Olson, Kimberly R. Holloway, Meenakshi Anurag, Purba Singh, Jacob Schmelz, Svasti Haricharan, Vera J. Suman, K. K. Hunt, MJ Ellis, Cheryl Schmidt
Publikováno v:
Cancer Research. 77:PD2-06
Estrogen receptor positive (ER+) breast cancer accounts for the majority of breast cancers diagnosed worldwide but fortunately, outcomes are markedly improved by pharmacological interventions that interrupt ER function. Unfortunately, suppression of
Publikováno v:
Imprint. 63(4)
Autor:
Rodrigo Franco Gonçalves, Xian Chen, Christopher A. Maher, Sherri R. Davies, Katherine A. Hoadley, Jeremy Hoog, Anna Rogers, MJ Ellis, Jing Zhang, Chad J. Creighton, Jonathan T. Lei, Robert J. Crowder, W-C Lai, Oliver A. Hampton, Y Kosaka, K. K. Hunt, DW Chan, Vera J. Suman, CM Perou, Cheryl Schmidt, Mark F. Watson, Ryoichi Matsunuma, Michael D. Iglesia, A. Thompson, Ethan Tobias, Svasti Haricharan, Xiaoping He, Jieya Shao, P Parikh, J Cao, Cynthia X. Ma, Susana Ramalho, Chanpheng Phommaly
Publikováno v:
Cancer Research. 77:PD2-03
Background. We previously reported an alternative ESR1 somatic gain-of-function chromosomal translocation event in a patient presenting with aggressive, endocrine therapy resistant estrogen receptor (ER) positive disease, producing an in-frame fusion
Autor:
Vera J. Suman, Katherine A. Hoadley, Xi Chen, Christopher G. Maher, Xiaping He, Shunqiang Li, Doug W. Chan, Yoshimasa Kosaka, Jeremy Hoog, Matthew J. Ellis, Raquel Mary Rodrigues Peres, Purba Singh, Nindo Punturi, Chad J. Creighton, Alex Bartram, Vaishnavi Devarakonda, Robert J. Crowder, Svasti Haricharan, Jonathan T. Lei, Shyam M. Kavuri, Mark A. Watson, Jin Zhang, Rodrigo Franco Gonçalves, Michael D. Iglesia, Jin Cao, Chanpheng Phommaly, E. Aubrey Thompson, Jieya Shao, Cheryl Schmidt, P Parikh, Cynthia X. Ma, Susana Ramalho, Ryoichi Matsunuma, Kimberly R. Holloway, Eric Jou, Kelly K. Hunt, Meenakshi Anurag, W. Victoria Lai, Sherri R. Davies, Ethan Tobias, Anna Rogers, Charles M. Perou, Oliver A. Hampton
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1434-1444.e7 (2018)
Cell reports
Cell reports
SUMMARY RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found tha
Autor:
K. K. Hunt, Svasti Haricharan, Dean P. Edwards, Kimberly R. Holloway, Purba Singh, Nindo Punturi, Shyam M. Kavuri, Shuhong Li, Shixia Huang, John A. Olson, Meenakshi Anurag, Cynthia X. Ma, Vera J. Suman, Matthew N. Bainbridge, Jacob Schmelz, Jonathan T. Lei, Jeremy Hoog, MJ Ellis, Cheryl Schmidt
Publikováno v:
Cancer Research. 78:P4-04
Estrogen receptor positive (ER+) breast cancer is treated with endocrine therapy but intrinsic resistance occurs in ˜1/3 of patients and acquired resistance in ˜1/5 of the remainder. While many resistance mechanisms have been explored, clinical tri
Autor:
Mark F. Watson, Ethan Tobias, MJ Ellis, Sherri R. Davies, K. K. Hunt, Shyam M. Kavuri, Rodrigo Franco Gonçalves, Anna Rogers, Katherine A. Hoadley, A. Thompson, Jin Cao, Oliver A. Hampton, Jonathan T. Lei, Ryoichi Matsunuma, Jing Zhang, Meenakshi Anurag, DW Chan, Vera J. Suman, Robert J. Crowder, Svasti Haricharan, Christopher A. Maher, Chad J. Creighton, Cheryl Schmidt, W-C Lai, Yoshimasa Kosaka, Jeremy Hoog, Michael D. Iglesia, Puneet Singh, Jieya Shao, Chanpheng Phommaly, Raquel Mary Rodrigues-Peres, P Parikh, Cynthia X. Ma, Susana Ramalho, CM Perou
Publikováno v:
Cancer Research. 78:PD8-03
Background. Dysregulation of the estrogen receptor gene (ESR1) is an established mechanism of inducing endocrine therapy resistance. We previously discovered a chromosomal translocation event generating an estrogen receptor gene fused in-frame to C-t
Autor:
Kelly K. Hunt, Jeremy Hoog, Cheryl Schmidt, Vera J. Suman, Shyam M. Kavuri, Shunqiang Li, Dean P. Edwards, Kimberly R. Holloway, Svasti Haricharan, Shixia Huang, Cynthia X. Ma, Matthew J. Ellis, Meenakshi Anurag, Purba Singh, Jacob Schmelz, John A. Olson, Matthew N. Bainbridge
Publikováno v:
Cancer Research. 77:489-489
Estrogen receptor positive (ER+) breast cancer is treated with endocrine therapy but intrinsic resistance occurs in ~1/3 of patients and acquired resistance in ~1/5 of the remainder. While many resistance mechanisms have been explored, therapeutic st