Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Cheryl Hirst"'
1
Fibroblast growth factor 2 isoforms and cardiac hypertrophy
Autor: Peter Zahradka, Peter A. Cattini, Sarah K. Jimenez, Farah Sheikh, Zhi-Sheng Jiang, Elissavet Kardami, Cheryl Hirst
Publikováno v: Cardiovascular Research. 63:458-466
Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 or CUG-initiated 21-34 kDa (hi-FGF-2) isoforms. Animal models
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35109f649aa63e9b54afd83474856f3
https://doi.org/10.1016/j.cardiores.2004.04.024
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2
The most common mutation inFKRP causing limb girdle muscular dystrophy type 2I (LGMD2I) may have occurred only once and is present in Hutterites and other populations
Autor: Mayana Zatz, Danielle Frappier, Klaus Wrogemann, Michaela Zaik, Nicole M. Roslin, Kate Bushby, Cheryl Hirst, Kenneth Morgan, Edward Nylen, Ryan E. Lamont, Cheryl R. Greenberg, T. Mary Fujiwara, Flavia de Paula, Patrick Frosk, Alysa A.P. Tennese, Volker Straub
Publikováno v: Human Mutation. 25:38-44
Limb girdle muscular dystrophy (LGMD) is common in the Hutterite population of North America. We previously identified a mutation in the TRIM32 gene in chromosome region 9q32, causing LGMD2H in approximately two-thirds of the 60 Hutterite LGMD patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b218166ea4b4dd1a901118b3956ee8be
https://doi.org/10.1002/humu.20110
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3
Chromatin compaction and cell death by high molecular weight FGF-2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria
Autor: Xitong Dang, Yan Jin, Cheryl Hirst, Xin Ma, Elissavet Kardami, Robert R. Fandrich, Claudia Grothe, Lorrie A. Kirshenbaum, Peter Claus, Peter A. Cattini
Publikováno v: Journal of cellular physiology. 213(3)
Fibroblast growth factor 2 (FGF-2) is produced as CUG-initiated, 22–34 kDa or AUG-initiated 18 kDa isoforms (hi- and lo-FGF-2, respectively), with potentially distinct functions. We report that expression of hi-FGF-2 in HEK293 cells elicited chroma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34931b7ed7154c06c5b4a9661488248d
https://pubmed.ncbi.nlm.nih.gov/17503459
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4
Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis
Autor: Farah Sheikh, Margaret E. Bock, Elissavet Kardami, Robert R. Fandrich, Peter A. Cattini, Cheryl Hirst, Yan Jin, Barbara E. Nickel, Brad W. Doble
Publikováno v: Cardiovascular research. 64(3)
Objective: : Added transforming growth factor beta (TGFβ) inhibits the proliferation of immature cardiomyocytes. We have now examined the hypothesis that suppression of endogenous TGFβ signaling will boost the proliferative response (DNA synthesis)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1df960241d3872845fb73637869a42
https://pubmed.ncbi.nlm.nih.gov/15537505
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5
High levels of CUG-initiated FGF-2 expression cause chromatin compaction, decreased cardiomyocyte mitosis, and cell death
Autor: Cheryl Hirst, Elissavet Kardami, Meenhard Herlyn, Peter A. Cattini
Publikováno v: Vascular Biochemistry ISBN: 9781461350101
Fibroblast growth factor 2 (FGF-2) is a multifunctional mitogen present in CUG-and AUG-initiated forms, referred to as ‘hi’ and `lo’ FGF-2, respectively. We have used an adenoviral vector to express the predominantly nuclear human ‘hi’ FGF-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::268a9e1a95425f43b90a308024827d16
https://doi.org/10.1007/978-1-4615-0298-2_16
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