Zobrazeno 1 - 10
of 523
pro vyhledávání: '"Cheryl H Arrowsmith"'
Autor:
Xiao-Chuan Cai, Tuo Zhang, Eui-jun Kim, Ming Jiang, Ke Wang, Junyi Wang, Shi Chen, Nawei Zhang, Hong Wu, Fengling Li, Carlo C dela Seña, Hong Zeng, Victor Vivcharuk, Xiang Niu, Weihong Zheng, Jonghan P Lee, Yuling Chen, Dalia Barsyte, Magda Szewczyk, Taraneh Hajian, Glorymar Ibáñez, Aiping Dong, Ludmila Dombrovski, Zhenyu Zhang, Haiteng Deng, Jinrong Min, Cheryl H Arrowsmith, Linas Mazutis, Lei Shi, Masoud Vedadi, Peter J Brown, Jenny Xiang, Li-Xuan Qin, Wei Xu, Minkui Luo
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/529e0f4d945f41b89585de51965cfd50
Autor:
Mélanie Criqui, Aditi Qamra, Tsz Wai Chu, Monika Sharma, Julissa Tsao, Danielle A Henry, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Neil Winegarden, Mathieu Lupien, Lea Harrington
Publikováno v:
eLife, Vol 9 (2020)
The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylati
Externí odkaz:
https://doaj.org/article/2ac1413380124dc5835c1b12f2df0bbc
Autor:
Xiao-Chuan Cai, Tuo Zhang, Eui-jun Kim, Ming Jiang, Ke Wang, Junyi Wang, Shi Chen, Nawei Zhang, Hong Wu, Fengling Li, Carlo C dela Seña, Hong Zeng, Victor Vivcharuk, Xiang Niu, Weihong Zheng, Jonghan P Lee, Yuling Chen, Dalia Barsyte, Magda Szewczyk, Taraneh Hajian, Glorymar Ibáñez, Aiping Dong, Ludmila Dombrovski, Zhenyu Zhang, Haiteng Deng, Jinrong Min, Cheryl H Arrowsmith, Linas Mazutis, Lei Shi, Masoud Vedadi, Peter J Brown, Jenny Xiang, Li-Xuan Qin, Wei Xu, Minkui Luo
Publikováno v:
eLife, Vol 8 (2019)
CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with
Externí odkaz:
https://doaj.org/article/e2cc04f7ee7c46688f502928eba49e93
Autor:
Shengrui Feng, Sajid A. Marhon, Dustin J. Sokolowski, Alister D’Costa, Fraser Soares, Parinaz Mehdipour, Charles Ishak, Helen Loo Yau, Ilias Ettayebi, Parasvi S. Patel, Raymond Chen, Jiming Liu, Philip C. Zuzarte, King Ching Ho, Ben Ho, Shiyao Ning, Annie Huang, Cheryl H. Arrowsmith, Michael D. Wilson, Jared T. Simpson, Daniel D. De Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH
Externí odkaz:
https://doaj.org/article/0d1e7015e2c14b349eee324205203761
Autor:
Joseph Walton, Angel S. N. Ng, Karen Arevalo, Anthony Apostoli, Jalna Meens, Christina Karamboulas, Jonathan St-Germain, Panagiotis Prinos, Julia Dmytryshyn, Eric Chen, Cheryl H. Arrowsmith, Brian Raught, Laurie Ailles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to epigenetic manipulation. A l
Externí odkaz:
https://doaj.org/article/c3c9ce48e93f480088b52266f80ffb05
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay
Publikováno v:
eLife, Vol 6 (2017)
Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors s
Externí odkaz:
https://doaj.org/article/65b653e5554744cebb68c1ea76c5bd1d
Autor:
Julie M Grondin, Da Duan, Alyssa C Kirlin, Kento T Abe, Seth Chitayat, Holly L Spencer, Craig Spencer, Alisha Campigotto, Scott Houliston, Cheryl H Arrowsmith, John S Allingham, Alisdair B Boraston, Steven P Smith
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171606 (2017)
Clostridium perfringens is a commensal member of the human gut microbiome and an opportunistic pathogen whose genome encodes a suite of putative large, multi-modular carbohydrate-active enzymes that appears to play a role in the interaction of the ba
Externí odkaz:
https://doaj.org/article/15b16005f3af4b5d974ed4a06e218ffd
Autor:
Lena Münzker, Serah W. Kimani, Milan M. Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M. Zak, Anthony K. L. Leung, Jonathan M. Elkins, Dirk Kessler, Cheryl H. Arrowsmith, Levon Halabelian, Jark Böttcher
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The WWE domain is a relatively under-researched domain found in twelve human proteins and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif. Six of these WWE domain-containing proteins also contain domains wit
Externí odkaz:
https://doaj.org/article/d563b7d731e84d30bedff15301871bf2
Autor:
Joseph S Harrison, Evan M Cornett, Dennis Goldfarb, Paul A DaRosa, Zimeng M Li, Feng Yan, Bradley M Dickson, Angela H Guo, Daniel V Cantu, Lilia Kaustov, Peter J Brown, Cheryl H Arrowsmith, Dorothy A Erie, Michael B Major, Rachel E Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D Strahl, Scott B Rothbart
Publikováno v:
eLife, Vol 5 (2016)
The epigenetic inheritance of DNA methylation requires UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly replicated DNA through ubiquitylation of histone H3. UHRF1 binds DNA with selectivity towards hemi
Externí odkaz:
https://doaj.org/article/a0c4f588bf4d4946bb43d1fe3709ba4c