Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Cheryl M. Sheppard"'
Autor:
Konrad F. Koehler, Todd J. Friends, Marlena Grynfarb, Pratik Devasthale, Arthur M. Doweyko, Bolette Husman, Howard Einspahr, Jon J. Hangeland, John S. Sack, Tamara Dejneka, Jan Ljunggren, Cheryl M. Sheppard, Karin Mellström, Johnny Sandberg, Denis E. Ryono, Mathias Färnegårdh, Johan Malm
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A set of thyromimetics having improved selectivity for TR-beta1 were prepared by replacing the 3'-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25aa20583081ad8d56e2722e4902c73c
https://pubmed.ncbi.nlm.nih.gov/15177471
https://pubmed.ncbi.nlm.nih.gov/15177471
Autor:
Zhihua Sui, Harvey M. Werblood, Jamese J. Hilliard, Barbara D. Foleno, Cheryl M. Sheppard, James P. Demers, Glenda C. Webb, Michele A. Weidner-Wells, Mark J. Macielag, Jihua Guan, Stephanie A. Fraga-Spano, John F. Barrett, Kwasi A. Ohemeng, Dennis J. Hlasta
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(14)
This SAR study has shown that the salicylanilide is the pharmacophore for inhibition of the bacterial two-component system. Hydrophobic substituents improve the potency of inhibitors in this series; however, hydrophobicity is not the sole determinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba2633618a4b2041e24d21325044ec0
https://pubmed.ncbi.nlm.nih.gov/9873460
https://pubmed.ncbi.nlm.nih.gov/9873460