Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Cheryl Santos"'
Autor:
Arunee Dechaphunkul, Monlika Phukaoloun, Kanet Kanjanapradit, Kathryn Graham, Sunita Ghosh, Cheryl Santos, John R. Mackey
Publikováno v:
International Journal of Breast Cancer, Vol 2012 (2012)
Introduction. Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both
Externí odkaz:
https://doaj.org/article/f6714795f7544557a2646b76b62b7e84
Autor:
Scott North, Raymond Lai, John R. Mackey, Carol E. Cass, Cheryl Santos, Sunita Ghosh, Faraj El-Gehani
Publikováno v:
Journal of Urology. 191:35-39
In pancreatic cancer, deoxycytidine kinase and the human equilibrative nucleoside transporter 1 have been validated as predictive markers for benefit from gemcitabine therapy. Gemcitabine is used with cisplatin or carboplatin as neoadjuvant chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf278e058237cd36cb60548106bd73de
https://doi.org/10.1016/j.juro.2013.07.006
https://doi.org/10.1016/j.juro.2013.07.006
Autor:
Cheryl Santos, Sunita Ghosh, Kanet Kanjanapradit, Kathryn Graham, Arunee Dechaphunkul, Monlika Phukaoloun, John R. Mackey
Publikováno v:
Cancer Research. 71:P4-09
Background: Despite advances of systemic treatment in breast cancer guided by hormonal status and HER2 amplification, new prognostic and predictive factors are still warranted to optimize treatments among these patients. Tissue Inhibitor of Metallopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3267caa9e272e4c55ac340f45ed731ee
https://doi.org/10.1158/0008-5472.sabcs11-p4-09-26
https://doi.org/10.1158/0008-5472.sabcs11-p4-09-26
Autor:
Xuejun Sun, Jennifer Dufour, Liang Li, Cheryl Santos, Lidan Tao, Carol E. Cass, John R. Mackey, Vijaya L. Damaraju, Nan Li, Sambasivarao Damaraju, David S. Wishart, Nan Zhang
Publikováno v:
Analytical Biochemistry. 396:69-75
Sucrose density gradient-enriched membrane preparations and membrane fraction enrichment through affinity purification techniques are commonly used in proteomic analysis. However, published proteomic profiles characterized by the above methods show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c013069495393390126bc968288aa7
https://doi.org/10.1016/j.ab.2009.08.019
https://doi.org/10.1016/j.ab.2009.08.019
Autor:
Adam N. Elwi, Xuejun Sun, Charlene Hunter, James D. Young, Vijaya L. Damaraju, Cheryl Santos, Stephen A. Baldwin, Michael B. Sawyer, Carol E. Cass, Pat Carpenter, Gerry Barron, John R. Mackey
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F200-F211
Nucleoside transporters in kidney mediate renal reabsorption and secretion of nucleosides. Using RT-PCR, we demonstrated mRNAs encoding hENT1, hENT2, hCNT1, hCNT2, and hCNT3 in both cortex and medulla. Immunoblotting with crude membrane preparations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339669a10cd09f3452e8c609eb4cf4a2
https://doi.org/10.1152/ajprenal.00007.2007
https://doi.org/10.1152/ajprenal.00007.2007
Autor:
Jonathan R. Dimmock, Umashankar Das, Gordon A. Zello, S. G. R. Gunda, Sarvesh C. Vashishtha, Kurt H. Nienaber, Theresa M. Allen, Cheryl Santos, J. P. Stables
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 19:303-312
A series of 1-(3-aryl-2-propenoyl)-4-oxopiperidines (1) as well as some related semicarbazones (2) and thiosemicarbazones (3) were prepared in order to determine whether the relative locations of aryl rings and amidic groups would lead to novel antic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f966dd258f288afd4a3db5d92396f
https://doi.org/10.1080/14756360409162442
https://doi.org/10.1080/14756360409162442
Autor:
John R. Mackey, Carlos M. Galmarini, Emeline Cros, Christian Périgaud, Cheryl Santos, Charles Dumontet, Lars Petter Jordheim, Gilles Gosselin, Marilyn L Clarke
Publikováno v:
International Journal of Cancer. 107:149-154
Adequate intracellular concentrations of ara-CMP, the monophosphorylated derivative of ara-C, are essential for its cytotoxicity. The critical step for ara-CMP formation is intracellular phosphorylation of ara-C by deoxycytidine kinase (dCK). A commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274c4fb544e8c786fb2d83876ba0c079
https://doi.org/10.1002/ijc.11339
https://doi.org/10.1002/ijc.11339
Autor:
Jan Balzarini, Amitabh Jha, James P. Stables, Theresa M. Allen, Elias K. Manavathu, Jonathan R. Dimmock, Ponniah Selvakumar, Cheryl Santos, Anuraag Shrivastav, Rajendra K. Sharma, Gordon A. Zello, E. De Clercq
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 18:325-332
A series of novel 3,5-bis(phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones 3 have been synthesized which displayed potent cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine P388 and L1210 leukemic cells. In contrast, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a60bc2888151e326df4b75c943a30aa
https://doi.org/10.1080/1475636031000121938
https://doi.org/10.1080/1475636031000121938
Autor:
J. Wilson Quail, Cheryl Santos, Jeremy S. Lee, Jared S Prisciak, Jan Balzarini, Theresa M. Allen, Maniyan P Padmanilyam, Erik De Clercq, Heinz-Bernhard Kraatz, Elias K. Manavathu, Eliud O. Oloo, Gordon A. Zello, Jonathan R. Dimmock, James P. Stables, Arten Cherkasov
Publikováno v:
European Journal of Medicinal Chemistry. 37:813-824
A number of 1,3-arylidene-2-tetralones 1, 2 and 4 were synthesised and demonstrated cytotoxic activity towards murine P388 and L1210 cells as well as human Molt 4/C8 and CEM T-lymphocytes. In general, the related 1-arylidene-2-tetralones 3 possessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a0923a8393b96141dd56854dd8d917
https://doi.org/10.1016/s0223-5234(02)01402-2
https://doi.org/10.1016/s0223-5234(02)01402-2
Publikováno v:
Analytical Chemistry. 74:2573-2577
The human equilibrative nucleoside transporter 1 protein (hENT1) is a major mediator of cellular entry of nucleosides and anticancer nucleoside drugs; its assay is important in understanding and diagnosing chemotherapy resistance. Here we present a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9068b54b1fa8270d548928d25796654
https://doi.org/10.1021/ac025559r
https://doi.org/10.1021/ac025559r