Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Cheryl L Stucky"'
Autor:
Alexander R Mikesell, Olena Isaeva, Francie Moehring, Katelyn E Sadler, Anthony D Menzel, Cheryl L Stucky
Publikováno v:
eLife, Vol 11 (2022)
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that
Externí odkaz:
https://doaj.org/article/ca735d72bd6c445ba329cd4bf7ffbe5e
Publikováno v:
eLife, Vol 11 (2022)
The mechanisms underlying the transition from acute to chronic pain are unclear but may involve the persistence or strengthening of pain memories acquired in part through associative learning. Contextual cues, which comprise the environment in which
Externí odkaz:
https://doaj.org/article/c75f363cd9e94cedab80ee5127831313
Publikováno v:
eLife, Vol 9 (2020)
Keratinocytes are the most abundant cell type in the epidermis, the most superficial layer of skin. Historically, epidermal-innervating sensory neurons were thought to be the exclusive detectors and transmitters of environmental stimuli. However, rec
Externí odkaz:
https://doaj.org/article/56c47eac375e4fa2a20788a2a8ccb4fc
Autor:
Francie Moehring, Ashley M Cowie, Anthony D Menzel, Andy D Weyer, Michael Grzybowski, Thiago Arzua, Aron M Geurts, Oleg Palygin, Cheryl L Stucky
Publikováno v:
eLife, Vol 7 (2018)
The first point of our body’s contact with tactile stimuli (innocuous and noxious) is the epidermis, the outermost layer of skin that is largely composed of keratinocytes. Here, we sought to define the role that keratinocytes play in touch sensatio
Externí odkaz:
https://doaj.org/article/9c7dcf58ac494d61a51cc38ddb4ec57e
Autor:
Katherine J Zappia, Sheldon R Garrison, Oleg Palygin, Andy D Weyer, Marie E Barabas, Michael W Lawlor, Alexander Staruschenko, Cheryl L Stucky
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151602 (2016)
Keratinocytes are the first cells that come into direct contact with external tactile stimuli; however, their role in touch transduction in vivo is not clear. The ion channel Transient Receptor Potential Ankyrin 1 (TRPA1) is essential for some mechan
Externí odkaz:
https://doaj.org/article/0222bd77823f49c692ddc43a9403d6c5
Autor:
Isaac M Chiu, Lee B Barrett, Erika K Williams, David E Strochlic, Seungkyu Lee, Andy D Weyer, Shan Lou, Gregory Bryman, David P Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J Cobos, Cheryl L Stucky, Qiufu Ma, Stephen D Liberles, Clifford Woolf
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/edad3ced4e2d44c28e32d49e7bf18291
Autor:
Isaac M Chiu, Lee B Barrett, Erika K Williams, David E Strochlic, Seungkyu Lee, Andy D Weyer, Shan Lou, Gregory S Bryman, David P Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J Cobos, Cheryl L Stucky, Qiufu Ma, Stephen D Liberles, Clifford J Woolf
Publikováno v:
eLife, Vol 3 (2014)
The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Her
Externí odkaz:
https://doaj.org/article/bc65ad0efece430bb716d97cb8616581
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43597 (2012)
Inflammation is a part of the body's natural response to tissue injury which initiates the healing process. Unfortunately, inflammation is frequently painful and leads to hypersensitivity to mechanical stimuli, which is difficult to treat clinically.
Externí odkaz:
https://doaj.org/article/711b2a0cbdb5447881d167dfd821cfd9
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47988 (2012)
Subpopulations of somatosensory neurons are characterized by functional properties and expression of receptor proteins and surface markers. CGRP expression and IB4-binding are commonly used to define peptidergic and non-peptidergic subpopulations. TR
Externí odkaz:
https://doaj.org/article/2bc51bece12441d78b60703815b201d2
Autor:
Daniel Vilceanu, Cheryl L Stucky
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12177 (2010)
Mechanosensitive channels serve as essential sensors for cells to interact with their environment. The identity of mechanosensitive channels that underlie somatosensory touch transduction is still a mystery. One promising mechanotransduction candidat
Externí odkaz:
https://doaj.org/article/b570a02d79804c3d9c6bb6096143fd01