Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Cheryl Lalonde"'
Publikováno v:
Shock. 9:27-32
We studied the effect of water-soluble antioxidants geared at restoring glutathione levels on oxygen consumption, cell energetics as measured by energy charge potential (ECP), glutathione levels, and mortality, in response to a 20% total body surface
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 38:175-184
The combination of burn and smoke inhalation was studied to determine if early hemodynamic and metabolic abnormalities would correspond with the degree of subsequent smoke-induced airways injury. Adult sheep (n = 45) given an 18% total body surface t
Publikováno v:
Surgery. 117:226-231
Background. Inflammation-induced disease as seen with trauma and infection can lead to increased lung oxidant activity resulting in cell membrane lipid peroxidation. Acute zymosan-induced peritonitis in rats produces lung inflammation, edema, and lip
Publikováno v:
Critical Care Medicine. 23:171-178
Objective To study the early (first 24 hrs) effect of increasing lung exposure to smoke on the hemodynamic response to a modest body burn. Design A prospective randomized study. Setting Laboratory at a university medical center. Subjects Thirty-two a
Publikováno v:
Journal of Applied Physiology. 77:2057-2064
We assessed the role of oxidant release at the airway mucosal surface on airway injury and systemic response to a severe smoke insult. Adult sheep (n = 20) were insufflated with well-characterized smoke from burning cotton toweling. A standardized do
Publikováno v:
Inflammation. 18:499-510
Acute zymosan-induced peritonitis in rats produces lung inflammation and lipid peroxidation. The effect of this process on plasma and lung tissue ascorbic acid was determined, as was the effect of infusing 150 mg/kg of ascorbic acid immediately after
Publikováno v:
SHOCK. 2:222-227
We compared the mortality rate and the lung and liver histologic injury with the degree of tissue lipid peroxidation after zymosan-induced peritonitis. Male Wistar rats were given .75 or 1 mg/g of zymosan intraperitoneally and monitored for 24 h. Tis
Publikováno v:
Shock. 1:101-107
We determined the oxidant activity in lung airways, parenchyma, and systemic tissues in response to smoke inhalation, comparing lipid peroxidation with physiologic and histologic change. Adult sheep were given a controlled amount of cooled smoke from
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 32:593-599
We determined the relationship between oxygen delivery, DO2, and oxygen consumption, VO2, in sheep after a moderate smoke inhalation injury and 15% TBSA third-degree burn compared with burn alone and controls. Comparison was made beginning three hour
Publikováno v:
Free Radical Biology and Medicine. 12:409-415
A skin burn is a common traumatic injury that results in both local tissue damage and a systematic mediater-induced response. There is evidence of both local and sysemic oxidant changes manifsted by lipid peroxidation in animal burn models and also i