Výsledky vyhledávání - "Cheryl H. Baker"

Data from Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression

Autor: Maen Abdelrahim, Md. Riyaz Basha, Ala Abudayyeh, James L. Abbruzzese, Stephen Safe, Cheryl H. Baker, Jimmie Colon, Santhi Konduri

Survivin is overexpressed in most human cancers, including pancreatic adenocarcinoma. Expression of survivin is regulated by specificity protein (Sp) proteins and related to resistance to radiation therapy. Tolfenamic acid induces Sp protein degradat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734e1f6ae88b84be8c264c76f8b9ffd7
https://doi.org/10.1158/1535-7163.c.6531996

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Data from Blockade of MGMT Expression by O6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

Autor: Cheryl H. Baker, Srivenugopal S. Kalkunte, Kishor K. Bhakat, Beth Isley, Jimmie Colon, Robert M. Sutphin, George C. Bobustuc, Jonathan Ticku, Santhi D. Konduri

Purpose: We sought to determine whether administration of a MGMT blocker, O6-benzyl guanine (O6BG), at an optimal biological dose alone or in combination with gemcitabine inhibits human pancreatic cancer cell growth.Experimental Design: Human pancrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45146e61a02cb7da3cee4c1a36eda07b
https://doi.org/10.1158/1078-0432.c.6517633.v1

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Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity

Autor: Judy Oestreicher, Edward M. Suh, Cheryl H. Baker, Tara P. Pitts, Qunli Xu, Priscilla L. Winder, Patricia Linley, Kaoru Mitsuhashi, Amy E. Wright, Karen TenDyke, Esther A. Guzmán

Publikováno v: International Journal of Cancer. 139:2116-2126

Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis occurs before symptoms manifest. Leiodermatolide, a polyketide macrolide with antimitotic activity isolated from a deep wate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bd32a0a21ece89d927bb4a448db235c
https://doi.org/10.1002/ijc.30253

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Synthesis and Biological Evaluation of Antimetastatic Agents Predicated upon Dihydromotuporamine C and Its Carbocyclic Derivatives

Autor: Teresa R. Johnson, Aaron Muth, Melissa S. Wason, Cheryl H. Baker, Xianlin Han, Deborah A. Altomare, Navneet Kaur, Veethika Pandey, Otto Phanstiel

Publikováno v: Journal of Medicinal Chemistry. 57:4023-4034

The motuporamines isolated from the sea sponge Xestospongia exigua are of biological interest because of their unique antimigration and antiangiogenic properties. Key bioactive features were found to be a saturated 15-membered heterocycle and a norsp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73856a7a98c08935cada35133cfdc4c
https://doi.org/10.1021/jm401906v

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Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

Autor: Sudipta Seal, Soumen Das, Jimmie Colon, Cheryl H. Baker, Melissa S. Wason, James Turkson, Jihe Zhao

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 9:558-569

Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff27ce3b988a28c15461baf8d21cd49
https://doi.org/10.1016/j.nano.2012.10.010

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Harnessing nanoparticles to improve toxicity after head and neck radiation

Autor: Rafael Madero-Visbal, Beatrice Alvarado, Jimmie Colon, Melissa S. Wason, Beth Isley, Cheryl H. Baker, R. Manon, Chris M. Lee, Sudipta Seal, Soumen Das

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 8:1223-1231

This article reports the evaluation of cerium oxide (CeO 2 ) nanoparticles' ability to decrease xerostomia and radiation-induced dermatitis in mice after head and neck radiation. Mice were irradiated using an IC160 x-ray system. Two cohorts were incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fdd918f9ec25bb73fa2c34da417459
https://doi.org/10.1016/j.nano.2011.12.011

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Phosphate ester hydrolysis of biologically relevant molecules by cerium oxide nanoparticles

Autor: Suresh Babu, Jimmie Colon, Melissa Hirsch Kuchma, Artëm E. Masunov, Justin M. Summy, Andrew Teblum, Cheryl H. Baker, Beatrice Alvarado, Sudipta Seal, Christopher Bligh Komanski

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 6:738-744

In an effort to characterize the interaction of cerium oxide nanoparticles (CNPs) in biological systems, we explored the reactivity of CNPs with the phosphate ester bonds of p-nitrophenylphosphate (pNPP), ATP, o-phospho-l-tyrosine, and DNA. The activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2fb80a309d46a46229ef2217dc0319
https://doi.org/10.1016/j.nano.2010.05.004

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Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice

Autor: Cheryl H. Baker, David Sheikh-Hamad, Beatrice Alvarado, Riyaz Basha, Maen Abdelrahim, Luis J. Herrera, Ala Abudayyeh, Stephen Safe, Rafael Madero-Visbal, Jimmie Colon, Santhi D. Konduri

Publikováno v: Investigational New Drugs. 29:41-51

The nonsteroidal anti-inflammatory drug (NSAID), tolfenamic acid (TA) is emerging as a new anti-cancer agent. TA induces the degradation of specific Specificity protein (Sp) transcription factors, Sp1, Sp3 and Sp4 which are associated with tumor grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da812c1dc164e900f6e3f4d17dbb46f3
https://doi.org/10.1007/s10637-009-9331-8

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Blockade of MGMT Expression by O6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

Autor: Srivenugopal S. Kalkunte, Cheryl H. Baker, Robert M. Sutphin, Jonathan Ticku, George C. Bobustuc, Jimmie Colon, Santhi D. Konduri, Beth Isley, Kishor K. Bhakat

Publikováno v: Clinical Cancer Research. 15:6087-6095

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9240d998e9a89b67cd4e2246b44c6d7e
https://doi.org/10.1158/1078-0432.ccr-09-0887

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