Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Cheryl L Smith"'
Autor:
Andrey Poleshko, Cheryl L Smith, Son C Nguyen, Priya Sivaramakrishnan, Karen G Wong, John Isaac Murray, Melike Lakadamyali, Eric F Joyce, Rajan Jain, Jonathan A Epstein
Publikováno v:
eLife, Vol 8 (2019)
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of
Externí odkaz:
https://doaj.org/article/c643add60c814c8f8717b69f653b18d6
Publikováno v:
eLife, Vol 4 (2015)
The effects of genetic variation on gene regulation in the developing mammalian embryo remain largely unexplored. To globally quantify these effects, we crossed two divergent mouse strains and asked how genotype of the mother or of the embryo drives
Externí odkaz:
https://doaj.org/article/0a8f00e5af4243c09e8a55a23aaab102
Autor:
Andrew H Beck, Ziming Weng, Daniela M Witten, Shirley Zhu, Joseph W Foley, Phil Lacroute, Cheryl L Smith, Robert Tibshirani, Matt van de Rijn, Arend Sidow, Robert B West
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8768 (2010)
Gene expression microarrays are the most widely used technique for genome-wide expression profiling. However, microarrays do not perform well on formalin fixed paraffin embedded tissue (FFPET). Consequently, microarrays cannot be effectively utilized
Externí odkaz:
https://doaj.org/article/4b188761151c4748a7d11746f8c8cdb2
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery. However, the mech
Externí odkaz:
https://doaj.org/article/e83eab2fedac4361950be030c40f3261
Publikováno v:
Circulation Research. 131
The nuclear periphery, including the nuclear lamina, serves as an important three-dimensional organizer of the genome. Together, with a subset of tethering proteins, nuclear lamina serves as a platform to anchor transcriptionally silent heterochromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264a1af2a4b3c4c72792eca33cf9910a
https://doi.org/10.1161/res.131.suppl_1.p3096
https://doi.org/10.1161/res.131.suppl_1.p3096
Publikováno v:
Nucleic Acids Research
Nuclear architecture influences gene regulation and cell identity by controlling the three-dimensional organization of genes and their distal regulatory sequences, which may be far apart in linear space. The genome is functionally and spatially segre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a88919ebba7d5b7bd27dac51951e10
http://europepmc.org/articles/PMC8216274
http://europepmc.org/articles/PMC8216274
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery. However, the mechanisms b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959ee4d48e5817b5f61c0a489349a2a7
https://doi.org/10.1101/2022.05.17.492278
https://doi.org/10.1101/2022.05.17.492278
Autor:
Jonathan A. Epstein, Kelvin See, Jun Li, Andrey Poleshko, Anna A. Kiseleva, Cheryl L. Smith, Feiyan Liu
Publikováno v:
Dev Biol
Spatial organization of the genome in the nucleus plays a critical role in development and regulation of transcription. A genomic region that resides at the nuclear periphery is part of the chromatin layer marked with histone H3 lysine 9 dimethyl (H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad2bdf29ff86931a3f9a74ca26ac47a
https://doi.org/10.1016/j.ydbio.2020.07.010
https://doi.org/10.1016/j.ydbio.2020.07.010
Autor:
Nikhita A. Bolar, Li Li, Arun Padmanabhan, Ashley Karnay, Haoyue Zhang, Danny S. Park, Ricardo Linares-Saldana, Andrey Poleshko, Wonho Kim, Jennifer M. Luppino, Gerd A. Blobel, Gwang Hyeon Eom, Qiaohong Wang, Eric F. Joyce, Golnaz Vahedi, Rajan Jain, Parisha P. Shah, Cheryl L. Smith, Deepak Srivastava, Son C. Nguyen, Sora Yoon, Bailey A Koch-Bojalad
Publikováno v:
Nat Genet
Nature genetics, vol 53, iss 10
Nature genetics, vol 53, iss 10
Higher-order chromatin structure regulates gene expression, and mutations in proteins mediating genome folding underlie developmental disorders known as cohesinopathies. However, the relationship between three-dimensional genome organization and embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7601ad5b545c01e68e8754c077c47a30
https://europepmc.org/articles/PMC8500624/
https://europepmc.org/articles/PMC8500624/
Publikováno v:
Science Advances
Description
Genome-wide changes in posttranslational modifications of histone H3 Lys9 guide spatial positioning of chromatin.
The nuclear architecture of rod photoreceptor cells in nocturnal mammals is unlike that of other animal cells. Mur
Genome-wide changes in posttranslational modifications of histone H3 Lys9 guide spatial positioning of chromatin.
The nuclear architecture of rod photoreceptor cells in nocturnal mammals is unlike that of other animal cells. Mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643e6c16c3dd9bb4d6eda8c083da323e
http://europepmc.org/articles/PMC8462898
http://europepmc.org/articles/PMC8462898