Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cheryl Klein-Stevens"'
Autor:
Cheryl Klein-Stevens, Naiju Zhu, Leyte L. Winfield, Stacey A. Lomenzo, Theresa Kopajtic, Mark L. Trudell, Jonathan L. Katz, Lifen Xu, Sari Izenwasser
Publikováno v:
Journal of Medicinal Chemistry. 45:1203-1210
A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e1583a49efcf776ce66ee30eb8a2cc
https://doi.org/10.1021/jm010453u
https://doi.org/10.1021/jm010453u
Publikováno v:
Structural Chemistry. 13:491-499
The X-ray crystal structures of three ergoline derivatives have been completed and are reported herein. These include mesulergine hydrochloride (III), pergolide methanesulfonate (IV), and dihydroergocriptine hydrate (V). These molecules show dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4550e51b4dd1fcbe47cfb2500984591f
https://doi.org/10.1023/a:1020521706309
https://doi.org/10.1023/a:1020521706309
Autor:
Mark A. Scheideler, Sharon F. Cruse, Inger Søtofte, Annemarie Varming, Debasis Ghosh, Li Liang, Cheryl Klein-Stevens, A. Michael Crider, Xiaodong Song
Publikováno v:
European Journal of Medicinal Chemistry. 34:487-503
cis- and trans-2,3,3a,4,5,9b-Hexahydro-1H-benz[e]indoles were synthesized as conformationally rigid analogues of 3-phenylpyrrolidine and evaluated for dopamine (DA) D2S and D3 receptor binding affinity. The tricyclic benz[e]indole nucleus was constru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d125bc742294cc19f74bff20d081d77
https://doi.org/10.1016/s0223-5234(99)80098-1
https://doi.org/10.1016/s0223-5234(99)80098-1
Publikováno v:
Structural Chemistry. 10:91-103
A QSAR and CoMFA study including 78 cocaine analogs has been completed. These analogs have varied functional groups on the 2β and 3β positions of the tropane ring and include various stereoisomers. The CoMFA program was used to calculate the steric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7fde547e1f7fad73aa0f60e1c6afce5
https://doi.org/10.1023/a:1022029129364
https://doi.org/10.1023/a:1022029129364
Autor:
Inger Soetofte, Sharon F. Cruse, Xiaodong Song, Annemarie Varming, Debasis Ghosh, Li Liang, Cheryl Klein-Stevens, Mark A. Scheideler, A. Michael Crider
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b42b02c3fb6b3b8773c24fd04e58862
https://doi.org/10.1002/chin.199948134
https://doi.org/10.1002/chin.199948134
Autor:
Naijue Zhu, Amy L. Bradley, Sari Izenwasser, Cheryl Klein-Stevens, Mark L. Trudell, Dean Wade
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d994981d5c0917d9608b9c8120e81a2
https://doi.org/10.1002/chin.200251159
https://doi.org/10.1002/chin.200251159
Autor:
Mark L. Trudell, Sari Izenwasser, Naijue Zhu, Amy L. Bradley, Cheryl Klein-Stevens, Dean Wade
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(17)
A series of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes was synthesized and the binding affinities of the compounds were determined at the dopamine transporter. The unsubstituted analogue 7b (K(i)=98nM) was the most potent compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a52b8fdda188287dbd846eaf38d6ad6
https://pubmed.ncbi.nlm.nih.gov/12161139
https://pubmed.ncbi.nlm.nih.gov/12161139
Publikováno v:
Organic letters. 1(9)
[formula: see text] The syntheses of both exo and endo stereoisomers of 7-methyl-7-azabicyclo[2.2.1]heptan-2-ol were achieved in straightforward fashion. Alternatively, the intramolecular cyclization of syn-4-N-methylaminocyclohexane 1,2-epoxide was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba246f56100660b38125748551420b9
https://pubmed.ncbi.nlm.nih.gov/10825991
https://pubmed.ncbi.nlm.nih.gov/10825991
Publikováno v:
Journal of Chemical Crystallography; Oct2007, Vol. 37 Issue 10, p679-683, 5p