Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Cheryl L. Ackert‐Bicknell"'
Autor:
Euphy Y. Wu, Noor P. Singh, Kwangbom Choi, Mohsen Zakeri, Matthew Vincent, Gary A. Churchill, Cheryl L. Ackert-Bicknell, Rob Patro, Michael I. Love
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Detecting allelic imbalance at the isoform level requires accounting for inferential uncertainty, caused by multi-mapping of RNA-seq reads. Our proposed method, SEESAW, uses Salmon and Swish to offer analysis at various levels of resolution,
Externí odkaz:
https://doaj.org/article/9853abdefa264d67a0c9007ce9680240
Autor:
Sara E. Buckley DO, Mary C. Hamati MD, Michael A. Hewitt BA, Cheryl L. Ackert-Bicknell PhD, Michael J. Zuscik PhD, Joshua A. Metzl MD, Daniel K. Moon MD, MS, MBA, Kenneth J. Hunt MD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 7 (2022)
Category: Ankle Arthritis; Arthroscopy; Basic Sciences/Biologics; Trauma Introduction/Purpose: Post-traumatic Osteoarthritis (OA) of the ankle is a debilitating condition that impacts millions of people. However, little is known about the genetic and
Externí odkaz:
https://doaj.org/article/a5b1ce6d5bbb4fb9baa3b5d2ecf54af3
Autor:
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relatio
Externí odkaz:
https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
Autor:
Mary C. Hamati MD, Robert Maynard, Jonathan Bartolomei MS, Michael J. Zuscik PhD, Cheryl L. Ackert-Bicknell PhD, Kenneth J. Hunt MD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 7 (2022)
Category: Ankle; Ankle Arthritis; Basic Sciences/Biologics; Trauma Introduction/Purpose: Osteoarthritis (OA) of the lower limb is a debilitating, incurable, expensive and prevalent condition in people over 45. Although ankle posttraumatic OA (PTOA) h
Externí odkaz:
https://doaj.org/article/ead4f067bfd5406b96cc8da8d493df7a
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100768- (2021)
Summary: This protocol describes the application of the “omnigenic” model of the genetic architecture of complex traits to identify novel “core” genes influencing a disease-associated phenotype. Core genes are hypothesized to directly regulat
Externí odkaz:
https://doaj.org/article/56b6628c126f443fab0e810cd2f7d203
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Osteoporosis is a complex genetic disease in which the number of loci associated with the bone mineral density, a clinical risk factor for fracture, has increased at an exponential rate in the last decade. The identification of the causative variants
Externí odkaz:
https://doaj.org/article/c81ef53448dd497c904c55f70c47d28c
Autor:
Jon E. Wergedal, Cheryl L. Ackert-Bicknell, Wesley G. Beamer, Subburaman Mohan, David J. Baylink, Apurva K. Srivastava
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 8, Pp 1724-1734 (2007)
The NZB/B1NJ (NZB) mouse strain exhibits high cholesterol and HDL levels in blood compared with several other strains of mice. To study the genetic regulation of blood lipid levels, we performed a genome-wide linkage analysis in 542 chow-fed F2 femal
Externí odkaz:
https://doaj.org/article/500e8167d12f440f92d28e0bd2873d03
Publikováno v:
Current Osteoporosis Reports. 21:56-64
Publikováno v:
Current Osteoporosis Reports. 20:141-152
Autor:
Benjamin D. Kuhns, John M. Reuter, Victoria L. Hansen, Gillian L. Soles, Jennifer H. Jonason, Cheryl L. Ackert‐Bicknell, Chia‐Lung Wu, Brian D. Giordano
Publikováno v:
J Orthop Res
Femoroacetabular impingement (FAI) has a strong clinical association with the development of hip osteoarthritis (OA); however, the pathobiological mechanisms underlying the transition from focal impingement to global joint degeneration remain poorly