Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cheryl Paes"'
Autor:
Anu Thomas, Chidananda Sulli, Edgar Davidson, Eli Berdougo, Morganne Phillips, Bridget A. Puffer, Cheryl Paes, Benjamin J. Doranz, Joseph B. Rucker
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Although bitter taste receptors (TAS2Rs) are important for human health, little is known of the determinants of ligand specificity. TAS2Rs such as TAS2R16 help define gustatory perception and dietary preferences that ultimately influence hum
Externí odkaz:
https://doaj.org/article/12f45ce1b6b94a4e81f404c14a6ac2b5
Autor:
Tracy M. Handel, Melanie P. Wescott, Irina Kufareva, Jason R. Goodman, Bridget A. Puffer, Cheryl Paes, Yana Thaker, Eli Berdougo, Benjamin J. Doranz, Joseph Rucker
Publikováno v:
Proceedings of the National Academy of Sciences. 113:9928-9933
The atomic-level mechanisms by which G protein-coupled receptors (GPCRs) transmit extracellular ligand binding events through their transmembrane helices to activate intracellular G proteins remain unclear. Using a comprehensive library of mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985bcf54c2372a63a27787f2ed51356b
https://doi.org/10.1073/pnas.1601278113
https://doi.org/10.1073/pnas.1601278113
Autor:
Benjamin J. Doranz, Cheryl Paes, Bridget A. Puffer, Chidananda Sulli, Anu Thomas, Eli Berdougo, Joseph Rucker, Edgar Davidson, Morganne Phillips
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Although bitter taste receptors (TAS2Rs) are important for human health, little is known of the determinants of ligand specificity. TAS2Rs such as TAS2R16 help define gustatory perception and dietary preferences that ultimately influence human health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157828e0595080d802ce591e5380e932
https://doi.org/10.1038/s41598-017-07256-y
https://doi.org/10.1038/s41598-017-07256-y
Autor:
Kimberly-Anne Mattia, Elizabeth A. Christian, Edgar Davidson, Benjamin J. Doranz, Jennifer M. Pfaff, Cheryl Paes, Kristen M. Kahle, Adam D. Miller, Bridget A. Puffer
Publikováno v:
Proceedings of the National Academy of Sciences. 110:18662-18667
A number of structures have been solved for the Envelope (E) protein from dengue virus and closely related flaviviruses, providing detailed pictures of the conformational states of the protein at different stages of infectivity. However, the key func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eebc9b8defa7a5c55c29d52400cc35c
https://doi.org/10.1073/pnas.1310962110
https://doi.org/10.1073/pnas.1310962110
Autor:
Riley Payne, Xiaoxiao Xiang, Justin Schilling, Sharon H. Willis, Chidananda Sulli, Cheryl Paes, Antony G. Wanless, Soma S. R. Banik, Benjamin J. Doranz, Allan Moser, Joseph Rucker
Publikováno v:
Journal of Virology. 87:10679-10686
The influenza virus M2 protein is a well-validated yet underexploited proton-selective ion channel essential for influenza virus infectivity. Because M2 is a toxic viral ion channel, existing M2 inhibitors have been discovered through live virus inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d256e36a7bd19cc9c1d86a19fbe178
https://doi.org/10.1128/jvi.01190-13
https://doi.org/10.1128/jvi.01190-13
Autor:
Nathan M. Liss, Adam Miller, Graham Simmons, Kimberly-Anne Mattia, David F. Tucker, Kristen M. Kahle, Rachel H. Fong, Soma S. R. Banik, Marcus O. Muench, Joseph Rucker, Surabhi Srinivasan, Suganya Selvarajah, Alain Michault, Cheryl Paes, Kai Lu, Benjamin J. Doranz, Manu Mabila, Trevor Barnes
Publikováno v:
Journal of Virology
Chikungunya virus (CHIKV) is a reemerging alphavirus that causes a debilitating arthritic disease and infects millions of people and for which no specific treatment is available. Like many alphaviruses, the structural targets on CHIKV that elicit a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12349b79ea3a44e933d12055c22ceeed
https://europepmc.org/articles/PMC4249124/
https://europepmc.org/articles/PMC4249124/
Autor:
Kimberly-Anne Mattia, Moniquetta Hall, Sharon H. Willis, Manu Mabila, Rohan Keshwara, Joseph R. Couto, Joseph Rucker, Riley Payne, Cheryl Paes, Benjamin J. Doranz, Christine Rettew
Publikováno v:
Cancer Research. 75:656-656
Integral membrane proteins are important drug targets and monoclonal antibodies (MAbs) directed against them are highly sought for therapeutic purposes. However, the complex structure of membrane protein targets makes the discovery of these MAbs espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73004bfd390f46124a207eb330b09130
https://doi.org/10.1158/1538-7445.am2015-656
https://doi.org/10.1158/1538-7445.am2015-656
Autor:
Yana Thaker, Anu Thomas, Joseph Rucker, Joseph R. Couto, Jason R. Goodman, Cheryl Paes, Melanie P. Wescott, Benjamin J. Doranz
Publikováno v:
Cancer Research. 75:2441-2441
Alanine (Ala) scanning is a widely used mutagenesis approach for systematic evaluation of protein function, which for large targets can be laborious and time-consuming. We have developed a platform technology, Shotgun Mutagenesis, for rapid and compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ad3f12aa26b4d3f688360bbb73a758
https://doi.org/10.1158/1538-7445.am2015-2441
https://doi.org/10.1158/1538-7445.am2015-2441
Autor:
Meredith Murray, Benjamin J. Doranz, Jada Ingalls, Karan Kampani, Esha Kakkar, Cheryl Paes, Chidananda Sulli, Valery Kotelnikov, Tiffani A. Greene, Joseph Rucker
Publikováno v:
Journal of the American Chemical Society. 131(20)
Epitopes that define the immunodominant regions of conformationally complex integral membrane proteins have been difficult to reliably delineate. Here, a high-throughput approach termed shotgun mutagenesis was used to map the binding epitopes of five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360bc90ea1cec3b4d53b170c6819f5cc
https://pubmed.ncbi.nlm.nih.gov/19453194
https://pubmed.ncbi.nlm.nih.gov/19453194
Autor:
Kenneth R. Maksimchuk, Alexander D. Cameron, Riley Payne, Cheryl Paes, Yana Thaker, Benjamin J. Doranz, Joseph Rucker
Publikováno v:
Cancer Research. 72:4742-4742
Identifying antibody epitopes on membrane proteins can help differentiate antibody binding mechanisms, identify immunodominant structures, distinguish and classify antibodies, and identify cancer state-specific antigens, providing valuable informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e5ae0461d8ac510089bb3bafff1ada
https://doi.org/10.1158/1538-7445.am2012-4742
https://doi.org/10.1158/1538-7445.am2012-4742