Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Cheryl L, Wellington"'
Autor:
Marangelie Criado-Marrero, Sakthivel Ravi, Ekta Bhaskar, Daylin Barroso, Michael A. Pizzi, Lakiesha Williams, Cheryl L. Wellington, Marcelo Febo, Jose Francisco Abisambra
Publikováno v:
NeuroImage, Vol 298, Iss , Pp 120764- (2024)
Traumatic brain injuries (TBI) present a major public health challenge, demanding an in-depth understanding of age-specific symptoms and risk factors. Aging not only significantly influences brain function and plasticity but also elevates the risk of
Externí odkaz:
https://doaj.org/article/a65f8608a5d5467cb97194cbac21e60d
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). Humans have a peripheral lipoprotein profile where
Externí odkaz:
https://doaj.org/article/91ce294be91a4b63b8a49a31d96af572
Autor:
Melina Messing, Mypinder S. Sekhon, Michael R. Hughes, Sophie Stukas, Ryan L. Hoiland, Jennifer Cooper, Nyra Ahmed, Mark S. Hamer, Yicong Li, Samuel B. Shin, Lin Wei Tung, Cheryl L. Wellington, Don D. Sin, Kevin B. Leslie, Kelly M. McNagny
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum
Externí odkaz:
https://doaj.org/article/e664c34af33143408e6843b6957ebf8c
Autor:
Sophie Stukas, George Goshua, Angus Kinkade, Rebecca Grey, Gregory Mah, Catherine M. Biggs, Shahin Jamal, Sonny Thiara, Tim T.Y. Lau, Jolanta Piszczek, Nilu Partovi, David D Sweet, Agnes Y.Y. Lee, Cheryl L. Wellington, Mypinder S. Sekhon, Luke Y.C. Chen
Publikováno v:
The Lancet Regional Health. Americas, Vol 11, Iss , Pp 100228- (2022)
Summary: Background: Interleukin-6 inhibitors reduce mortality in severe COVID-19. British Columbia began using tocilizumab 8 mg/kg (maximum 800 mg) in January 2021 in critically ill patients with COVID-19, but due to drug shortages, decreased dosing
Externí odkaz:
https://doaj.org/article/5fe720dec2324ee885ff324e824e3cb4
Autor:
Emily B. Button, Wai Hang Cheng, Carlos Barron, Honor Cheung, Asma Bashir, Jennifer Cooper, Jasmine Gill, Sophie Stukas, David C. Baron, Jerome Robert, Elyn M. Rowe, Peter A. Cripton, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-27 (2021)
Abstract Background Glial fibrillary acidic protein (GFAP) has emerged as a promising fluid biomarker for several neurological indications including traumatic brain injury (TBI), a leading cause of death and disability worldwide. In humans, serum or
Externí odkaz:
https://doaj.org/article/f34d341eb55745efa6c3823f103e6a93
Autor:
Jerome Robert, Nicholas L. Weilinger, Li-Ping Cao, Stefano Cataldi, Emily B. Button, Sophie Stukas, Emma M. Martin, Philip Seibler, Megan Gilmour, Tara M. Caffrey, Elyn M. Rowe, Jianjia Fan, Brian MacVicar, Matthew J. Farrer, Cheryl L. Wellington
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Introduction The neurovascular unit (NVU) – the interaction between the neurons and the cerebrovasculature – is increasingly important to interrogate through human-based experimental models. Although advanced models of cerebral capillari
Externí odkaz:
https://doaj.org/article/bf6b04e51e7642eaa8ed05bcd04de018
Autor:
Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Johan Meuller, Ola Engkvist, Samantha Barichievy, Carina Raynoschek, Ryan Hicks, Marcello Maresca, Qi Wang, Dean G. Brown, Alvin Lok, Cameron Parro, Jerome Robert, Hsien-Ya Chou, Andrea M. Zuhl, Michael W. Wood, Nicholas J. Brandon, Cheryl L. Wellington
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Alzheimer’s disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed role in AD pathophysiology. A high
Externí odkaz:
https://doaj.org/article/e4c460b7e23b4bd794764f22ba342110
Autor:
Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman, Cheryl L. Wellington
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-21 (2020)
Abstract Background Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by which HDL improve cere
Externí odkaz:
https://doaj.org/article/3a3b31f2c31440f194db508534961efc
Autor:
Tiffany C. Cameron, Avineet Randhawa, Samantha M. Grist, Tanya Bennet, Jessica Hua, Luis G. Alde, Tara M. Caffrey, Cheryl L. Wellington, Karen C. Cheung
Publikováno v:
Micromachines, Vol 13, Iss 10, p 1573 (2022)
The PDMS-based microfluidic organ-on-chip platform represents an exciting paradigm that has enjoyed a rapid rise in popularity and adoption. A particularly promising element of this platform is its amenability to rapid manufacturing strategies, which
Externí odkaz:
https://doaj.org/article/3a890dbf09b44c7bbd5956a26ea1a9f1
A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
Autor:
Ebrima Gibbs, Judith M. Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L. Wellington, Ian R. Mackenzie, Steven S. Plotkin, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Advances in the understanding of Alzheimer’s disease (AD) suggest that pathogenesis is not directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO). Therapeutic antibodies targeting Aß monomers and/or p
Externí odkaz:
https://doaj.org/article/7e17d617f44d4cba8b63f9167f89ea62