Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Cheryl Lai-Lai Chiang"'
Autor:
Hajer Fritah, Michele Graciotti, Cheryl Lai-Lai Chiang, Anne-Laure Huguenin- Bergenat, Rémy Petremand, Ritaparna Ahmed, Philippe Guillaume, Julien Schmidt, Brian J. Stevenson, David Gfeller, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106288- (2023)
Summary: Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer p
Externí odkaz:
https://doaj.org/article/9001342654b947c8becf2723dc803e5f
Autor:
Chakradhar Yakkala, Julien Dagher, Christine Sempoux, Cheryl Lai-Lai Chiang, Alban Denys, Lana E. Kandalaft, Bhanu Koppolu, Rafael Duran
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The emergence of ablative therapies has revolutionized the treatment of inoperable solid tumors. Cryoablation stands out for its uniqueness of operation based on hypothermia, and for its ability to unleash the native tumor antigens, resulting in the
Externí odkaz:
https://doaj.org/article/c3ecacfdf4b54233986700323b8b7eae
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Treatment of solid tumors by ablation techniques has gained momentum in the recent years due to their technical simplicity and reduced morbidity as juxtaposed to surgery. Cryoablation is one of such techniques, known for its uniqueness to destroy the
Externí odkaz:
https://doaj.org/article/7a04c4cb3e6c48a68940dcb4839bfdda
Publikováno v:
Vaccines, Vol 3, Iss 2, Pp 344-372 (2015)
With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to
Externí odkaz:
https://doaj.org/article/3e6a39a7ce514b7793f4cc6274744a1f
Publikováno v:
Vaccines, Vol 6, Iss 4, p 79 (2018)
Although different types of therapeutic vaccines against established cancerous lesions in various indications have been developed since the 1990s, their clinical benefit is still very limited. This observed lack of effectiveness in cancer eradication
Externí odkaz:
https://doaj.org/article/028c8a16178845168da5ccefc0000caa
Autor:
Cheryl Lai-Lai Chiang, Andrea R Hagemann, Rachel Leskowitz, Rosemarie Mick, Thomas Garrabrant, Brian J Czerniecki, Lana E Kandalaft, Daniel J Powell, George Coukos
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28732 (2011)
"Day-7" myeloid DCs are commonly used in the clinic. However, there is a strong need to develop DCs faster that have the same potent immunostimulatory capacity as "Day-7" myeloid DCs and at the same time minimizing time, labor and cost of DC preparat
Externí odkaz:
https://doaj.org/article/a9c0fda4b0b64a82856d709826918e1a
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Materials, Methods, Figures and Table legends - PDF file 87K, Supplementary file giving details of supplementary materials and methods, figure legends and table legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f923f4386446ea525ea7321c30f028
https://doi.org/10.1158/1078-0432.22447283.v1
https://doi.org/10.1158/1078-0432.22447283.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Figure S2 - PDF file 84K, Phenotype of DCs following lysate-pulsing (i.e. HOCl-L, UVB-L or FTL), and activation with LPS and IFN-gamma. Unpulsed, mature (mDC) or immature DCs (iDC) served as controls. Data was presented as mean plus-min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f1ff9d27bf0b3b2d47b6ad36b462f2
https://doi.org/10.1158/1078-0432.22447292.v1
https://doi.org/10.1158/1078-0432.22447292.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Table S1 - PDF file 191K, Cytokine and chemokine productions from DCs of ovarian cancer subjects that were loaded with HOCl-oxidized autologous whole tumor lysate and matured with LPS and IFN-gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea66dfd35c14b100fa69edb35bb59b9
https://doi.org/10.1158/1078-0432.22447280.v1
https://doi.org/10.1158/1078-0432.22447280.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Purpose: Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015766474701c5816d40b182df9252fc
https://doi.org/10.1158/1078-0432.c.6521027.v1
https://doi.org/10.1158/1078-0432.c.6521027.v1